The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder

Zongling He; Fengmei Lu; Huafu Chen

doi:doi:10.11648/j.sd.20190701.17

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The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder

Zongling He, Fengmei Lu, Huafu Chen

Published in Science Discovery (Volume 7, Issue 1)

Received: 22 February 2019 Accepted: Published: 28 April 2019

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Abstract

Objective: The neuro-pathphysiological abnormalities of Major Depressive Disorder (MDD) have been reported to be distributed in emotion regulation system, involving the prefrontal cortex, limbic and subcortical nuclei[8]. Anhedonia is recognized as a hallmark of MDD. Characterizing the aberrant functional connectivity (FC) within this system and exploring the relationships between these dysconnectivity and anhedonia will help us better look into the neuro-pathophysiological mechanisms underlying MDD. Methods: Sixty-three MDD and 63 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rsfMRI). The spatial pairwise clustering (SPC) analysis and network-based statistic (NBS) were used to explore the alterations in the emotion regulation system of MDD from voxel level to network level. The alterations in FC and their relationships with anhedonia symptom were explored. Result: This study suggested that the aberrant FC subnetworks within the emotion regulation system mainly involved in prefrontal-limbic system, prefrontal-striatum system and within the limbic system. In addition, the aberrant subnetworks of prefrontal cortex/anterior cingulate cortex and amygdala/hippocampus could predict the anhedonia symptom in MDD. Conclusion: These findings demonstrated that MDD showed characteristic pathological alterations of the emotion regulation system. Moreover, the abnormal FC between the prefrontal cortex/anterior cingulate cortex and the amygdala/hippocampus might be the potential neural markers of depression-related anhedonia.

Published in	Science Discovery (Volume 7, Issue 1)
DOI	10.11648/j.sd.20190701.17
Page(s)	26-31
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Major Depressive Disorder, Emotion Regulation System, Resting State, fMRI, Anhedonia

References

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[15]	V. Gabbay, B. A. Ely, Q. Li, et al. Striatum-based circuitry of adolescent depression and anhedonia [J]. J Am Acad Child Adolesc Psychiatry, 2013, 52(6): 628-41.
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APA Style

Zongling He, Fengmei Lu, Huafu Chen. (2019). The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder. Science Discovery, 7(1), 26-31. https://doi.org/10.11648/j.sd.20190701.17

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ACS Style

Zongling He; Fengmei Lu; Huafu Chen. The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder. Sci. Discov. 2019, 7(1), 26-31. doi: 10.11648/j.sd.20190701.17

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AMA Style

Zongling He, Fengmei Lu, Huafu Chen. The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder. Sci Discov. 2019;7(1):26-31. doi: 10.11648/j.sd.20190701.17

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@article{10.11648/j.sd.20190701.17,
  author = {Zongling He and Fengmei Lu and Huafu Chen},
  title = {The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder},
  journal = {Science Discovery},
  volume = {7},
  number = {1},
  pages = {26-31},
  doi = {10.11648/j.sd.20190701.17},
  url = {https://doi.org/10.11648/j.sd.20190701.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20190701.17},
  abstract = {Objective: The neuro-pathphysiological abnormalities of Major Depressive Disorder (MDD) have been reported to be distributed in emotion regulation system, involving the prefrontal cortex, limbic and subcortical nuclei[8]. Anhedonia is recognized as a hallmark of MDD. Characterizing the aberrant functional connectivity (FC) within this system and exploring the relationships between these dysconnectivity and anhedonia will help us better look into the neuro-pathophysiological mechanisms underlying MDD. Methods: Sixty-three MDD and 63 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rsfMRI). The spatial pairwise clustering (SPC) analysis and network-based statistic (NBS) were used to explore the alterations in the emotion regulation system of MDD from voxel level to network level. The alterations in FC and their relationships with anhedonia symptom were explored. Result: This study suggested that the aberrant FC subnetworks within the emotion regulation system mainly involved in prefrontal-limbic system, prefrontal-striatum system and within the limbic system. In addition, the aberrant subnetworks of prefrontal cortex/anterior cingulate cortex and amygdala/hippocampus could predict the anhedonia symptom in MDD. Conclusion: These findings demonstrated that MDD showed characteristic pathological alterations of the emotion regulation system. Moreover, the abnormal FC between the prefrontal cortex/anterior cingulate cortex and the amygdala/hippocampus might be the potential neural markers of depression-related anhedonia.},
 year = {2019}
}

