MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping

Guo Hongyu; Wang Yanjun; Huang Ping; Guo Hua

doi:doi:10.11648/j.sd.20160406.20

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MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping

Guo Hongyu, Wang Yanjun, Huang Ping, Guo Hua

Published in Science Discovery (Volume 4, Issue 6)

Received: 6 December 2016 Accepted: Published: 7 December 2016

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Abstract

Purpose: MRI(Magnetic Resonance Imaging) estimates of brain iron deposition in thalassaemia patient using quantitative susceptibility mapping (QSM) and T2*-weighted methods. And to compare the two methods, if they have feasibility. Thirty-three thalassaemia patients underwent gradient echo sequence on the MR (Magnetic Resonance) scanner with whole-brain coverage to obtain the image data. Then to process the images and calculate the brain iron content using QSM (Quantitative Susceptibility Mapping) and T2*-weighted methods. Both images using QSM and T2* methods can clearly see the distribution of iron in the brain. But T2*-weighted method is less sensitivity for the detection of brain iron content, and only QSM method can quantify the iron content quickly and accurately. The tissue iron can affect the value of T2*, so T2*-weighted method can only detect the distribution of iron content. While the application of magnetic sensitive quantitative imaging can be very effective in routine non-invasive assessment of tissue components, especially iron, that is very important for the assessment of thalassemia patients.

Published in	Science Discovery (Volume 4, Issue 6)
DOI	10.11648/j.sd.20160406.20
Page(s)	405-409
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Quantitative Susceptibility Mapping, T2*-Weighted Mapping, Magnetic Resonance Imaging, Thalassaemia, Iron Concentration

References

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[3]	Schenck J. F., Dumoulin C. L., Redington R. W., Kressel H. Y., Elliott R. T., McDougall I. L. Human exposure to 4.0-Tesla magnetic fields in a whole-body scanner. Med. Phys. 1992;19: 1089–1098.
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[14]	Li W, Wu B, Liu C. Quantitative susceptibility mapping of human brain reflects spatial variation in tisse composition. Neuroimage. 2011;55:1645-1656.
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APA Style

Guo Hongyu, Wang Yanjun, Huang Ping, Guo Hua. (2016). MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping. Science Discovery, 4(6), 405-409. https://doi.org/10.11648/j.sd.20160406.20

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ACS Style

Guo Hongyu; Wang Yanjun; Huang Ping; Guo Hua. MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping. Sci. Discov. 2016, 4(6), 405-409. doi: 10.11648/j.sd.20160406.20

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AMA Style

Guo Hongyu, Wang Yanjun, Huang Ping, Guo Hua. MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping. Sci Discov. 2016;4(6):405-409. doi: 10.11648/j.sd.20160406.20

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@article{10.11648/j.sd.20160406.20,
  author = {Guo Hongyu and Wang Yanjun and Huang Ping and Guo Hua},
  title = {MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping},
  journal = {Science Discovery},
  volume = {4},
  number = {6},
  pages = {405-409},
  doi = {10.11648/j.sd.20160406.20},
  url = {https://doi.org/10.11648/j.sd.20160406.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20160406.20},
  abstract = {Purpose: MRI(Magnetic Resonance Imaging) estimates of brain iron deposition in thalassaemia patient using quantitative susceptibility mapping (QSM) and T2*-weighted methods. And to compare the two methods, if they have feasibility. Thirty-three thalassaemia patients underwent gradient echo sequence on the MR (Magnetic Resonance) scanner with whole-brain coverage to obtain the image data. Then to process the images and calculate the brain iron content using QSM (Quantitative Susceptibility Mapping) and T2*-weighted methods. Both images using QSM and T2* methods can clearly see the distribution of iron in the brain. But T2*-weighted method is less sensitivity for the detection of brain iron content, and only QSM method can quantify the iron content quickly and accurately. The tissue iron can affect the value of T2*, so T2*-weighted method can only detect the distribution of iron content. While the application of magnetic sensitive quantitative imaging can be very effective in routine non-invasive assessment of tissue components, especially iron, that is very important for the assessment of thalassemia patients.},
 year = {2016}
}

