World Journal of Applied Chemistry

| Peer-Reviewed |

Synthesis, Characterisation and Biological Activity of Mixed Ligand Complex of Ni(II) with Furfuralurea and Thiourea

Received: 10 October 2016    Accepted: 01 November 2016    Published: 23 November 2016
Views:       Downloads:

Share This Article

Abstract

A novel mixed ligand complex of the type [M(FU)2A2] where M is Ni(II), FU is furfuralurea and A is thiourea was synthesized, characterized by solubility test, melting point, conductivity measurement, infrared and UV/Vis spectroscopy. The mixed ligand complex of the Ni II was also tested against Proteus mirabilis, Staphlococus aureus, E. coli, Klebsiella pneumonia and Pseudomonas aeriginosa. The in vitro evaluation of the biological studies of the mixed ligand complex showed greater activity against Proteus mirabilis and Klebsiella pneumonia at 60 ug/ml/disc with the minimum zone of inhibition of 13mm and 14mm respectively. The conductivity measurement revealed that the complex is a non electrolyte. The different shade of colour of the complex from the ligand, the shift of the band of the carbonyl functional group to a lower wavelength are evidences of coordination between the metal and the ligands. An octahedral geometry was suggested for the complex. The solubility test shows that the complex is soluble in methanol and dimethylsulphoxide.

DOI 10.11648/j.wjac.20160101.14
Published in World Journal of Applied Chemistry (Volume 1, Issue 1, November 2016)
Page(s) 22-25
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Nickel, Mixed Ligand Complex, Antimicrobial, Furfuralurea, Coordination Compounds