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TY  - JOUR
T1  - The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder
AU  - Zongling He
AU  - Fengmei Lu
AU  - Huafu Chen
Y1  - 2019/04/28
PY  - 2019
N1  - https://doi.org/10.11648/j.sd.20190701.17
DO  - 10.11648/j.sd.20190701.17
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 26
EP  - 31
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20190701.17
AB  - Objective: The neuro-pathphysiological abnormalities of Major Depressive Disorder (MDD) have been reported to be distributed in emotion regulation system, involving the prefrontal cortex, limbic and subcortical nuclei[8]. Anhedonia is recognized as a hallmark of MDD. Characterizing the aberrant functional connectivity (FC) within this system and exploring the relationships between these dysconnectivity and anhedonia will help us better look into the neuro-pathophysiological mechanisms underlying MDD. Methods: Sixty-three MDD and 63 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rsfMRI). The spatial pairwise clustering (SPC) analysis and network-based statistic (NBS) were used to explore the alterations in the emotion regulation system of MDD from voxel level to network level. The alterations in FC and their relationships with anhedonia symptom were explored. Result: This study suggested that the aberrant FC subnetworks within the emotion regulation system mainly involved in prefrontal-limbic system, prefrontal-striatum system and within the limbic system. In addition, the aberrant subnetworks of prefrontal cortex/anterior cingulate cortex and amygdala/hippocampus could predict the anhedonia symptom in MDD. Conclusion: These findings demonstrated that MDD showed characteristic pathological alterations of the emotion regulation system. Moreover, the abnormal FC between the prefrontal cortex/anterior cingulate cortex and the amygdala/hippocampus might be the potential neural markers of depression-related anhedonia.
VL  - 7
IS  - 1
ER  -

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Author Information

Zongling He

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China
Fengmei Lu

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China
Huafu Chen

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China

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APA Style

Zongling He, Fengmei Lu, Huafu Chen. (2019). The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder. Science Discovery, 7(1), 26-31. https://doi.org/10.11648/j.sd.20190701.17

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ACS Style

Zongling He; Fengmei Lu; Huafu Chen. The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder. Sci. Discov. 2019, 7(1), 26-31. doi: 10.11648/j.sd.20190701.17

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AMA Style

Zongling He, Fengmei Lu, Huafu Chen. The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder. Sci Discov. 2019;7(1):26-31. doi: 10.11648/j.sd.20190701.17

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@article{10.11648/j.sd.20190701.17,
  author = {Zongling He and Fengmei Lu and Huafu Chen},
  title = {The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder},
  journal = {Science Discovery},
  volume = {7},
  number = {1},
  pages = {26-31},
  doi = {10.11648/j.sd.20190701.17},
  url = {https://doi.org/10.11648/j.sd.20190701.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20190701.17},
  abstract = {Objective: The neuro-pathphysiological abnormalities of Major Depressive Disorder (MDD) have been reported to be distributed in emotion regulation system, involving the prefrontal cortex, limbic and subcortical nuclei[8]. Anhedonia is recognized as a hallmark of MDD. Characterizing the aberrant functional connectivity (FC) within this system and exploring the relationships between these dysconnectivity and anhedonia will help us better look into the neuro-pathophysiological mechanisms underlying MDD. Methods: Sixty-three MDD and 63 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rsfMRI). The spatial pairwise clustering (SPC) analysis and network-based statistic (NBS) were used to explore the alterations in the emotion regulation system of MDD from voxel level to network level. The alterations in FC and their relationships with anhedonia symptom were explored. Result: This study suggested that the aberrant FC subnetworks within the emotion regulation system mainly involved in prefrontal-limbic system, prefrontal-striatum system and within the limbic system. In addition, the aberrant subnetworks of prefrontal cortex/anterior cingulate cortex and amygdala/hippocampus could predict the anhedonia symptom in MDD. Conclusion: These findings demonstrated that MDD showed characteristic pathological alterations of the emotion regulation system. Moreover, the abnormal FC between the prefrontal cortex/anterior cingulate cortex and the amygdala/hippocampus might be the potential neural markers of depression-related anhedonia.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder
AU  - Zongling He
AU  - Fengmei Lu
AU  - Huafu Chen
Y1  - 2019/04/28
PY  - 2019
N1  - https://doi.org/10.11648/j.sd.20190701.17
DO  - 10.11648/j.sd.20190701.17
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 26
EP  - 31
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20190701.17
AB  - Objective: The neuro-pathphysiological abnormalities of Major Depressive Disorder (MDD) have been reported to be distributed in emotion regulation system, involving the prefrontal cortex, limbic and subcortical nuclei[8]. Anhedonia is recognized as a hallmark of MDD. Characterizing the aberrant functional connectivity (FC) within this system and exploring the relationships between these dysconnectivity and anhedonia will help us better look into the neuro-pathophysiological mechanisms underlying MDD. Methods: Sixty-three MDD and 63 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rsfMRI). The spatial pairwise clustering (SPC) analysis and network-based statistic (NBS) were used to explore the alterations in the emotion regulation system of MDD from voxel level to network level. The alterations in FC and their relationships with anhedonia symptom were explored. Result: This study suggested that the aberrant FC subnetworks within the emotion regulation system mainly involved in prefrontal-limbic system, prefrontal-striatum system and within the limbic system. In addition, the aberrant subnetworks of prefrontal cortex/anterior cingulate cortex and amygdala/hippocampus could predict the anhedonia symptom in MDD. Conclusion: These findings demonstrated that MDD showed characteristic pathological alterations of the emotion regulation system. Moreover, the abnormal FC between the prefrontal cortex/anterior cingulate cortex and the amygdala/hippocampus might be the potential neural markers of depression-related anhedonia.
VL  - 7
IS  - 1
ER  -

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