Free radicals are highly reactive molecules or chemical species that are competent enough of independent existence. Free radicals can cause “oxidative stress,” a process that can trigger cell damage. Oxidative stress is thought to play a role in a variety of diseases including cancer, cardiovascular diseases, diabetes, Alzheimer’s disease, Parkinson’s disease. Increasing the antioxidant intake can prevent diseases and lower the health problems. Generation of highly Reactive Oxygen Species (ROS) is an integral feature of normal cellular function like mitochondrial respiratory chain, phagocytosis, arachidonic acid metabolism, ovulation, and fertilisation. Antioxidants combat oxidative stress by working to neutralise excess free radicals and stopping them from starting the chain reactions that contribute to various diseases and early aging. Different types of natural antioxidants are present in fruit and vegetables; they have synergistic interactions that are important due to their activity and regenerative potential.
Chandani T. Desai,
Gaurav S. Shah,
Antioxidants: Fascinating and Favourable Biomolecules for Humans, Science Innovation.
Vol. 3, No. 6,
2015, pp. 113-116.
Andorn AC, Britton RS, Bacon BR. (1990) Evidence that lipid peroxidation and total iron are increased in Alzheimer’s brain. Neurobiol Aging11: 316.
Bauer V, Bauer F. (1999) Reactive oxygen species as mediators of tissue protection and injury. Gen PhysiolBiophys18: 7 - 14.
Becker, E. M.; Nissen, L. R.; Skibsted, L. H. (2004) Antioxidant evaluation protocols: Food quality or health effects. Eur. Food Res. Technol219: 561 - 571.
Block G, Patterson B, Subar A. (1992) Fruits, vegetables and cancer prevention: A review of epidemiological evidence. NutrCancer18: 1 - 29.
Brown, N. S., & Bicknell, R. (2001). Hypoxia and oxidative stress in breast cancer: Oxidative stress: its effects on the growth, metastatic potential and response to therapyof breast cancer. Breast Cancer Research, 3: 323 - 327, 0167 - 6806, Print, 1573 - 7217, (Online).
Contestabile A. (2001) Oxidative stresses in neurodegeneration: mechanisms and therapeutic perspectives. Curr Top MedChem1 (6): 553 - 68.
Copp RP, Wisniewski T, Hentatin F et al. (1999) Localisation of alphatocopherol transfer protein in the brains of patients with ataxia with vitamin E deficiency and other oxidative stress related neurodegenerative disorders. Brain Res822 (1 - 2): 80 - 7.
Duan M, Chen Z, Qiu J, et al. (2006) Low - dose, long - term caroverine administrationattenuates impulse noise - induced hearing loss in the rat. ActaOtolaryngologica.This paper investigates the use of low - dose, long - term caroverine as a novel drug to protect against NIHL. 126: 1140–1147.
Duan M, Agerman K, Ernfors, Canlon B. (2009) Complementary roles of neurotrophin 3 and an N - methyl - D - aspartate antagonist in the protection of noise and aminoglycoside - induced ototoxicity. Pro Natl AcadSci U S A97: 7597–7602.
Ebenezer, O., Farombi, A., &Olatunde. (2011). Antioxidative and chemopreventiveproperties of Vernoniaamygdalina and Garcinia biflavonoid. International Juornal ofEnvironment Researc and Public Health, 8: 2533 - 2555, 1661 - 7827, Print, 1660 - 4601, (Online).
Fuchs - Tarlovsky, V., Bejarano - Rosales, M., Gutierrez - Salmeán, G., Casillas, MA, López - Fukumura, H, Sato, M, Kezuka, K, Sato, I, Feng, X, Okumura, S, Fujita, T, Yokoyama, U, Eguchi, H, Ishikawa, Y, & Saito, T. (2012). Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells.The Jornal of Physiological Sciences, 1880 - 6546, (Print), 1880 - 6562, Online, 62: 251 - 257.
Fukumura, H, Sato, M, Kezuka, K, Sato, I, Feng, X, Okumura, S, Fujita, T, Yokoyama, U, Eguchi, H, Ishikawa, Y, & Saito, T. (2012). Effect of ascorbic acid on reactive oxygenspecies production in chemotherapy and hyperthermia in prostate cancer cells. The Jornal of Physiological Sciences, 1880 - 6546, (Print), 1880 - 6562, Online, 62: 251 - 257.
Gupta, V, & Sharma, M. (2012). Phytochemical Analysis and Evaluation of AntioxidantActivities of Methanolic Extracts of Maytenusemarginata. 1536 - 2310, (Print), 1557 - 8100, Online, 16 (5): 257 - 262.
Gutteridge, J. M. C.; Halliwell, B. (2010). Antioxidants: Molecules, medicines and myths. Biochem. Biophys. Res. Commun., 393: 561 - 564.
Halliwell B, Gutteridge JMC. (1989) In free radicals in Biology and Medicine, 2nd Ed, Oxford University Press, Oxford, UK.
Halliwell, B. (2007). Oxidative stress and cancer: have we moved forward? BiochemicalJournal, 401: 1 - 11, 0264 - 6021, Print, 1470 - 8728, (Online).
Halliwell B. (1994) Free radicals, antioxidants and human disease: curiosity, cause or consequences? Lancet, 344: 721 - 4.
