A Review of Acupuncture in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
Science Discovery
Volume 6, Issue 6, December 2018, Pages: 514-520
Received: Dec. 11, 2018; Published: Dec. 12, 2018
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Authors
Dong Sha, Research Center of Mental and Neurological Disorders, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China
Li Qi, Research Center of Mental and Neurological Disorders, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China
Zhao Dongjie, Research Center of Mental and Neurological Disorders, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China
Wang Yuhua, Research Center of Mental and Neurological Disorders, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China
Xin Suicheng, Research Center of Mental and Neurological Disorders, School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China
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Abstract
Multiple sclerosis (MS) is considered an incurable inflammatory demyelinating disease of the central nervous system around the world, which damages motor, sensory and autonomic nervous function, and has the characteristics of high recurrence rate and disability rate. Treatment strategy of MS in the world is dominated by glucocorticoid and disease-modify treatments (DMTs). However, due to the shortage of drugs, expensive price, poor response to treatment, obvious side effects and so on, it gradually becomes a common goal of Chinese and Western medicine research, that we must actively explore more effective and optimal treatment strategies to control the recurrence of MS, improve neurological function disability and patient’s quality of life. Clinical reports in recent years have demonstrated that acupuncture has these characteristics of improving neurological disability, reducing fatigue, improving gait abnormality and spasm, alleviating pain, improving bladder function damage, preventing recurrence and improving whole health status in treating MS. It may become a potential ideal complementary and alternative therapy for MS. However, there are relatively few studies on the mechanism of acupuncture treatment of MS and lack of high grade evidence to support it. Undoubtedly, it’s clinical application is limited. Experimental autoimmune encephalomyelitis (EAE) model is a common animal model to study the pathophysiological mechanism of MS and evaluate the efficacy of drugs. Experimental evidences show that acupuncture intervention EAE can regulate the secretion of related immune cells and inflammatory factors, alleviate nerve injury and promote nerve rehabilitation. Therefore, in this review, we will retrospect and summarize the recent advances in acupuncture treatment of MS and EAE. So that we can understand the mechanism of acupuncture intervention in MS/EAE better, as well as provide evidence and new perspective for further clinical and scientific research in the future.
Keywords
Acupuncture, Multiple Sclerosis, Experimental Autoimmune Encephalomyelitis, Review
To cite this article
Dong Sha, Li Qi, Zhao Dongjie, Wang Yuhua, Xin Suicheng, A Review of Acupuncture in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis, Science Discovery. Vol. 6, No. 6, 2018, pp. 514-520. doi: 10.11648/j.sd.20180606.32
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