Highly Anticancer and Moderate Thrombolytic Property of Accacia rugata of Mimosaceae Family
Journal of Plant Sciences
Volume 8, Issue 1, February 2020, Pages: 12-16
Received: Feb. 2, 2020; Accepted: Feb. 26, 2020; Published: Apr. 7, 2020
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Bibi Humayra Khanam, Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh
Ahmed Rakib, Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh
Farhana Binta Faiz, Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh
Md. Giash Uddin, Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh
Mohammed Kamrul Hossain, Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh
Ramiz Ahmed Sultan, Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh
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Medicinal plants containing potent bioactive compound effective in treating many diseases exert different pharmacological action. This study designed to evaluate the cytotoxic and thrombolytic activity of Acacia rugata of Mimosaceae family. The cytotoxic and thrombolytic activity was evaluated by brine-shrimp lethality bioassay and in-vitro clot lysis method. Methanol, petroleum-ether, n-hexane, chloroform and dichloromethane fraction leaves (MEL, PETFL, n-HxFL, CHFL, DCMFL), methanol and n-hexane fraction of fruits (MEF, n-HxFF) and methanol fraction of bark (MEB) were used to evaluate cytotoxicity of the plant. Each extracts showed significant cytotoxic property. The LC50 values of MEL, PETFL, n-HxFL, CHFL, DCMFL, MEF, n-HxFF, MEB were observed 1.436, 0.039, 0.974, 0.626, 0.121, 0.176, 0.865, 0.081 µg/ml when compared to standard vincristine (positive control) which LC50 value was 0.049 µg/ml. In thrombolytic activity evaluation 20 mg/ml, 10 mg/ml, 5 mg/ml and 2.5 mg/ml dose of MEL showed 40.52 ± 2.91, 35.09 ± 2.71, 31.96 ± 2.02 and 24.91 ± 3.05% clot lysis respectively while 0.9% NaCl solution (negative control) and standard streptokinase (positive control) exhibited 7.41 ± 1.73% and 48.91 ± 3.52% of clot lysis. It can be assumed that different solvent extracts of A. rugata have important cytotoxic and thrombolytic activity as compared to standard compounds.
Cytotoxic, Thrombolytic, Streptokinase, Vincristine, % of Clot Lysis, Acacia rugata
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Bibi Humayra Khanam, Ahmed Rakib, Farhana Binta Faiz, Md. Giash Uddin, Mohammed Kamrul Hossain, Ramiz Ahmed Sultan, Highly Anticancer and Moderate Thrombolytic Property of Accacia rugata of Mimosaceae Family, Journal of Plant Sciences. Vol. 8, No. 1, 2020, pp. 12-16. doi: 10.11648/j.jps.20200801.12
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