References
[1] Sangita S, Jayesh R, Jasmin B, Neha P, Khusubu T, et. al (2011) Synthesis, characterization and antimicrobial activity of some transition metal complexes (Mn, Co, Zn, Ni) with L-proline and Kojic acid. Advances in Applied Science Research, 2 (4): 374-382.
[2] Fayad NK, Taghreed HA Ghanim FH(2012) Synthesis, characterization and antibacterial activities of Manganese II CoII, IronII, NickelII Zn II and CadmiumII mixed ligand complexes containingamino acid (L-Valine) and saccharin. Advance in Physics Theories and Applications. 9: 1-4.
[3] Yosuva SM, Sabastiyan A (2012) Synthesis, characterization and antimicrobial activity of Cobalt II, and Nickel II complexes with a novel mannich base 2-(diethylaminomethyl)isoindoline-1, 3-dione. International Journal of Chemtech Research, 4 (2): 805-815.
[4] Neeraj S, Ravi P, Chaturvedi K (2012) Spectroscopic and antimicrobial studies of mixed ligand complexes of transition metal (II) ions with nitro quinoline and dibenzoyl methane. Sci. Revs. Chem. Commun., 2 (2): 108-114.
[5] Sanap SV, Patil RM (2013) Synthesis, characterization and biological activity of chiral mixed ligand Ni (II) complexes. Research Journal of Pharmaceutical Sci. 2 (1): 1-10.
[6] Ajay RP, Kamini JD, Sambhaji SR, Vishwanath RP, Rama SL (2012) Synthesis characterization and biological activity of mixed ligand Co(II) complexes of Schiff base 2-amino-4-nitrophenol-n-salicylidene with some amino acids. J. Chem. Pharm. Res. 4 (2): 1413-1425.
[7] Geary WJ, (1997) Use of conductivity measurements in organic solvents for the characterization of coordination compounds. Coord. Chem. Rev. 7: 81-122.
[8] Khanol K, Jahagirdar DV, Khanolkar DD (1973) Mixed ligand chelates of uranyl ion. J. Inorg. Nucl. Chem. 35 (3): 931-940.
[9] Bruce MR, Ronaldo P (1974) Some factors influencing mixed ligand complex formation. J. Inorg. Nucl. Chem. 36: 1665-1670.
[10] Malik GS, Singh SP, Tandon JP (1977) Studies on the mixed ligand complexes involving ligands of biological importance [Ni (II), Zn (II), or Cd (II) 1-10 phenanthroline-amino acids]. J. Inorg. Nucl. Chem. 39 (7): 1279-1982.
[11] Agwara MO, Ndifon MT, Ndosori NB, Paboudam AG, Yufanyi DM et al. (2010) Synthesis, characterization and antimicrobial activity of Co (II), Cu (II), and Zn (II) mixed ligand complexes containing 1,10-phenanthroline and 2, 2-bipyridin. Chem. Soc. Of Ethiopia. 24 (3): 383-389.
[12] Omojola MO (1993) Modification of urea with maize cob waste for use as slow release nitrogen fertilizer. Ph. D. Thesis; Ahmadu Bello University, Zaria, Nigeria.
[13] Idoko O, Thomas SA (2007) Preparation and characterization of furfural-urea metal complexes of Ni(II) and Co (II). B. Sc. Thesis; university of Abuja, Nigeria.
[14] Hamrit H, Ojebba-sid S, Benli-Baitich O, Khan MA, Bouet GM (2000). Potentiometric studies, synthesis and characterization of mixed ligand complexes of Cu (II), Ni (II), Co (II) and Mn (II) with N-acetomidioiminodiacetic acid as the primary ligand and histidine as the secondary one. Synth. React. Inorg. Met-Org. Chem. 30 (10): 1835-1848.
[15] Iniama GE, Offiong OE, Nfor E, Ayi AA (2007) Mixed ligand complexes of Nickel (II) with 2-acetylpyridine thiosemicarbonzone and some N/S monodentate ligands: synthesis, structural characterization and biological activity. Proceedings of the 30th annual international conference of chemical society of Nigeria (CSN) Abuja, Nigeria.
[16] Clinical Laboratory Standard institute/national committee for clinical laboratory standard 2006.
[17] European committee on antimicrobial susceptibility testing, version 2.1, 2012.
[18] Alimarin IP, and Shlenskaya VI. (1996). The analytical chemistry of mixed ligand complexes. Institute of Analytical Chemistry, M. V. Lomonosov Mosco State.
[19] Osunlaya AA, Ndahi NP and Ameh JA. (2007). Physico-chemical and antimicrobial properties of CoII, NiII and CuII mixed ligand complexes of dimethylglyoxime. Proceedings of the 30th annual international conference of chemical society of Nigeria. 89 – 98.
[20] Faridul I, Amran H, Nur MS, Hridika TB, Alagir K, Mohammad JK and Romel M. (2015). Synthesis, characterization, and antimicrobial activity studies of Ni (II) complex with pyridine as a ligand. Journal of Chemistry. 2015 (2015).
[21] Jegede CA. (2005). Synthesis, characterization, and biological studies of some metal fluoroquinolone complexes, PhD thesis, University of Ilorin, Kwara State, Nigeria.
Author Information
  • Sheda Science and Technology Complex, Sheda, Abuja, Nigeria

  • Sheda Science and Technology Complex, Sheda, Abuja, Nigeria

  • Sheda Science and Technology Complex, Sheda, Abuja, Nigeria

  • Sheda Science and Technology Complex, Sheda, Abuja, Nigeria

Cite This Article
  • APA Style

    Idoko Owoicho, Emmanuel Stella, Abubakar Salisu, Thomas Sunday Asuquo. (2016). Synthesis, Characterisation and Biological Activity of Mixed Ligand Complex of Ni(II) with Furfuralurea and Thiourea. World Journal of Applied Chemistry, 1(1), 22-25. https://doi.org/10.11648/j.wjac.20160101.14

    Copy | Download

    ACS Style

    Idoko Owoicho; Emmanuel Stella; Abubakar Salisu; Thomas Sunday Asuquo. Synthesis, Characterisation and Biological Activity of Mixed Ligand Complex of Ni(II) with Furfuralurea and Thiourea. World J. Appl. Chem. 2016, 1(1), 22-25. doi: 10.11648/j.wjac.20160101.14

