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A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women

Received: 06 November 2014    Accepted: 17 November 2014    Published: 24 November 2014
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Abstract

Background: Pre-eclampsia is a hypertensive disorder in pregnancy, that has adverse maternal and perinatal outcomes. Abnormal serum lipid levels have been implicated in the pathogenesis of pre-eclampsia, this can give rise to increased oxidative stress and then subsequently, endothelial dysfunction. Methods: This study was a comparative cross-sectional study that involved fifty pregnant women that had pre-eclampsia and another fifty healthy pregnant women. Cases and controls were matched for Age in years, Parity, Gestational age in weeks and Body mass index in Kg/M2. Fasting venous blood samples were obtained and analyzed for serum levels of total cholesterol, triglycerides, low-density lipoproteins (LDL), and high-density lipoproteins (HDL) using enzymatic colorimetric method aided by Cobass C111 Autoanalyser machine. The Data was analyzed using Epi-info version 3.5.4, CDC, Atlanta, USA and P <0.05 was considered significant. Results: Mean age of the case and control groups were 28.86 + 4.50 Years and 29.9 + 4.95 Years respectively (P = 0.59). Statistical analysis revealed no significant difference in terms of total Cholesterol (P = 0.98) and low density lipoprotein (P = 0.92). However, mean triglycerides (1.95 + 0.89 mmol/L versus 1.02 + 0.51 mmoI/L) was significantly higher in women with pre-eclampsia compared to the control (P= 0.0004) and a significant reduction in high density lipoprotein (0.79± 0.30 mmol/L versus 1.74 + 0.45 mmol/L) in the case group (P = 0.0005). Conclusion: In this study, Pre-eclampsia is associated with elevated serum triglycerides and reduced high density lipoprotein. These findings may serve as screening markers for preeclampsia.

DOI 10.11648/j.sr.20140206.11
Published in Science Research (Volume 2, Issue 6, December 2014)
Page(s) 150-154
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Pre-Eclampsia, Serum Lipids, Total Cholesterol, Triglycerides, High Density Lipoprotein, Low Density Lipoprotein

References
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[2] Jason JS, Waugh, Maria CS. Hypertensive disorder. In: Edmonds DK(ed) Dewhurst’s Textbook of Obstetrics and gynaecology, 8th edition. Wiley- Blackwell Publishing 2007; 101-2.
[3] Abudu O.O, Afolabi B.B. Pregnancy induced hypertension, Pre-eclampsia and Chronic hypertension. In: Akin Agboola (Ed), Textbook of Obstetrics and Gynaecology for Medical Students. 2nd edition; Heinemann Educational Books. 2006:350-51.
[4] Vanderjagt DJ, El-Nafaty AU, Melah GS et.al High density lipoprotein and homocysteine levels correlate inversely in preeclamptics women in Northern Nigeria. Acta Obstet Gynaecol Scand J 2004; 83: 536-42.
[5] NAF Islam, MAR Chodwury, GM Kibria et.al Study of serum lipid profile in pre-eclampsia and Eclampsia. Faridpur Med coll J 2010;5:56-9.
[6] Siddiqui IA. Maternal seum lipids in women with Preeclampsia. Ann Med Health Sci Res 2014;4:638-41.
[7] Young BC, Levine RJ, Karumanchi SA. Pathogenesis of Preeclampsia. Annu Rev Pathol 2010,5:173-92.
[8] Enquobahrie DA, Williams MA, Buttler CL, et.al Maternal plasma lipid concentration in early pregnancy and risk of preeclampsia. Am J Hypertens 2008; 17: 74-81.
[9] Belo L, Caslake M, Gaffney D et.al Changes in LDL size and HDL concentration in normal and preeclamptics pregnancies. Atherosclerosis 2002; 162:425-32.
[10] Brown MA, Lindheimer MD, de Sweit M. The classification and diagnosis of the hypertensive disorder of pregnancy. Statement from the international society for the study of hypertension in pregnancy (ISSHP) Hypertens Pregnancy 2001; 20:9-14.
[11] Zinat B, Iffat A, Shah ABS. Association between lipid profile and Preeclampsia. Ibrahim card Med J 2011; 1:41-44.
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[14] Lima VJ, Andrade CR et.al Serum Lipid levels in Pregnancies complicated by Preeclampsia. Sao Paulo Med J 2011; 129:73-76.
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[17] Abubakar A. Mabrouk M. Girei AB et.al Lipid profiles and Platelet counts of pre-eclamptic women in selected rural areas of Nigeria. Web Med Central Physiology.2011:2(8) WMCOO2121.
[18] Ray JG, Diamond P, Singh G, Bell CM. Brief overview of maternal triglycerides as a risk factor for pre-eclampsia. BJOG 2006; 113:379-86.
[19] Kalar MU, Kalar N, Mansoor F, Malik AR, Lessley T, Kreimer S et al. Preeclampsia and lipid levels – a case control study. International Journal of Collaborative research in internal Medicine and Public Health 2012; 4: 1738 – 45.
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Author Information
  • Department of Obstetrics and Gynaecology, Jos University Teaching Hospital, Jos, Nigeria

  • Department of Obstetrics and Gynaecology, College of Health Sciences, Bingham University, Karu, Jos Campus, Jos, Nigeria

  • Nigeria National Petroleum Corporation, Kaduna, Nigeria

  • Department of Obstetrics and Gynaecology, Jos University Teaching Hospital, Jos, Nigeria

