Improvement of the Maximum Avoidance of Inbreeding by the Use of Cell Manipulation Technique in Gametogenesis

Takeshi Honda; Kenji Oyama

doi:doi:10.11648/j.avs.20190704.14

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Improvement of the Maximum Avoidance of Inbreeding by the Use of Cell Manipulation Technique in Gametogenesis

Takeshi Honda, Kenji Oyama

Published in Animal and Veterinary Sciences (Volume 7, Issue 4)

Received: 24 July 2019 Accepted: 13 August 2019 Published: 26 August 2019

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Abstract

Reduction of genetic drift for preservation of genetic variability is one of the primary concerns for maintenance of endangered species in captivity. For this purpose, a number of selection schemes to equalize parental contributions to the next generation have been widely accepted as a simple guideline, but genetic drift due to random segregation of heterozygote parents, so-called Mendelian sampling, has remained unavoidable. In the past, the use of cell manipulation techniques developed in a field of mammal reproductive technology has been suggested to restrict this genetic drift. However, its potential benefit has been examined only for a randomly mating population of equal sex ratio. In this study, we assumed the situation where the cell manipulation technique is applied to the population under the mating system of maximum avoidance of inbreeding (MAI), and examined its effect on the progress of inbreeding by developing a recurrence equation of panmictic indices of the population. Inbreeding coefficient was substantially suppressed at the locus site where the mean number of crossovers between the site and centromere (m) was small. Although inbreeding coefficient inflated as m increased, its effect diminished as m increased. These tendencies were observed irrespective of the size of the population.

Published in	Animal and Veterinary Sciences (Volume 7, Issue 4)
DOI	10.11648/j.avs.20190704.14
Page(s)	99-103
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Maximum Avoidance of Inbreeding, Mendelian Sampling, Recurrence Equation, Cell Manipulation Technique, Gametogenesis

References

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[5]	Caballero, A., Toro, M. A., 2000. Interrelations between effective population size and other pedigree tools for management of conserved populations. Genet. Res. 75, 331-343.
[6]	Fernández, J., Caballero, A., 2001. Accumulation of deleterious mutations and equalization of parental contributions in the conservation of genetic resources. Heredity 86, 480-488.
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[8]	Wang, J., 1997. More efficient breeding systems for controlling inbreeding and effective size in animal populations. Heredity 79, 591-599.
[9]	Wang, J., Hill, W. G., 2000. Marker assisted selection to increase effective population size by reducing Mendelian segregation variance. Genetics 154, 475-489.
[10]	Santiago, E., Caballero, A., 2000. Application of reproduction technologies to the conservation of genetic resources. Conserv. Biol. 14, 1831-1836.
[11]	Wakayama, T., Hayashi, Y., Ogura, A., 1997. Participation of the female pronucleus derived from the secondary polar body in full embryonic development of mice. J. Reprod. Fert. 110, 263-266.
[12]	Wakayama, T., Yanagimachi, R., 1998. The first polar body can be used for the production of normal offspring in mice. Biol. Reprod. 59, 100-104.
[13]	Tesarik, J., Bahceci, M., Özcan, C., Greco, E., and Mendoza, C., 1999. Restoration of fertility by in-vitro spermatogenesis. The Lancet 353, 555-556.
[14]	Ogura, A., Suzuki, O., Tanemura, K., Mochida, K., Kobayashi, Y., and Matsuda, J., 1998. Development of normal mice from metaphase I oocytes fertilized with primary spermatocytes. Proc. Natl. Acad. Sci. U. S. A. 95, 5611-5615.
[15]	Kimura, M., Crow, J., 1963. On the maximum avoidance of inbreeding. Genet. Res. 4, 399-415.
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[18]	Ballou, J. D., Foose, T. J., 1995. Demographic and genetic management of captive populations. In: Kleinman, D. G., Lumpkin, S., Allen, M., Harris, H., Thompson, K. (eds), Wild Mammals in Captivity. University of Chicago Press, Chicago, pp. 263-283.
[19]	Ballou, J. D., Lacy, R. C., 1995. Identifying genetically important individuals for management of genetic variation in pedigreed populations. In: Ballou, J. D., Gilpin, M., Foose, T. J. (eds), Population Management for Survival and Recovery, Columbia University Press, New York, pp. 76-111.
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Takeshi Honda, Kenji Oyama. (2019). Improvement of the Maximum Avoidance of Inbreeding by the Use of Cell Manipulation Technique in Gametogenesis. Animal and Veterinary Sciences, 7(4), 99-103. https://doi.org/10.11648/j.avs.20190704.14

