Research Progress of Exosome Non-coding RNA in Cancer

Jiajia Jin; Shengrong Wu; Xiaoyan Lu; Zixiao Huang; Mei’e Jia; Xiangyi He

doi:doi:10.11648/j.sd.20190701.13

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Research Progress of Exosome Non-coding RNA in Cancer

Jiajia Jin, Shengrong Wu, Xiaoyan Lu, Zixiao Huang, Mei’e Jia, Xiangyi He

Received: 26 January 2019 Accepted: Published: 8 March 2019

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Abstract

Exosomes, secreted by both normal cells and tumor cells, are small membrane vesicle bodies that presented in saliva, blood, urine and other body fluids. The proteins, lipids, non-coding RNA and other components in exosomes functioned profoundly in cell communication and signal transduction, and tumor-derived exosomes can activate various signaling pathways and influence tumor microenvironment to participate in the tumor proliferation and migration. Non-coding RNAs play a crucial role in regulating gene expression, such as cell physiology, tumor development and tumor immunity. At present, researchs focused on exosome non-coding RNA, especially miRNA and lnRNA. In this review, we will review the tumor-derived exosome miRNA and lnRNA in tumorigenesis and development.

DOI	10.11648/j.sd.20190701.13
Published in	Science Discovery (Volume 7, Issue 1, February 2019)
Page(s)	13-17
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Exosome, Cancer, Non-coding RNA

References

[1]	Sund M, Kalluri R. Tumor stroma derived biomarkers in cancer [J]. Cancer Metastasis Rev, 2009, 28(1-2):177-183.
[2]	Bullock MD, Silva AM, Kanlikilicer-Unaldi P, Filant J, Rashed MH, Sood AK, Lopez-Berestein G, Calin GA. Exosomal Non-Coding RNAs: Diagnostic, Prognostic and Therapeutic Applications in Cancer[J]. Noncoding RNA, 2015, 1(1):53-68.
[3]	Grimaldi A, Zarone MR, Irace C, Zappavigna S, Lombardi A, Kawasaki H, Caraglia M, Misso G. Non-coding RNAs as a new dawn in tumor diagnosis [J]. Semin Cell Dev Biol, 2018, 78:37-50.
[4]	Yang S, Li X. Recent advances in extracellular vesicles enriched with non-coding RNAs related to cancers[J]. Genes & Diseases, 2018, 5(1):36-42.
[5]	Skotland T, Sandvig K, Llorente A. Lipids in exosomes: Current knowledge and the way forward [J]. Prog Lipid Res, 2017, 66:30-41.
[6]	Mercer TR, Mattick JS. Structure and function of long noncoding RNAs in epigenetic regulation [J]. Nat Struct Mol Biol, 2013, 20(3):300-307.
[7]	Yu S, Cao H, Shen B, Feng J. Tumor-derived exosomes in cancer progression and treatment failure [J]. Oncotarget, 2015, 6(35):37151-37168.
[8]	Mathivanan S, Simpson RJ. ExoCarta: A compendium of exosomal proteins and RNA [J]. Proteomics, 2009, 9(21):4997-5000.
[9]	Azmi AS, Bao B, Sarkar FH. Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review [J]. Cancer Metastasis Rev, 2013, 32(3-4):623-642.
[10]	Consortium EP. An integrated encyclopedia of DNA elements in the human genome [J]. Nature, 2012, 489(7414):57-74.
[11]	谢兆辉. 长非编码RNA在基因表达调节中的作用[J]. 生命的化学, 2010, 30(3):345-349.
[12]	Milane L, Singh A, Mattheolabakis G, Suresh M, Amiji MM. Exosome mediated communication within the tumor microenvironment [J]. J Control Release, 2015, 219:278-294.
[13]	DP B. MicroRNAs: genomics, biogenesis, mechanism, and function [J]. Cell Biol Int, 2004, 116(2):281-297.
[14]	Ha M, Kim VN. Regulation of microRNA biogenesis[J]. Nat Rev Mol Cell Biol, 2014, 15(8):509-524.
[15]	Théry C. Exosomes,secreted vesicles and intercellular communications [J]. F1000 Biol Rep, 2011, 3(15).
[16]	Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall J. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells [J]. Nature Cell Biology, 2007, 9(6):654-659.
[17]	Kogure T, Lin WL, Yan IK, Braconi C, Patel T. Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth [J]. Hepatology, 2011, 54(4):1237-1248.
[18]	van Balkom BW, de Jong OG, Smits M et al. Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells [J]. Blood, 2013, 121(19):3997-4006, S3991-3915.
[19]	Pang W, Su J, Wang Y, Feng H, Dai X, Yuan Y, Chen X, Yao W. Pancreatic cancer-secreted miR-155 implicates in the conversion from normal fibroblasts to cancer-associated fibroblasts [J]. Cancer Sci, 2015, 106(10):1362-1369.
[20]	Li L, Li C, Wang S et al. Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype[J]. Cancer Res, 2016, 76(7):1770-1780.
[21]	Hsu YL, Hung JY, Chang WA, Lin YS, Pan YC, Tsai PH, Wu CY, Kuo PL. Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1[J]. Oncogene, 2017, 36(34):4929-4942.
[22]	Fabbri M, Paone A, Calore F et al. MicroRNAs bind to Toll-like receptors to induce pro- metastatic inflammatory response[J]. Proc Natl Acad Sci USA, 2012, 109(31):E2110-2116.
[23]	Ogata-Kawata H, Izumiya M, Kurioka D et al. Circulating exosomal microRNAs as biomarkers of colon cancer[J]. PLoS One, 2014, 9(4):e92921.
[24]	Moran VA, Perera RJ, Khalil AM. Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs[J]. Nucleic Acids Res, 2012, 40(14):6391-6400.
[25]	韩奕能. 长链非编码RNA与口腔癌研究进展.[J]. 临床与病理杂志, 2016, 36(9):1450-1456.
[26]	Gezer U, Ozgur E, Cetinkaya M, Isin M, Dalay N. Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes[J]. Cell Biol Int, 2014, 38(9):1076-1079.
[27]	Ji P, Diederichs S, Wang W et al. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer[J]. Oncogene, 2003, 22(39):8031-8041.
[28]	Han Y, Liu Y, Nie L, Gui Y, Cai Z. Inducing cell proliferation inhibition, apoptosis, and motility reduction by silencing long noncoding ribonucleic acid metastasis-associated lung adenocarcinoma transcript 1 in urothelial carcinoma of the bladder[J]. Urology, 2013, 81(1):209 e201-207.
[29]	Gupta RA, Shah N, Wang KC et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis[J]. Nature, 2010, 464(7291):1071-1076.
[30]	Hayami S, Kelly JD, Cho HS et al. Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers[J]. Int J Cancer, 2011, 128(3):574-586.
[31]	Yang F, Xue X, Bi J, Zheng L, Zhi K, Gu Y, Fang G. Long noncoding RNA CCAT1, which could be activated by c-Myc, promotes the progression of gastric carcinoma.[J]. J Cancer Res Clin Oncol, 2013, 139(3):437-445.
[32]	Qiu M, Xu Y, Yang X, Wang J, Hu J, Xu L, Yin R. CCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small cell lung cancer[J]. Tumour Biol, 2014, 35(6):5375-5380.
[33]	Gibb EA, Enfield KS, Stewart GL et al. Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions[J]. Oral Oncol, 2011, 47(11):1055-1061.
[34]	Tang H, Wu Z, Zhang J, Su B. Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis[J]. Mol Med Rep, 2013, 7(3):761-766.