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  • APA Style

    Yakubu Emmanuel Nyam, Ajen Stephen Anzaku, Madziga Isa Gamece, Daru Patrick Haruna. (2014). A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women. Science Research, 2(6), 150-154. https://doi.org/10.11648/j.sr.20140206.11

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    ACS Style

    Yakubu Emmanuel Nyam; Ajen Stephen Anzaku; Madziga Isa Gamece; Daru Patrick Haruna. A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women. Sci. Res. 2014, 2(6), 150-154. doi: 10.11648/j.sr.20140206.11

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    AMA Style

    Yakubu Emmanuel Nyam, Ajen Stephen Anzaku, Madziga Isa Gamece, Daru Patrick Haruna. A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women. Sci Res. 2014;2(6):150-154. doi: 10.11648/j.sr.20140206.11

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  • @article{10.11648/j.sr.20140206.11,
      author = {Yakubu Emmanuel Nyam and Ajen Stephen Anzaku and Madziga Isa Gamece and Daru Patrick Haruna},
      title = {A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women},
      journal = {Science Research},
      volume = {2},
      number = {6},
      pages = {150-154},
      doi = {10.11648/j.sr.20140206.11},
      url = {https://doi.org/10.11648/j.sr.20140206.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.sr.20140206.11},
      abstract = {Background: Pre-eclampsia is a hypertensive disorder in pregnancy, that has adverse maternal and perinatal outcomes. Abnormal serum lipid levels have been implicated in the pathogenesis of pre-eclampsia, this can give rise to increased oxidative stress and then subsequently, endothelial dysfunction.  Methods: This study was a comparative cross-sectional study that involved fifty pregnant women that had pre-eclampsia and another fifty healthy pregnant women. Cases and controls were matched for Age in years, Parity, Gestational age in weeks and Body mass index in Kg/M2. Fasting venous blood samples were obtained and analyzed for serum levels of total cholesterol, triglycerides, low-density lipoproteins (LDL), and high-density lipoproteins (HDL) using enzymatic colorimetric method aided by Cobass C111 Autoanalyser machine. The Data was analyzed using Epi-info version 3.5.4, CDC, Atlanta, USA and P <0.05 was considered significant. Results: Mean age of the case and control groups were 28.86 + 4.50 Years and 29.9 + 4.95 Years respectively (P = 0.59). Statistical analysis revealed no significant difference in terms of total Cholesterol (P = 0.98) and low density lipoprotein (P = 0.92). However, mean triglycerides (1.95 + 0.89 mmol/L versus 1.02 + 0.51 mmoI/L) was significantly higher in women with pre-eclampsia compared to the control (P= 0.0004) and a significant reduction in high density lipoprotein (0.79± 0.30 mmol/L versus 1.74 + 0.45 mmol/L) in the case group (P = 0.0005). Conclusion: In this study, Pre-eclampsia is associated with elevated serum triglycerides and reduced high density lipoprotein. These findings may serve as screening markers for preeclampsia.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - A Study of Maternal Serum Lipids in Pregnancies Complicated by Pre-Eclampsia in a Cohort of Nigerian Women
    AU  - Yakubu Emmanuel Nyam
    AU  - Ajen Stephen Anzaku
    AU  - Madziga Isa Gamece
    AU  - Daru Patrick Haruna
    Y1  - 2014/11/24
    PY  - 2014
    N1  - https://doi.org/10.11648/j.sr.20140206.11
    DO  - 10.11648/j.sr.20140206.11
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    JF  - Science Research
    JO  - Science Research
    SP  - 150
    EP  - 154
    PB  - Science Publishing Group
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    UR  - https://doi.org/10.11648/j.sr.20140206.11
    AB  - Background: Pre-eclampsia is a hypertensive disorder in pregnancy, that has adverse maternal and perinatal outcomes. Abnormal serum lipid levels have been implicated in the pathogenesis of pre-eclampsia, this can give rise to increased oxidative stress and then subsequently, endothelial dysfunction.  Methods: This study was a comparative cross-sectional study that involved fifty pregnant women that had pre-eclampsia and another fifty healthy pregnant women. Cases and controls were matched for Age in years, Parity, Gestational age in weeks and Body mass index in Kg/M2. Fasting venous blood samples were obtained and analyzed for serum levels of total cholesterol, triglycerides, low-density lipoproteins (LDL), and high-density lipoproteins (HDL) using enzymatic colorimetric method aided by Cobass C111 Autoanalyser machine. The Data was analyzed using Epi-info version 3.5.4, CDC, Atlanta, USA and P <0.05 was considered significant. Results: Mean age of the case and control groups were 28.86 + 4.50 Years and 29.9 + 4.95 Years respectively (P = 0.59). Statistical analysis revealed no significant difference in terms of total Cholesterol (P = 0.98) and low density lipoprotein (P = 0.92). However, mean triglycerides (1.95 + 0.89 mmol/L versus 1.02 + 0.51 mmoI/L) was significantly higher in women with pre-eclampsia compared to the control (P= 0.0004) and a significant reduction in high density lipoprotein (0.79± 0.30 mmol/L versus 1.74 + 0.45 mmol/L) in the case group (P = 0.0005). Conclusion: In this study, Pre-eclampsia is associated with elevated serum triglycerides and reduced high density lipoprotein. These findings may serve as screening markers for preeclampsia.
    VL  - 2
    IS  - 6
    ER  - 

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