Modification of Chitosan and the Research Progress in Clinical Application

Li Dongdong; Liao Shiqi

doi:doi:10.11648/j.sd.20160406.21

| Peer-Reviewed

Modification of Chitosan and the Research Progress in Clinical Application

Li Dongdong, Liao Shiqi

Published in Science Discovery (Volume 4, Issue 6)

Received: 6 December 2016 Accepted: Published: 7 December 2016

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Chitosan is the only natural basic polysaccharide detected so far, it is a natural polymer chitin to take off the acetylation. Chitin sources rich and content, production capacity of about 10¹³ ~ 10¹⁴ kg of the nature, it is the second largest polysaccharide next to cellulose material. Because not only chitin has three biological functions of decreasing hematic fat, blood pressure and blood sugar, but also has an effect of inhibiting of cancer and anticancer, tumor cells metastasis and improves human immunity and protect liver detoxification. Especially suitable for disease such as diabetes, kidney disease, high blood pressure, obesity etc. In favor of preventing cancer cell lesion and fractionation radiation treatment of tumor diseases. So this article from the characteristics of chitosan, application, preparation of modified and its in clinical application of these four aspects were summarized with a deeper understanding of the biological functions and the research progress of chitosan.

Published in	Science Discovery (Volume 4, Issue 6)
DOI	10.11648/j.sd.20160406.21
Page(s)	410-415
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Chitosan, Use, Modification and Clinical Application

References

[1]	Kumar M N V.A Review of Chitin and Chitosan Applications.[J]Reoct Funct Polym,2000,46:1-27
[2]	GUIBAL E. Heterogeneous catalysis on chitosan-based materials：a review[J]. Progress in Polymer Science，2005，30（1）：71-109.
[3]	A.P. Martínez-Camacho，M.O. Cortez-Rocha，J.M. Ezquerra-Brauer， et al. Chitosan composite films： Thermal， structural，mechanical and antifungal properties[J]. Carbohydrate Polymers，2010，82（2）：305-315.
[4]	黄贵东.壳聚糖及相关产物降脂活性和机制研究[D].广东药学院,2014。
[5]	李珍珠.无瘢痕化医用组织胶的制备及性能研究[D].重庆理工大学,2015。
[6]	戎汨. 壳聚糖衍生物对免疫低下小鼠免疫调节作用的实验研究[D].中国海洋大学,2012。
[7]	陈柔. 壳聚糖基纳米体系的制备及其用作抗肿瘤药物载体的体外研究[D].天津医科大学,2013。
[8]	刘亮亮,刘万顺,韩宝芹,等.壳寡糖、氨基葡萄糖对酒精性肝损伤小鼠的保护作用[J].中国海洋大学学报: 自然科学版.2010,(7):73-76
[9]	方敏.甲壳低聚糖硒的合成及其干预实验性糖尿病鼠模型形成的研究[D].南华大学,2005。
[10]	田清青.壳聚糖固定化血管紧张素转化酶的制备及其应用[D].湖南师范大学,2012.
[11]	肖定福.壳聚糖对仔猪生长、肠道屏障和免疫的影响及其机理研究[D].湖南农业大学,2011.
