MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping
Volume 4, Issue 6, December 2016, Pages: 405-409
Received: Dec. 6, 2016;
Published: Dec. 7, 2016
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Guo Hongyu, Biomedical Engineering, Shenyang University of Technology, Shenyang, China
Wang Yanjun, Electrical Engineering, Shenyang University of Technology, Shenyang, China
Huang Ping, Biomedical Engineering, Shenyang University of Technology, Shenyang, China
Guo Hua, Center for Biomedical Imaging Research, Tsinghua University, Beijing, China
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Purpose: MRI(Magnetic Resonance Imaging) estimates of brain iron deposition in thalassaemia patient using quantitative susceptibility mapping (QSM) and T2*-weighted methods. And to compare the two methods, if they have feasibility. Thirty-three thalassaemia patients underwent gradient echo sequence on the MR (Magnetic Resonance) scanner with whole-brain coverage to obtain the image data. Then to process the images and calculate the brain iron content using QSM (Quantitative Susceptibility Mapping) and T2*-weighted methods. Both images using QSM and T2* methods can clearly see the distribution of iron in the brain. But T2*-weighted method is less sensitivity for the detection of brain iron content, and only QSM method can quantify the iron content quickly and accurately. The tissue iron can affect the value of T2*, so T2*-weighted method can only detect the distribution of iron content. While the application of magnetic sensitive quantitative imaging can be very effective in routine non-invasive assessment of tissue components, especially iron, that is very important for the assessment of thalassemia patients.
Quantitative Susceptibility Mapping, T2*-Weighted Mapping, Magnetic Resonance Imaging, Thalassaemia, Iron Concentration
To cite this article
MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping, Science Discovery.
Vol. 4, No. 6,
2016, pp. 405-409.