The Comparison of Stereological Calculations of Tumour Volume with Prognostic Parameters in Breast Cancer
Science Research
Volume 4, Issue 1, February 2016, Pages: 1-6
Received: Jan. 26, 2015; Accepted: Dec. 21, 2015; Published: Jan. 11, 2016
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Authors
Aslıhan Duman, Department of Pathology, Medical Faculty of Giresun University, Giresun, Turkey
Cemal Gündoğdu, Department of Pathology, Medical Faculty of Atatürk University, Erzurum, Turkey
Elif Demirci, Department of Pathology, Medical Faculty of Atatürk University, Erzurum, Turkey
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Abstract
Purpose: In this study; we aimed to compare tumor volume with other prognostic determinants by making stereologic estimation. Material and Methods: In the mastectomy materials of 44 patients; tumor volume was calculated with the Cavaliery principle and compared with the classically known other pathologic variables. Results: There is a statistically significant correlation between histologic grade and tumor volume (p<0.05). Conclusion: It is concluded that one of the reliable parameters in the prognosis of breast cancer may be the estimation of tumor volume.
Keywords
Breast, Tumor Burden, Tumor Volume
To cite this article
Aslıhan Duman, Cemal Gündoğdu, Elif Demirci, The Comparison of Stereological Calculations of Tumour Volume with Prognostic Parameters in Breast Cancer, Science Research. Vol. 4, No. 1, 2016, pp. 1-6. doi: 10.11648/j.sr.20160401.11
References
[1]
Tokatlı Z. F, Türe M, Ömürlü K, Alas R. Ç, Uzal M. C. developing and comparing two different prognostic indexes for predicting disease-free survival of metastatic breast cancer patients. Turk J Med Sci 2011; 41(5): 769-80.
[2]
Rosai j: Breast in: Rosai and Ackerman’s Surgical Pathology. Ninth Edition London: Elsevier Inc. 2004. 1763-1839.
[3]
Tavassoli F. A., Devilee P. World Health Organization Classification of Tumours, Pathology and Genetics of Tumours of the Breast and Female Genital Organs. Lyon: IARC Press, 2003.
[4]
Rosen PP: Rosen’s Breast Pathology, Chapter 1, 12, 14, 34, Lippincott Williams and Wilkins, 2001 second ed.: 1-22, 253-256, 325-364, 627-652.
[5]
Stierer M, Rosen H, Weber R, Hanak H, Spona J, Tuchlert. Immunohistochemical and Biochemical Measurement of Estrogen and Progesterone Receptors in Primary Breast Cancer Correlation of Histopathology and Prognostic Factors, Annals of Surgery 1993 July; 218: 13-21.
[6]
Howard CV, Reed MG. Unbiased Stereology: Three dimensional measurement in microscopy. Oxford, Bios Scientific Publishers. 1998; 39-64.
[7]
Gundersen HJG. Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones in memory of William R Thomson. J Microsc. 1986; 143: 3-45.
[8]
Odacı E, Yıldırım Ş, Bahadır A, Canan S, Baş O, Bilgiç S, Kaplan S. Yeni Stereolojik Yöntemlerin Olası Hata Kaynakları Ve Çözüm Yolları. Turkiye Klinikleri J Med Sci 2004; 24(1): 78-87.
[9]
Canan S, Şahin B, Odacı E, Ünal B, Aslan H, Bilgiç S et al. Toplam Hacim, Hacim Yoğunluğu ve Hacim Oranlarının Hesaplanmasında Kullanılan Bir StereolojikYöntem: Cavalieri Prensibi. Türkiye Klinikleri Tıp bilimleri Dergisi Özel Sayısı; Stereolojide Temel Kavram ve Yöntemler 2002a; 22: 7-14.
[10]
Akbas H, Sahin B, Eroglu L, Odaci E, Bilgic S, Kaplan S et al. Estimation of Breast Prosthesis Volume by the Cavalieri Principle Using Magnetic Resonance Images. Aesthetic Plastic Surgery, 2004 September-October; 28: 275-80.
[11]
Andea AA, Bouwman D, Wallis T, Visscher DW. Correlation of tumour volume and surface area with lymph node status in patients with multifocal / multicentric breast carcinoma. 2004 Jan 1; 100: 20-7.
[12]
Ahmad Z, Khurshid A, Qureshi A, Idress R, Asghar N, Kayani N. Breast carcinoma grading, estimation of tumour size, axillary lymph node status, staging, and Nottingham prognostic index scoring on mastectomy specimens. Indian Journal of Pathology and Microbiology 2009; 52-4: 477-481.
[13]
Henson DE. Histological grading of breast cancer: Significance of grade on recurrence and mortality. Arch Pathol Lab Med 1988; 112: 1091-6.
[14]
Hopton DS, Thorogood J, Clayden AD. Histological grading of breast cancer: significance of grade on recurrence and mortality. Eur J Surg Oncol 1989; 15: 25-31.
[15]
Westenend PJ, Meurs CJC, Damhuis RAM. Tumour size and vascular invasion predict distance metastasis in stage 1 breast cancer grade distinguishes early and late metastasis. Journal of Clinical Pathology. 2005; 58: 196-201.
[16]
Tezuka K, Onoda N, Takashima T, Takagaki K, Ishikawa T, Wakasa T et al: Prognostic significance of lymphovascular invasion diagnosed by lymphatic endothelium immunostaining in breast cancer patients. Oncol Rep. 2007; 17: 997-1003.
[17]
Lee AK, Loda M, Mackarem G, Bosari S, Delellis RA, Heatley GJ et al: Lymph node negative invasive breast carcinoma or less in size (T1a, b N0 M0) clinicopathologic features and outcome. Cancer. 1997; 79: 761-771.
[18]
Siverstein MJ, Gierson ED, Waisman JR, Senofsky GM, Colburn WJ, Gamagami P. Axillary lymph node dissection for T1a breast carcinoma: is it indicated? Cancer 1994; 73: 664-667.
[19]
Altunkaynak ZB, Altunkaynak E, Unal D, Unal B. A novel application for the Cavalieri Principle: A stereological and methodological study. EAJM August 2009; 41.
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