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Takeshi Honda; Kenji Oyama. Improvement of the Maximum Avoidance of Inbreeding by the Use of Cell Manipulation Technique in Gametogenesis. Anim. Vet. Sci. 2019, 7(4), 99-103. doi: 10.11648/j.avs.20190704.14

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AMA Style

Takeshi Honda, Kenji Oyama. Improvement of the Maximum Avoidance of Inbreeding by the Use of Cell Manipulation Technique in Gametogenesis. Anim Vet Sci. 2019;7(4):99-103. doi: 10.11648/j.avs.20190704.14

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@article{10.11648/j.avs.20190704.14,
  author = {Takeshi Honda and Kenji Oyama},
  title = {Improvement of the Maximum Avoidance of Inbreeding by the Use of Cell Manipulation Technique in Gametogenesis},
  journal = {Animal and Veterinary Sciences},
  volume = {7},
  number = {4},
  pages = {99-103},
  doi = {10.11648/j.avs.20190704.14},
  url = {https://doi.org/10.11648/j.avs.20190704.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20190704.14},
  abstract = {Reduction of genetic drift for preservation of genetic variability is one of the primary concerns for maintenance of endangered species in captivity. For this purpose, a number of selection schemes to equalize parental contributions to the next generation have been widely accepted as a simple guideline, but genetic drift due to random segregation of heterozygote parents, so-called Mendelian sampling, has remained unavoidable. In the past, the use of cell manipulation techniques developed in a field of mammal reproductive technology has been suggested to restrict this genetic drift. However, its potential benefit has been examined only for a randomly mating population of equal sex ratio. In this study, we assumed the situation where the cell manipulation technique is applied to the population under the mating system of maximum avoidance of inbreeding (MAI), and examined its effect on the progress of inbreeding by developing a recurrence equation of panmictic indices of the population. Inbreeding coefficient was substantially suppressed at the locus site where the mean number of crossovers between the site and centromere (m) was small. Although inbreeding coefficient inflated as m increased, its effect diminished as m increased. These tendencies were observed irrespective of the size of the population.},
 year = {2019}
}

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TY  - JOUR
T1  - Improvement of the Maximum Avoidance of Inbreeding by the Use of Cell Manipulation Technique in Gametogenesis
AU  - Takeshi Honda
AU  - Kenji Oyama
Y1  - 2019/08/26
PY  - 2019
N1  - https://doi.org/10.11648/j.avs.20190704.14
DO  - 10.11648/j.avs.20190704.14
T2  - Animal and Veterinary Sciences
JF  - Animal and Veterinary Sciences
JO  - Animal and Veterinary Sciences
SP  - 99
EP  - 103
PB  - Science Publishing Group
SN  - 2328-5850
UR  - https://doi.org/10.11648/j.avs.20190704.14
AB  - Reduction of genetic drift for preservation of genetic variability is one of the primary concerns for maintenance of endangered species in captivity. For this purpose, a number of selection schemes to equalize parental contributions to the next generation have been widely accepted as a simple guideline, but genetic drift due to random segregation of heterozygote parents, so-called Mendelian sampling, has remained unavoidable. In the past, the use of cell manipulation techniques developed in a field of mammal reproductive technology has been suggested to restrict this genetic drift. However, its potential benefit has been examined only for a randomly mating population of equal sex ratio. In this study, we assumed the situation where the cell manipulation technique is applied to the population under the mating system of maximum avoidance of inbreeding (MAI), and examined its effect on the progress of inbreeding by developing a recurrence equation of panmictic indices of the population. Inbreeding coefficient was substantially suppressed at the locus site where the mean number of crossovers between the site and centromere (m) was small. Although inbreeding coefficient inflated as m increased, its effect diminished as m increased. These tendencies were observed irrespective of the size of the population.
VL  - 7
IS  - 4
ER  -

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Author Information

Takeshi Honda

Food Resources Education and Research Center, Graduate School of Agricultural Science, Kobe University, Hyogo, Japan
Kenji Oyama

