Research Progress of Exosome Non-coding RNA in Cancer
Science Discovery
Volume 7, Issue 1, February 2019, Pages: 13-17
Received: Mar. 7, 2019; Published: Mar. 8, 2019
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Authors
Jiajia Jin, School of Dentistry, Lanzhou University, Lanzhou, P. R. China
Shengrong Wu, School of Dentistry, Lanzhou University, Lanzhou, P. R. China
Xiaoyan Lu, School of Dentistry, Lanzhou University, Lanzhou, P. R. China
Zixiao Huang, School of Dentistry, Lanzhou University, Lanzhou, P. R. China
Mei’e Jia, School of Dentistry, Lanzhou University, Lanzhou, P. R. China
Xiangyi He, School of Dentistry, Lanzhou University, Lanzhou, P. R. China
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Abstract
Exosomes, secreted by both normal cells and tumor cells, are small membrane vesicle bodies that presented in saliva, blood, urine and other body fluids. The proteins, lipids, non-coding RNA and other components in exosomes functioned profoundly in cell communication and signal transduction, and tumor-derived exosomes can activate various signaling pathways and influence tumor microenvironment to participate in the tumor proliferation and migration. Non-coding RNAs play a crucial role in regulating gene expression, such as cell physiology, tumor development and tumor immunity. At present, researchs focused on exosome non-coding RNA, especially miRNA and lnRNA. In this review, we will review the tumor-derived exosome miRNA and lnRNA in tumorigenesis and development.
Keywords
Exosome, Cancer, Non-coding RNA
To cite this article
Jiajia Jin, Shengrong Wu, Xiaoyan Lu, Zixiao Huang, Mei’e Jia, Xiangyi He, Research Progress of Exosome Non-coding RNA in Cancer, Science Discovery. Vol. 7, No. 1, 2019, pp. 13-17. doi: 10.11648/j.sd.20190701.13
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