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APA Style

Jiajia Jin, Shengrong Wu, Xiaoyan Lu, Zixiao Huang, Mei’e Jia, et al. (2019). Research Progress of Exosome Non-coding RNA in Cancer. Science Discovery, 7(1), 13-17. https://doi.org/10.11648/j.sd.20190701.13

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ACS Style

Jiajia Jin; Shengrong Wu; Xiaoyan Lu; Zixiao Huang; Mei’e Jia, et al. Research Progress of Exosome Non-coding RNA in Cancer. Sci. Discov. 2019, 7(1), 13-17. doi: 10.11648/j.sd.20190701.13

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AMA Style

Jiajia Jin, Shengrong Wu, Xiaoyan Lu, Zixiao Huang, Mei’e Jia, et al. Research Progress of Exosome Non-coding RNA in Cancer. Sci Discov. 2019;7(1):13-17. doi: 10.11648/j.sd.20190701.13

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@article{10.11648/j.sd.20190701.13,
  author = {Jiajia Jin and Shengrong Wu and Xiaoyan Lu and Zixiao Huang and Mei’e Jia and Xiangyi He},
  title = {Research Progress of Exosome Non-coding RNA in Cancer},
  journal = {Science Discovery},
  volume = {7},
  number = {1},
  pages = {13-17},
  doi = {10.11648/j.sd.20190701.13},
  url = {https://doi.org/10.11648/j.sd.20190701.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20190701.13},
  abstract = {Exosomes, secreted by both normal cells and tumor cells, are small membrane vesicle bodies that presented in saliva, blood, urine and other body fluids. The proteins, lipids, non-coding RNA and other components in exosomes functioned profoundly in cell communication and signal transduction, and tumor-derived exosomes can activate various signaling pathways and influence tumor microenvironment to participate in the tumor proliferation and migration. Non-coding RNAs play a crucial role in regulating gene expression, such as cell physiology, tumor development and tumor immunity. At present, researchs focused on exosome non-coding RNA, especially miRNA and lnRNA. In this review, we will review the tumor-derived exosome miRNA and lnRNA in tumorigenesis and development.},
 year = {2019}
}

