Levshenko T. Toxicologic and Hygienic Characteristics of p-373-2-20; p-5003-ac;p-294-2-35 Polyols and Prognosis of Their Potential Danger for Environment.
Volume 1, Issue 2, April 2013, Pages: 31-34
Received: Apr. 10, 2013;
Published: May 20, 2013
Views 3372 Downloads 122
Zhukov V., Kharkiv National Medical University, Kharkiv, Ukraine, Department of Biochemistry
Telegin V., Kharkiv National Medical University, Kharkiv, Ukraine, Department of Biochemistry
Rezunenko Y., Kharkiv National Medical University, Kharkiv, Ukraine, Department of Biochemistry
Zaytseva O., Kharkiv National Medical University, Kharkiv, Ukraine, Department of Medical and Biology Physics
Knigavko V., Kharkiv National Medical University, Kharkiv, Ukraine, Department of Medical and Biology Physics
Grankina S., Kharkiv National Medical University, Kharkiv, Ukraine, Department of Medical and Biology Physics
Levshenko T., Kharkiv National Medical University, Kharkiv, Ukraine, Department of Medical and Biology Physics
Follow on us
Studied the toxic effects polyoxipropylenpolyols in acute and subacute experiments on warm-blooded animals. It is established that they are pertained to the IV hazard class; have polytropic general toxic effect; on the level of toxic doses they influence on the generative function and the genetic apparatus; inhibit and disrupt the interaction between the cellular and humoral immunity.Experiments were performed on adult Wistar white rats, white mouses, guinea pigs, hybrid mouse lines BALB / C, (SBAc57BL) F1, CBA / Lac, and rabbits of the chinchilla race [4-6]. The objects of the investigation were polyoxipropylenthriols with molecular masses 5000M (P-5003-AC), and 370M (P-373-2-20), and polyoxipropylated amine with molecular mass 290M (P-294-2-35). Polyoxipropylenpolyols P-5003-AC, P-373-2-20 and P-294-2-35 in doses of 1/10 and 1/100 DL50 have a toxic effect on the generatic function and the genetic apparatus, and in doses 1/10, 1/100 and 1/1000 DL50 inhibit and disrupt the cooperative interaction of cellular and humoral immunity. In all cases, the dose of 1/10000 DL50 was inoperative, it is equal to 3.23; 3.62 and 1.48 mg / kg of animal weight, respectively, for P-373-2-20, P-5003-AC and P-294-2- 35.
Xenobiotics, General Toxic Effect, the Specific Types of Biological Effects
To cite this article
Levshenko T. Toxicologic and Hygienic Characteristics of p-373-2-20; p-5003-ac;p-294-2-35 Polyols and Prognosis of Their Potential Danger for Environment., Science Research.
Vol. 1, No. 2,
2013, pp. 31-34.
Chih Hao Chang, Ching Ting Tsao, Ken Yu Chang, Szu Hsien Chen, Jin Lin Han, Kuo Huang Hsieh. Effects of types and length of soft-segments on the physical properties and blood compatibility of polyurethanes. Journal
Bourdès A, Rudder S, East AK, Poole PS. Mining the Sinorhizobium meliloti Transportome to Develop FRET Biosensors for Sugars, Dicarboxylates and Cyclic Polyols. PLoS One. 2012; 7(9): e43578. doi: 10.1371/journal.pone.0043578. Epub 2012 Sep 24.
Young JP, Crossman L, Johnston A, Thomson N, Ghazoui Z, et al.(2006) The genome of Rhizobium leguminosarum has recognizable core and accessory components. Genome Biol 7: R34.
Capela D, Barloy-Hubler F, Gouzy J, Bothe G, Ampe F, et al. (2001) Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021. Proc Natl Acad Sci U S A 98: 9877–9882.
Davidson AL, Chen J (2004) ATP-Binding cassette transporters in bacteria. Annu Rev Biochem 73: 241–268.
Lee S-J, Böhm A, Krug M, Boos W (2007) The ABC of binding-protein-dependent transport in Archaea. Trends Microbiol 15: 389–397.
Korponyai, C.,Kovács, R.K., Erös, G., Dikstein, S. & Kemény, L. (2011). Antiirritant properties of polyols and amino acids. Dermatitis, Vol. 22, pp.
Mulligan C, Fischer M, Thomas GH (2011) Tripartite ATP-independent periplasmic (TRAP) transporters in bacteria and archaea. FEMS Microbiol Rev 35: 68–86.
Mauchline TH, Fowler JE, East AK, Sartor AL, Zaheer R, et al. (2006) Mapping the Sinorhizobium meliloti 1021 solute-binding protein-dependent transportome. Proc Natl Acad Sci U S A 103: 17933–17938.
Fehr M, Okumoto S, Deuschle K, Lager I, Looger LL, et al. (2005) Development and use of fluorescent nanosensors for metabolite imaging in living cells. Biochem Soc Trans 33: 287–290.