Food Resources Education and Research Center, Graduate School of Agricultural Science, Kobe University, Hyogo, Japan

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APA Style

Takeshi Honda, Kenji Oyama. (2019). Improvement of the Maximum Avoidance of Inbreeding by the Use of Cell Manipulation Technique in Gametogenesis. Animal and Veterinary Sciences, 7(4), 99-103. https://doi.org/10.11648/j.avs.20190704.14

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ACS Style

Takeshi Honda; Kenji Oyama. Improvement of the Maximum Avoidance of Inbreeding by the Use of Cell Manipulation Technique in Gametogenesis. Anim. Vet. Sci. 2019, 7(4), 99-103. doi: 10.11648/j.avs.20190704.14

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AMA Style

Takeshi Honda, Kenji Oyama. Improvement of the Maximum Avoidance of Inbreeding by the Use of Cell Manipulation Technique in Gametogenesis. Anim Vet Sci. 2019;7(4):99-103. doi: 10.11648/j.avs.20190704.14

Copy | Download

@article{10.11648/j.avs.20190704.14,
  author = {Takeshi Honda and Kenji Oyama},
  title = {Improvement of the Maximum Avoidance of Inbreeding by the Use of Cell Manipulation Technique in Gametogenesis},
  journal = {Animal and Veterinary Sciences},
  volume = {7},
  number = {4},
  pages = {99-103},
  doi = {10.11648/j.avs.20190704.14},
  url = {https://doi.org/10.11648/j.avs.20190704.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20190704.14},
  abstract = {Reduction of genetic drift for preservation of genetic variability is one of the primary concerns for maintenance of endangered species in captivity. For this purpose, a number of selection schemes to equalize parental contributions to the next generation have been widely accepted as a simple guideline, but genetic drift due to random segregation of heterozygote parents, so-called Mendelian sampling, has remained unavoidable. In the past, the use of cell manipulation techniques developed in a field of mammal reproductive technology has been suggested to restrict this genetic drift. However, its potential benefit has been examined only for a randomly mating population of equal sex ratio. In this study, we assumed the situation where the cell manipulation technique is applied to the population under the mating system of maximum avoidance of inbreeding (MAI), and examined its effect on the progress of inbreeding by developing a recurrence equation of panmictic indices of the population. Inbreeding coefficient was substantially suppressed at the locus site where the mean number of crossovers between the site and centromere (m) was small. Although inbreeding coefficient inflated as m increased, its effect diminished as m increased. These tendencies were observed irrespective of the size of the population.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Improvement of the Maximum Avoidance of Inbreeding by the Use of Cell Manipulation Technique in Gametogenesis
AU  - Takeshi Honda
AU  - Kenji Oyama
Y1  - 2019/08/26
PY  - 2019
N1  - https://doi.org/10.11648/j.avs.20190704.14
DO  - 10.11648/j.avs.20190704.14
T2  - Animal and Veterinary Sciences
JF  - Animal and Veterinary Sciences
JO  - Animal and Veterinary Sciences
SP  - 99
EP  - 103
PB  - Science Publishing Group
SN  - 2328-5850
UR  - https://doi.org/10.11648/j.avs.20190704.14
AB  - Reduction of genetic drift for preservation of genetic variability is one of the primary concerns for maintenance of endangered species in captivity. For this purpose, a number of selection schemes to equalize parental contributions to the next generation have been widely accepted as a simple guideline, but genetic drift due to random segregation of heterozygote parents, so-called Mendelian sampling, has remained unavoidable. In the past, the use of cell manipulation techniques developed in a field of mammal reproductive technology has been suggested to restrict this genetic drift. However, its potential benefit has been examined only for a randomly mating population of equal sex ratio. In this study, we assumed the situation where the cell manipulation technique is applied to the population under the mating system of maximum avoidance of inbreeding (MAI), and examined its effect on the progress of inbreeding by developing a recurrence equation of panmictic indices of the population. Inbreeding coefficient was substantially suppressed at the locus site where the mean number of crossovers between the site and centromere (m) was small. Although inbreeding coefficient inflated as m increased, its effect diminished as m increased. These tendencies were observed irrespective of the size of the population.
VL  - 7
IS  - 4
ER  -

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