The Role of Attractive Van der Waals Forces in the Interactions Between the Antiretroviral Drugs and the Blood Components
Science Innovation
Volume 4, Issue 3-1, June 2016, Pages: 10-18
Received: Sep. 13, 2015; Accepted: Sep. 13, 2015; Published: Sep. 28, 2015
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Authors
O. I. Ani, Department of Mechanical and Production Engineering, Enugu State University of Science and Technology, Agbani, Enugu State, Nigeria
S. G. Wadzani, Scientific Equipment Development Institute, Enugu, Enugu State, Nigeria
A. J. Ujam, Department of Mechanical Engineering, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
O. S. Ejiofor, Anambra State Teaching Hospital, Amaku, Awka, Anambra State, Nigeria
K. C. Mbanu, Scientific Equipment Development Institute, Enugu, Enugu State, Nigeria
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Abstract
The mechanism by which antiretroviral drugs can block the HIV virus seems weak and hence it becomes necessary to study the interaction between the HIV and the drug-coated white blood cells. The effect of the Van der Waals forces were studied to determine and understand the interaction processes in the interaction between antiretroviral drugs and the blood components in human. The method adopted involved the serial dilution of the five different antiretroviral drugs (two HAART/FDC and three single drugs) used in this study and the subsequent incubation with the blood samples collected from HIV negative persons for the absorbance measurement using a digital Ultraviolet Visible MetaSpecAE1405031Pro Spectrophotometer. The digital CD4 count machine (Cytoflowmeter) was equally used to obtain the CD4 counts of the blood samples used for this study. The variables required for the computations with the Lifshiftz formula were derived from the absorbance data. The MATLAB algorithm software tools were employed in the mathematical analysis of the very large body of data generated from the experiments. The Hamaker constants A11, A22, A33 and the combined Hamaker coefficients A131 of the various drugs interacting with the blood were obtained using the values of the dielectric constant together with the Lifshiftz equation. The absolute combined Hamaker coefficient A13Iabs (a mean of all the values of the various Hamaker coefficients) for each antiretroviral drug on uninfected blood samples were also calculated. The absolute values for the combined Hamaker coefficient, A131abs obtained for each of the five antiretroviral drugs interacting with uninfected blood samples are given thus: D1 = 0.36760×10-21Joule, D2 = 0.46337×10-21Joule, D3 = 0.53021×10-21Joule, D4 = 0.50971×10-21Joule, and D5 = 0.49599×10-21Joule. The significance of this result are the positive senses of the absolute combined Hamaker coefficient which imply net positive van der Waals forces indicating an attraction between the antiretroviral drugs and the lymphocytes. This in effect suggests effective coating or binding of the lymphocytes with the drugs. An earlier study was conducted on the Role of Repulsive Van der Waals Interactions in the Treatment of Human Immunodeficiency Virus (HIV) Infections with Antiretroviral Drugs. This study looks the other way round.
Keywords
Absorbance, Transmittance, Dielectric Constant, Hamaker Constant, Hamaker Coefficient, Lifshitz Formula, Lymphocyte, Van der Waals Forces
To cite this article
O. I. Ani, S. G. Wadzani, A. J. Ujam, O. S. Ejiofor, K. C. Mbanu, The Role of Attractive Van der Waals Forces in the Interactions Between the Antiretroviral Drugs and the Blood Components, Science Innovation. Special Issue: Innovative Researches in Science and Engineering. Vol. 4, No. 3-1, 2016, pp. 10-18. doi: 10.11648/j.si.s.2016040301.12
References
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