[12]	周洁.羟肟化杯[6]芳烃上沿负载壳聚糖对铀(Ⅵ)等重金属的吸附作用及机制[D].南华大学,2015。
[13]	舒瑶.心梗微环境适应性壳聚糖基水凝胶的研制及其性能评价[D].中国人民解放军军事医学科学院,2014。
[14]	刘松.壳聚糖衍生物金属配合物的制备及其抑菌、抗氧化活性研究[D].中国科学院研究生院（海洋研究所）,2004。
[15]	周加贝.可载药生物高分子/磷酸钙多孔复合涂层的制备、表征及生物学评价[D].浙江大学,2012。
[16]	李南.几种氨基糖对受损心肌细胞和心肌组织的保护作用[D].中国海洋大学,2013.
[17]	叶光辉.壳聚糖的应用研究进展[J].广州化工.2015,(2):21-22。
[18]	曹丹.壳聚糖纳米粒介导TGF-β1/miR-493靶向干预结直肠癌肝转移的作用及机制研究[D].苏州大学,2015。
[19]	徐闯,王筱菊,王晨宏,等.pH和还原性双响应性壳聚糖纳米粒子作为药物传输载体[J].高分子学报.2015,(1):65-71。
[20]	张雅娟,郑静霞,李娟,等.葡萄糖响应苯硼酸接枝壳聚糖盐酸盐抗肿瘤药物载体[J].高分子学报.2015,(9):1020-1027。
[21]	李瑶.磁性纳米基因工程载体细胞转化方法研究[D].中国农业科学院,2010。
[22]	Hejazy, M.Amiji, M. Chitosan-based gastrointestinal delivery systems Controlled Release, [J] 2010, 89(2): 151-165.
[23]	魏婉楚.壳聚糖的改性及其应用[J].中山大学研究生学刊(自然科学.医学版),2013,01:1-12。
[24]	舒瑶.心梗微环境适应性壳聚糖基水凝胶的研制及其性能评价[D].中国人民解放军军事医学科学院,2014。
[25]	张军丽,李瑞玲,张燕,潘庆才.改性壳聚糖吸附剂的合成及对镉离子的吸附性能[J].环境科学与技术,2011,07:87-89+170。
[26]	赵爱杰，原续波，常津；O-羧甲基壳聚糖的制备及应用研究进展[J];高分子通报；2004-04。
[27]	蔡国伟.壳聚糖缓蚀剂与阴极保护对管线钢的联合作用机制研究[D].中国科学院研究生院(海洋研究所),2015。
[28]	王资盛.羧甲基壳聚糖氟缓释膜实验研究[D].兰州大学,2014。
[29]	Tomihata K, Ikada Y. Biomaterials, 2007, 18(7): 5671.
[30]	王锋,庄昭霞,卢凤崎;改性壳聚糖膜的兔体内组织反应和降解实验[J];山东大学学报(医学版);2002,40(4):3671。
[31]	陈浩凡;潘仕荣;胡瑜;羧甲基壳聚糖体外溶菌酶降解的研究[J];深圳特区科技;2005,8(10):8071。
[32]	Helander IM, Nurmiaho-Lassila EL, Ahvenainen R, et al. Chitosan dis-rupts the barrier properties of the outer membrane of gram-negative bacteria. Int J Food Microbiol, 2011, 71(2-3): 235-244.
[33]	Liu XF, Guan YL, Yang DZ, et al. Antibacterial action of chitosan andcarboxymethylated chitosan. J Appl Polym Sci, 2001, 79(7): 1324-1335.
[34]	Kim K, Thomas RL, Lee C, et al. Antimirobial activity of native chitosan degraded chitosan, and O-carboxymethylated chitosan. [J] Food Prot, 2013, 66(8): 1495-1498.
[35]	Subhankari Prasad Chakraborty, Santanu Kar Mahapatra, et al. Antioxidative effect of folate-modified chitosan nanoparticles [J] Asian Pacific Journal of Tropical Biomedicine 2011, 01
[36]	Yi Hong ，Haiqing Song， Yihong Gong ,et al. Covalently crosslinked chitosan hydrogel: Properties of in vitro degradation and chondrocyte encapsulation[J]Journal of Biomedical Materials Research Part A, 2011, 79(4): 9 13-922.
[37]	杨晋青,郭祀远.交联化羟丙基壳聚糖对Cr(Ⅵ)的吸附与结构分析[J].离子交换与吸附.2010,(3):248-255。
[38]	颜阿娜,李世迁.壳聚糖及其衍生物在食品工农业中的应用研究进展[J].广州化工.2014,(18):8-10。
[39]	逯慎杰,刘秀河.壳聚糖作为绿色饲料添加剂的应用[J].饲料博览.2010,(9):21-23.[40]李平,金兰淑,刘时光.巯基壳聚糖应用进展及农业环境保护展望[J].农业科技与装备.2012,(12):8-10。
[40]	殷思贝,黄庆,府伟灵.新型壳聚糖纳米氧化铁磁珠的制备和理化性能测定[J].细胞与分子免疫学杂志.2013,(6):652-654。

