The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder
Science Discovery
Volume 7, Issue 1, February 2019, Pages: 26-31
Received: Feb. 22, 2019; Published: Apr. 28, 2019
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Authors
Zongling He, The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China
Fengmei Lu, The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China
Huafu Chen, The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China
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Abstract
Objective: The neuro-pathphysiological abnormalities of Major Depressive Disorder (MDD) have been reported to be distributed in emotion regulation system, involving the prefrontal cortex, limbic and subcortical nuclei[8]. Anhedonia is recognized as a hallmark of MDD. Characterizing the aberrant functional connectivity (FC) within this system and exploring the relationships between these dysconnectivity and anhedonia will help us better look into the neuro-pathophysiological mechanisms underlying MDD. Methods: Sixty-three MDD and 63 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rsfMRI). The spatial pairwise clustering (SPC) analysis and network-based statistic (NBS) were used to explore the alterations in the emotion regulation system of MDD from voxel level to network level. The alterations in FC and their relationships with anhedonia symptom were explored. Result: This study suggested that the aberrant FC subnetworks within the emotion regulation system mainly involved in prefrontal-limbic system, prefrontal-striatum system and within the limbic system. In addition, the aberrant subnetworks of prefrontal cortex/anterior cingulate cortex and amygdala/hippocampus could predict the anhedonia symptom in MDD. Conclusion: These findings demonstrated that MDD showed characteristic pathological alterations of the emotion regulation system. Moreover, the abnormal FC between the prefrontal cortex/anterior cingulate cortex and the amygdala/hippocampus might be the potential neural markers of depression-related anhedonia.
Keywords
Major Depressive Disorder, Emotion Regulation System, Resting State, fMRI, Anhedonia
To cite this article
Zongling He, Fengmei Lu, Huafu Chen, The Functional Dysconnectivity Within the Emotion Regulation System Is Associated with Anhedonia in Major Depressive Disorder, Science Discovery. Vol. 7, No. 1, 2019, pp. 26-31. doi: 10.11648/j.sd.20190701.17
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