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TY  - JOUR
T1  - MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping
AU  - Guo Hongyu
AU  - Wang Yanjun
AU  - Huang Ping
AU  - Guo Hua
Y1  - 2016/12/07
PY  - 2016
N1  - https://doi.org/10.11648/j.sd.20160406.20
DO  - 10.11648/j.sd.20160406.20
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 405
EP  - 409
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20160406.20
AB  - Purpose: MRI(Magnetic Resonance Imaging) estimates of brain iron deposition in thalassaemia patient using quantitative susceptibility mapping (QSM) and T2*-weighted methods. And to compare the two methods, if they have feasibility. Thirty-three thalassaemia patients underwent gradient echo sequence on the MR (Magnetic Resonance) scanner with whole-brain coverage to obtain the image data. Then to process the images and calculate the brain iron content using QSM (Quantitative Susceptibility Mapping) and T2*-weighted methods. Both images using QSM and T2* methods can clearly see the distribution of iron in the brain. But T2*-weighted method is less sensitivity for the detection of brain iron content, and only QSM method can quantify the iron content quickly and accurately. The tissue iron can affect the value of T2*, so T2*-weighted method can only detect the distribution of iron content. While the application of magnetic sensitive quantitative imaging can be very effective in routine non-invasive assessment of tissue components, especially iron, that is very important for the assessment of thalassemia patients.
VL  - 4
IS  - 6
ER  -

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Author Information

Guo Hongyu

Biomedical Engineering, Shenyang University of Technology, Shenyang, China
Wang Yanjun

Electrical Engineering, Shenyang University of Technology, Shenyang, China
Huang Ping

Biomedical Engineering, Shenyang University of Technology, Shenyang, China
Guo Hua

Center for Biomedical Imaging Research, Tsinghua University, Beijing, China

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Plain Text BibTeX RIS

APA Style

Guo Hongyu, Wang Yanjun, Huang Ping, Guo Hua. (2016). MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping. Science Discovery, 4(6), 405-409. https://doi.org/10.11648/j.sd.20160406.20

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ACS Style

Guo Hongyu; Wang Yanjun; Huang Ping; Guo Hua. MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping. Sci. Discov. 2016, 4(6), 405-409. doi: 10.11648/j.sd.20160406.20

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AMA Style

Guo Hongyu, Wang Yanjun, Huang Ping, Guo Hua. MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping. Sci Discov. 2016;4(6):405-409. doi: 10.11648/j.sd.20160406.20

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@article{10.11648/j.sd.20160406.20,
  author = {Guo Hongyu and Wang Yanjun and Huang Ping and Guo Hua},
  title = {MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping},
  journal = {Science Discovery},
  volume = {4},
  number = {6},
  pages = {405-409},
  doi = {10.11648/j.sd.20160406.20},
  url = {https://doi.org/10.11648/j.sd.20160406.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20160406.20},
  abstract = {Purpose: MRI(Magnetic Resonance Imaging) estimates of brain iron deposition in thalassaemia patient using quantitative susceptibility mapping (QSM) and T2*-weighted methods. And to compare the two methods, if they have feasibility. Thirty-three thalassaemia patients underwent gradient echo sequence on the MR (Magnetic Resonance) scanner with whole-brain coverage to obtain the image data. Then to process the images and calculate the brain iron content using QSM (Quantitative Susceptibility Mapping) and T2*-weighted methods. Both images using QSM and T2* methods can clearly see the distribution of iron in the brain. But T2*-weighted method is less sensitivity for the detection of brain iron content, and only QSM method can quantify the iron content quickly and accurately. The tissue iron can affect the value of T2*, so T2*-weighted method can only detect the distribution of iron content. While the application of magnetic sensitive quantitative imaging can be very effective in routine non-invasive assessment of tissue components, especially iron, that is very important for the assessment of thalassemia patients.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - MRI Detects Brain Iron Deposition in Thalassaemia Patients Using Quantitative Susceptibility Mapping and T2*-Weighted Mapping
AU  - Guo Hongyu
AU  - Wang Yanjun
AU  - Huang Ping
AU  - Guo Hua
Y1  - 2016/12/07
PY  - 2016
N1  - https://doi.org/10.11648/j.sd.20160406.20
DO  - 10.11648/j.sd.20160406.20
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 405
EP  - 409
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20160406.20
AB  - Purpose: MRI(Magnetic Resonance Imaging) estimates of brain iron deposition in thalassaemia patient using quantitative susceptibility mapping (QSM) and T2*-weighted methods. And to compare the two methods, if they have feasibility. Thirty-three thalassaemia patients underwent gradient echo sequence on the MR (Magnetic Resonance) scanner with whole-brain coverage to obtain the image data. Then to process the images and calculate the brain iron content using QSM (Quantitative Susceptibility Mapping) and T2*-weighted methods. Both images using QSM and T2* methods can clearly see the distribution of iron in the brain. But T2*-weighted method is less sensitivity for the detection of brain iron content, and only QSM method can quantify the iron content quickly and accurately. The tissue iron can affect the value of T2*, so T2*-weighted method can only detect the distribution of iron content. While the application of magnetic sensitive quantitative imaging can be very effective in routine non-invasive assessment of tissue components, especially iron, that is very important for the assessment of thalassemia patients.
VL  - 4
IS  - 6
ER  -

Copy | Download