Cite This Article

Plain Text BibTeX RIS

APA Style

Li Dongdong, Liao Shiqi. (2016). Modification of Chitosan and the Research Progress in Clinical Application. Science Discovery, 4(6), 410-415. https://doi.org/10.11648/j.sd.20160406.21

Copy | Download

ACS Style

Li Dongdong; Liao Shiqi. Modification of Chitosan and the Research Progress in Clinical Application. Sci. Discov. 2016, 4(6), 410-415. doi: 10.11648/j.sd.20160406.21

Copy | Download

AMA Style

Li Dongdong, Liao Shiqi. Modification of Chitosan and the Research Progress in Clinical Application. Sci Discov. 2016;4(6):410-415. doi: 10.11648/j.sd.20160406.21

Copy | Download

@article{10.11648/j.sd.20160406.21,
  author = {Li Dongdong and Liao Shiqi},
  title = {Modification of Chitosan and the Research Progress in Clinical Application},
  journal = {Science Discovery},
  volume = {4},
  number = {6},
  pages = {410-415},
  doi = {10.11648/j.sd.20160406.21},
  url = {https://doi.org/10.11648/j.sd.20160406.21},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20160406.21},
  abstract = {Chitosan is the only natural basic polysaccharide detected so far, it is a natural polymer chitin to take off the acetylation. Chitin sources rich and content, production capacity of about 1013 ~ 1014 kg of the nature, it is the second largest polysaccharide next to cellulose material. Because not only chitin has three biological functions of decreasing hematic fat, blood pressure and blood sugar, but also has an effect of inhibiting of cancer and anticancer, tumor cells metastasis and improves human immunity and protect liver detoxification. Especially suitable for disease such as diabetes, kidney disease, high blood pressure, obesity etc. In favor of preventing cancer cell lesion and fractionation radiation treatment of tumor diseases. So this article from the characteristics of chitosan, application, preparation of modified and its in clinical application of these four aspects were summarized with a deeper understanding of the biological functions and the research progress of chitosan.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Modification of Chitosan and the Research Progress in Clinical Application
AU  - Li Dongdong
AU  - Liao Shiqi
Y1  - 2016/12/07
PY  - 2016
N1  - https://doi.org/10.11648/j.sd.20160406.21
DO  - 10.11648/j.sd.20160406.21
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 410
EP  - 415
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20160406.21
AB  - Chitosan is the only natural basic polysaccharide detected so far, it is a natural polymer chitin to take off the acetylation. Chitin sources rich and content, production capacity of about 1013 ~ 1014 kg of the nature, it is the second largest polysaccharide next to cellulose material. Because not only chitin has three biological functions of decreasing hematic fat, blood pressure and blood sugar, but also has an effect of inhibiting of cancer and anticancer, tumor cells metastasis and improves human immunity and protect liver detoxification. Especially suitable for disease such as diabetes, kidney disease, high blood pressure, obesity etc. In favor of preventing cancer cell lesion and fractionation radiation treatment of tumor diseases. So this article from the characteristics of chitosan, application, preparation of modified and its in clinical application of these four aspects were summarized with a deeper understanding of the biological functions and the research progress of chitosan.
VL  - 4
IS  - 6
ER  -

Copy | Download

Author Information

Li Dongdong

Lanzhou University Life Science Institute of Cell Biology, Lanzhou, China
Liao Shiqi

Gansu Province Medical Science Research Institute, Lanzhou, China

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Li Dongdong, Liao Shiqi. (2016). Modification of Chitosan and the Research Progress in Clinical Application. Science Discovery, 4(6), 410-415. https://doi.org/10.11648/j.sd.20160406.21

Copy | Download

ACS Style

Li Dongdong; Liao Shiqi. Modification of Chitosan and the Research Progress in Clinical Application. Sci. Discov. 2016, 4(6), 410-415. doi: 10.11648/j.sd.20160406.21

Copy | Download

AMA Style

Li Dongdong, Liao Shiqi. Modification of Chitosan and the Research Progress in Clinical Application. Sci Discov. 2016;4(6):410-415. doi: 10.11648/j.sd.20160406.21

Copy | Download

@article{10.11648/j.sd.20160406.21,
  author = {Li Dongdong and Liao Shiqi},
  title = {Modification of Chitosan and the Research Progress in Clinical Application},
  journal = {Science Discovery},
  volume = {4},
  number = {6},
  pages = {410-415},
  doi = {10.11648/j.sd.20160406.21},
  url = {https://doi.org/10.11648/j.sd.20160406.21},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20160406.21},
  abstract = {Chitosan is the only natural basic polysaccharide detected so far, it is a natural polymer chitin to take off the acetylation. Chitin sources rich and content, production capacity of about 1013 ~ 1014 kg of the nature, it is the second largest polysaccharide next to cellulose material. Because not only chitin has three biological functions of decreasing hematic fat, blood pressure and blood sugar, but also has an effect of inhibiting of cancer and anticancer, tumor cells metastasis and improves human immunity and protect liver detoxification. Especially suitable for disease such as diabetes, kidney disease, high blood pressure, obesity etc. In favor of preventing cancer cell lesion and fractionation radiation treatment of tumor diseases. So this article from the characteristics of chitosan, application, preparation of modified and its in clinical application of these four aspects were summarized with a deeper understanding of the biological functions and the research progress of chitosan.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Modification of Chitosan and the Research Progress in Clinical Application
AU  - Li Dongdong
AU  - Liao Shiqi
Y1  - 2016/12/07
PY  - 2016
N1  - https://doi.org/10.11648/j.sd.20160406.21
DO  - 10.11648/j.sd.20160406.21
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 410
EP  - 415
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20160406.21
AB  - Chitosan is the only natural basic polysaccharide detected so far, it is a natural polymer chitin to take off the acetylation. Chitin sources rich and content, production capacity of about 1013 ~ 1014 kg of the nature, it is the second largest polysaccharide next to cellulose material. Because not only chitin has three biological functions of decreasing hematic fat, blood pressure and blood sugar, but also has an effect of inhibiting of cancer and anticancer, tumor cells metastasis and improves human immunity and protect liver detoxification. Especially suitable for disease such as diabetes, kidney disease, high blood pressure, obesity etc. In favor of preventing cancer cell lesion and fractionation radiation treatment of tumor diseases. So this article from the characteristics of chitosan, application, preparation of modified and its in clinical application of these four aspects were summarized with a deeper understanding of the biological functions and the research progress of chitosan.
VL  - 4
IS  - 6
ER  -

Copy | Download