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TY  - JOUR
T1  - Research Progress of Exosome Non-coding RNA in Cancer
AU  - Jiajia Jin
AU  - Shengrong Wu
AU  - Xiaoyan Lu
AU  - Zixiao Huang
AU  - Mei’e Jia
AU  - Xiangyi He
Y1  - 2019/03/08
PY  - 2019
N1  - https://doi.org/10.11648/j.sd.20190701.13
DO  - 10.11648/j.sd.20190701.13
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 13
EP  - 17
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20190701.13
AB  - Exosomes, secreted by both normal cells and tumor cells, are small membrane vesicle bodies that presented in saliva, blood, urine and other body fluids. The proteins, lipids, non-coding RNA and other components in exosomes functioned profoundly in cell communication and signal transduction, and tumor-derived exosomes can activate various signaling pathways and influence tumor microenvironment to participate in the tumor proliferation and migration. Non-coding RNAs play a crucial role in regulating gene expression, such as cell physiology, tumor development and tumor immunity. At present, researchs focused on exosome non-coding RNA, especially miRNA and lnRNA. In this review, we will review the tumor-derived exosome miRNA and lnRNA in tumorigenesis and development.
VL  - 7
IS  - 1
ER  -

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Author Information

Jiajia Jin

School of Dentistry, Lanzhou University, Lanzhou, P. R. China
Shengrong Wu

School of Dentistry, Lanzhou University, Lanzhou, P. R. China
Xiaoyan Lu

School of Dentistry, Lanzhou University, Lanzhou, P. R. China
Zixiao Huang

School of Dentistry, Lanzhou University, Lanzhou, P. R. China
Mei’e Jia

School of Dentistry, Lanzhou University, Lanzhou, P. R. China
Xiangyi He

School of Dentistry, Lanzhou University, Lanzhou, P. R. China

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Plain Text BibTeX RIS

APA Style

Jiajia Jin, Shengrong Wu, Xiaoyan Lu, Zixiao Huang, Mei’e Jia, et al. (2019). Research Progress of Exosome Non-coding RNA in Cancer. Science Discovery, 7(1), 13-17. https://doi.org/10.11648/j.sd.20190701.13

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ACS Style

Jiajia Jin; Shengrong Wu; Xiaoyan Lu; Zixiao Huang; Mei’e Jia, et al. Research Progress of Exosome Non-coding RNA in Cancer. Sci. Discov. 2019, 7(1), 13-17. doi: 10.11648/j.sd.20190701.13

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AMA Style

Jiajia Jin, Shengrong Wu, Xiaoyan Lu, Zixiao Huang, Mei’e Jia, et al. Research Progress of Exosome Non-coding RNA in Cancer. Sci Discov. 2019;7(1):13-17. doi: 10.11648/j.sd.20190701.13

Copy | Download

@article{10.11648/j.sd.20190701.13,
  author = {Jiajia Jin and Shengrong Wu and Xiaoyan Lu and Zixiao Huang and Mei’e Jia and Xiangyi He},
  title = {Research Progress of Exosome Non-coding RNA in Cancer},
  journal = {Science Discovery},
  volume = {7},
  number = {1},
  pages = {13-17},
  doi = {10.11648/j.sd.20190701.13},
  url = {https://doi.org/10.11648/j.sd.20190701.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20190701.13},
  abstract = {Exosomes, secreted by both normal cells and tumor cells, are small membrane vesicle bodies that presented in saliva, blood, urine and other body fluids. The proteins, lipids, non-coding RNA and other components in exosomes functioned profoundly in cell communication and signal transduction, and tumor-derived exosomes can activate various signaling pathways and influence tumor microenvironment to participate in the tumor proliferation and migration. Non-coding RNAs play a crucial role in regulating gene expression, such as cell physiology, tumor development and tumor immunity. At present, researchs focused on exosome non-coding RNA, especially miRNA and lnRNA. In this review, we will review the tumor-derived exosome miRNA and lnRNA in tumorigenesis and development.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Research Progress of Exosome Non-coding RNA in Cancer
AU  - Jiajia Jin
AU  - Shengrong Wu
AU  - Xiaoyan Lu
AU  - Zixiao Huang
AU  - Mei’e Jia
AU  - Xiangyi He
Y1  - 2019/03/08
PY  - 2019
N1  - https://doi.org/10.11648/j.sd.20190701.13
DO  - 10.11648/j.sd.20190701.13
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 13
EP  - 17
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20190701.13
AB  - Exosomes, secreted by both normal cells and tumor cells, are small membrane vesicle bodies that presented in saliva, blood, urine and other body fluids. The proteins, lipids, non-coding RNA and other components in exosomes functioned profoundly in cell communication and signal transduction, and tumor-derived exosomes can activate various signaling pathways and influence tumor microenvironment to participate in the tumor proliferation and migration. Non-coding RNAs play a crucial role in regulating gene expression, such as cell physiology, tumor development and tumor immunity. At present, researchs focused on exosome non-coding RNA, especially miRNA and lnRNA. In this review, we will review the tumor-derived exosome miRNA and lnRNA in tumorigenesis and development.
VL  - 7
IS  - 1
ER  -

Copy | Download