    Copy | Download

    AMA Style

    Idoko Owoicho, Emmanuel Stella, Abubakar Salisu, Thomas Sunday Asuquo. Synthesis, Characterisation and Biological Activity of Mixed Ligand Complex of Ni(II) with Furfuralurea and Thiourea. World J Appl Chem. 2016;1(1):22-25. doi: 10.11648/j.wjac.20160101.14

    Copy | Download

  • @article{10.11648/j.wjac.20160101.14,
      author = {Idoko Owoicho and Emmanuel Stella and Abubakar Salisu and Thomas Sunday Asuquo},
      title = {Synthesis, Characterisation and Biological Activity of Mixed Ligand Complex of Ni(II) with Furfuralurea and Thiourea},
      journal = {World Journal of Applied Chemistry},
      volume = {1},
      number = {1},
      pages = {22-25},
      doi = {10.11648/j.wjac.20160101.14},
      url = {https://doi.org/10.11648/j.wjac.20160101.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.wjac.20160101.14},
      abstract = {A novel mixed ligand complex of the type [M(FU)2A2] where M is Ni(II), FU is furfuralurea and A is thiourea was synthesized, characterized by solubility test, melting point, conductivity measurement, infrared and UV/Vis spectroscopy. The mixed ligand complex of the Ni II was also tested against Proteus mirabilis, Staphlococus aureus, E. coli, Klebsiella pneumonia and Pseudomonas aeriginosa. The in vitro evaluation of the biological studies of the mixed ligand complex showed greater activity against Proteus mirabilis and Klebsiella pneumonia at 60 ug/ml/disc with the minimum zone of inhibition of 13mm and 14mm respectively. The conductivity measurement revealed that the complex is a non electrolyte. The different shade of colour of the complex from the ligand, the shift of the band of the carbonyl functional group to a lower wavelength are evidences of coordination between the metal and the ligands. An octahedral geometry was suggested for the complex. The solubility test shows that the complex is soluble in methanol and dimethylsulphoxide.},
     year = {2016}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Synthesis, Characterisation and Biological Activity of Mixed Ligand Complex of Ni(II) with Furfuralurea and Thiourea
    AU  - Idoko Owoicho
    AU  - Emmanuel Stella
    AU  - Abubakar Salisu
    AU  - Thomas Sunday Asuquo
    Y1  - 2016/11/23
    PY  - 2016
    N1  - https://doi.org/10.11648/j.wjac.20160101.14
    DO  - 10.11648/j.wjac.20160101.14
    T2  - World Journal of Applied Chemistry
    JF  - World Journal of Applied Chemistry
    JO  - World Journal of Applied Chemistry
    SP  - 22
    EP  - 25
    PB  - Science Publishing Group
    SN  - 2637-5982
    UR  - https://doi.org/10.11648/j.wjac.20160101.14
    AB  - A novel mixed ligand complex of the type [M(FU)2A2] where M is Ni(II), FU is furfuralurea and A is thiourea was synthesized, characterized by solubility test, melting point, conductivity measurement, infrared and UV/Vis spectroscopy. The mixed ligand complex of the Ni II was also tested against Proteus mirabilis, Staphlococus aureus, E. coli, Klebsiella pneumonia and Pseudomonas aeriginosa. The in vitro evaluation of the biological studies of the mixed ligand complex showed greater activity against Proteus mirabilis and Klebsiella pneumonia at 60 ug/ml/disc with the minimum zone of inhibition of 13mm and 14mm respectively. The conductivity measurement revealed that the complex is a non electrolyte. The different shade of colour of the complex from the ligand, the shift of the band of the carbonyl functional group to a lower wavelength are evidences of coordination between the metal and the ligands. An octahedral geometry was suggested for the complex. The solubility test shows that the complex is soluble in methanol and dimethylsulphoxide.
    VL  - 1
    IS  - 1
    ER  - 

    Copy | Download

  • Sections