Head E, Liu J, Hagen TM, et al (2002). Oxidative damage increases with age in a canine model of human brain aging. JNeurochem82: 375–381.
Hu, M. L. (2011). Dietary Polyphenols as Antioxidants and Anticancer Agents: MoreQuestions than Answers. Chang Gung Medical Journal, 2072 - 0939, 34: 449 - 459.
Jacob RA (1995). The integrated antioxidant system. Nutr Res 15 (5): 755 - 66.
Jayaprakash, V., & Marshall, J. R. (2011). Selenium and other antioxidants for chemoprevention of gastrointestinal cancers. Best Practtice& Research Clinical Gastroenterology, 25: 507 - 518, 1521 - 6918.
Khan, N., Afaq, F., Saleem, M., Ahmad, N., & Mukhtar, H. (2006). Targeting multiplesignaling pathways by green tea polyphenol (−) - epigallocatechin - 3 - gallate. Cancer Research, 66: 2500 - 2505, 0008 - 5472, Print, 1538 - 7445, Online.
Krishnaiah, D.; Sarbatly, R.; Nithyanandam, R. (2010) A review of the antioxidant potential of medicinal plant species. Food Bioprod. Process., doi: 10.1016/j.fbp.2010.04.008.
Le Prell CG, Yamashita D, Minami SB, et al. (2007). Mechanisms of noise - induced hearing loss indicate multiple methods of prevention. Hear Res. This is an excellent comprehensive review of the mechanism of NIHL and antioxidant effects on NIHL226: 22–43.
Le T, Keithley EM. (2007). Effects of antioxidants on the aging inner ear. This paper illustrates the importance of an antioxidant rich diet on the auditory system. Hear Res226: 194–202.
Li, Q., Zhao, H. F., Zhang, Z. F., Liu, Z. G., Pei, X. R., Wang, J. B., Cai, M. Y., & Li, Y. (2009). Long - term administration of green tea catechins prevents age - related spatiallearning and memory decline in C57BL/6 J mice by regulating hippocampal cyclicAMP - response element binding protein signaling cascade. Neuroscience, 159: 1208 - 1215, 0306–4522.
Martinez, M. E. (2005). Primary prevention of colorectal cancer: Lifestyle, nutrition, exercise. Recent Results in Cancer Research, 166: 177 - 211, 0080 - 0015.
Mazdak, H., & Zia, H. (2012). Vitamin e reduces superficial bladder cancer recurrence: a randomized controlled trial. International Journal of Preventive Medicine, 3: 110 - 115.
Mitchell JJ, Paiva M, Heaton MB. (1999). Vitamin E and beta - carotene protect against ethanol combined with ischaemia in an embryonic rat hippocampal culture model of fetal alcohol syndrome. Neurosci Lett 263 (2 - 3): 189 - 92.
Middleton, Jr. E.; Kandaswami, C.; Theoharides, T.C. (2008). The effects of plant flavonoids on mammalian cells: Implication for inflammations, heart disease and cancer. Pharmacol. Rev. 52: 673 - 751.
Noda, N., &Wakasugi, H. (2000). Cancer and oxidative stress. Journal of the JapanMedical Association, 124 (11): 1571 - 1574, 1356 - 8650.
Podsędek, A. (2007) Natural antioxidants and antioxidant activity of Brassica vegetables: A review. LWT - Food Sci. Technol., 40: 1 - 11.
Ratnam, D. V.; Ankola, D. D.; Bhardwaj, V.; Sahana, D. K.; Kumar, M.N.V.R. (2006).Role of antioxidants in prophylaxis and therapy: A pharmeumaceutical perspective. J. Control Release.113: 189 - 207.
Shen, L.; Hong - Fang, J.; Hong - Yu, Z. (2007) How to understand the dichotomy of antioxidants. Biochem. Biophys. Res. Commun. 362: 543 - 545.
Sies H, Stahl W, Sundquist AR, (1992)Antioxidant function of vitamins, vitamins E and C, beta - carotene, and other carotenoids, Annals of the New York Academy of Science, 669: 7 - 20.
Slaga, T. J. (1995). Inhibition of the induction of cancer by antioxidants. Advances inExperimental Medicine and Biology, 369: 167 - 174, 0065 - 2598.
Spoendlin H. (1971) Primary structural changes in the organ of corti after acoustic overstimulation. ActaOtolaryngol (Stockh) 71: 166–176.
Szpetnar, M., Matras, P., Kiełczykowsk, a, M., Horecka, A., Bartoszewska, L., Pasternak, K., &Rudzki, S. (2012). Antioxidants in patients receiving total parenteral nutritionafter gastrointestinal cancer surgery. Cell Biochemistry and Funciont, 30: 211 - 216, 1099 - 0844, Online.
Thapa, D., & Ghosh, R. (2012). Antioxidants for prostate cancer chemoprevention: Challenges and opportunities. Biochemical Pharmacology, 83: 1319 - 1330, 0006 - 2952.
Uttara, B., Singh, A. V., Zamboni, P., & Mahajan, R. T. (2009). Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream AntioxidantTherapeutic Options. Current Neuropharmacology. 7: 65 - 74, 0157 - 0159 X.
Yu ZF, Bruce - Keller AJ, Goodman Y, Mattson, MP. (1998) Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischaemic brain injury invivo. J Neurosci Res. 53 (5): 613 - 25.