Determination and Investigation the Nitrofurazone’s Metabolite Semicarbazide in Macrobrachium Nipponese Prawns
Science Discovery
Volume 3, Issue 2, April 2015, Pages: 10-16
Received: May 26, 2015; Accepted: Jun. 15, 2015; Published: Jul. 2, 2015
Views 3634      Downloads 91
Authors
Bing Li, Suzhou Industrial Park, Environmental Monitoring Center, Suzhou, Jiangsu, China
Hui-juan Yu, East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences (CAFS), Shanghai, China
Yun-liang Yang, Huawei Technologies Co., Ltd. Suzhou, Jiangsu, China
Article Tools
Follow on us
Abstract
Semicarbazide (SEM) is the metabolite of the illegal veterinary nitrofurazone (NFZ) in aquatic animal. However there are increasing occurrences that SEM has been found in Macrobrachium Nipponese (M. Nipponese) prawns during the routine quality controls testing for aquatic food in China since 2008. To ascertain the presence and source of SEM, prawn samples were collected from different resources (i.e., aquatic product markets, natural waters, aquaculture farms) for qualitation and quantitation, and we incubated M. Nipponese larvae in the laboratory under control for observing the SEM. SEM was detected out in all the samples analyzed, including the wild-caught samples, and it presents a regular content relationship among three parts of prawns (i.e., the shell > head > muscle). This relationship was unrelated to sample resources. In addition, a natural increase of SEM was observed after the larvae metamorphosing into postlarvae. These findings in M. Nipponense prawns can provid new evidences for further confirmation and research of the natural occurrence of SEM.
Keywords
Semicarbazide, Nitrofurazone, Macrobrachium Nipponese Prawn, Natural Occurrence, Shell
To cite this article
Bing Li, Hui-juan Yu, Yun-liang Yang, Determination and Investigation the Nitrofurazone’s Metabolite Semicarbazide in Macrobrachium Nipponese Prawns, Science Discovery. Vol. 3, No. 2, 2015, pp. 10-16. doi: 10.11648/j.sd.20150302.11
References
[1]
McCracken, R. J., Blanchflower, W. J., Rowan, C. Determination of furazolidone in porcine tissue using thermosprayliquid chromatography-mass spectrometry and a study of the pharmacokineticsand stability of its residues. Analyst, 1995, 120, 2347–2351.
[2]
Nouws, J. F. M., Laurensen, J. Postmortal. Degradation of furazolidone andfuraltadone in edible tissues of calves. Veterinary Quarterly, 1990, 12, 56–59.
[3]
Announcement by the Ministry of Agriculture No. 193, People's Republic of China.
[4]
Announcement by the Ministry of Agriculture No. 781, People's Republic of China.
[5]
European Commission, Commission Decision 2003/181/EC. Off. J. Eur. Communities.
[6]
Veterinary Drug Residue Monitoring Sampling Plan in 2007 and Operational Measures of Residue Monitoring Sampling. Issued by Ministry of Agriculture, Administrative Regulations of the People's Republic of China on Veterinary Medicine. 2007, No. 7.
[7]
Information on http://ec.europa.eu/food/food/rapidalert/index_en.htm
[8]
McCrackena, R., Hannab, B., Ennisa, D. The occurrence of semicarbazide in the muscle and shell of Bangladeshi fresh-water shrimp. Food Chem. 2011, 25, 1-6.
[9]
Poucke,C. Van, DE Tavernier, C. Investigation into the Possible Natural Occurrence of Semicarbazide in Macrobrachium rosenbergii Prawns. J. Agric. Food Chem. 2011, 59, 2107–2112.
[10]
Leitner, A., Zollner, P., Lindner, W. Determination of the metabolites of nitrofuran antibiotics in animal tissue by high-performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. 2001, 939, 49–58.
[11]
Cooper, K. M., Mulder, P.P., Rhijn, J. A. van. Depletion of four nitrofuran antibiotics and their tissue-bound metabolites in porcine tissues and determination using LC-MS/MS and HPLC-UV. Food Addit Contam. 2005, 22(5), 406-414.
[12]
Hu, Q. Z., Noll, R. J., Li, H. Y.; Makarov, A. The Orbitrap: a new mass spectrometer. J. Mass Spectrom. 2005, 40, 430–443.
[13]
Nielen, M. W. F., Engelen, M.C. van; Zuiderent, R., Ramaker. R. Screening and confirmation criteria for hormone residue analysis using liquid chromatography accurate mass time-of-flight, Fourier transform ion cyclotron resonance and orbitrap mass spectrometry techniques. Analytica Chimica Acta. 2007, 586(14)122–129.
[14]
Heeft, E. van, Bolck, Y. J. C., Beumer, B. Full-Scan Accurate Mass Selectivity of Ultra-Performance Liquid Chromatography Combined with Time-of-Flight and Orbitrap Mass Spectrometry in Hormone and Veterinary Drug Residue Analysis. Journal of the American Society for Mass Spectrometry. 2009, 20(3), 451–463.
[15]
Makarov, A, Scigelova, M. Coupling liquid chromatography to Orbitrap mass spectrometry. Journal of Chromatography A. 2010, 1217(25), 3938–3945.
[16]
Announcement by the Ministry of Agriculture No.31, People's Republic of China.
[17]
European Commission, Commission Decision 2002/657/EC. Off. J. Eur. Communities.
[18]
Yu H. J.;Li B.; Cai Y. Q. Determination of Semicarbazide content in crustaceans by Liquid chromatography tandem mass spectrometry. Chinese Journal of Analytical Chemistry. 2012, 4(10), 1530-1535.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186