Journal of Plant Sciences

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Effect of the Ethanolic Leaf Extract of Moringa oleifera on Insulin Resistance in Streptozotocin Induced Diabetic Rats

Received: 29 August 2014    Accepted: 06 October 2014    Published: 14 March 2015
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Abstract

Insulin resistance plays a central role in the pathogenesis of type 2 diabetes mellitus. Ameliorating insulin resistance helps to improve glycaemic control and hence reduce the risk of development and progression of diabetic complications. The extract of Moringa oleifera has been shown to improve hyperglycaemia, however, little is known on its effect on insulin resistance and beta-cell function. The objective of this study was to determine the effect of the ethanolic leaf extract of Moringa oleifera on insulin resistance in high-fat diet and streptozotocin induced diabetic rats. Different doses (250 and 500 mg/kg) of the ethanolic leaf extract of Moringa oleifera were administered orally for two weeks, to high-fat diet and streptozotocin induced diabetic rats, and were compared with metformin 320 mg/kg and control group (distilled water 10 ml/kg) for the effect on fasting blood glucose, serum insulin and insulin resistance (HOMA). The extract of Moringa oleifera (at doses of 250 mg/kg and 500 mg/kg) significantly lowered the fasting blood glucose at days 7 and 14 compared to controls (p = 0.0021 and p = 0.0001 respectively). There was a significant increase in serum insulin level in the control group at days 7 and 14 compared to the groups treated with the extract (250 mg/kg, 500 mg/kg) and metformin (p<0.01, p<0.02 and p<0.01 respectively). The extract at both doses and metformin (320 mg/kg) induced a significant improvement in insulin resistance (HOMA-IR) on days 7 and 14 (p < 0.0001).

DOI 10.11648/j.jps.s.2014020601.12
Published in Journal of Plant Sciences (Volume 2, Issue 6-1, December 2014)

This article belongs to the Special Issue Pharmacological and Biological Investigation of Medicinal Plants

Page(s) 5-12
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Insulin Resistance, Moringa oleifera, Diabetes Mellitus, High-Fat Diet

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Author Information
  • Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Lagos University Teaching Hospital, LUTH, Lagos, Nigeria

  • Department of Pharmacology, College of Medicine, University of Lagos (CMUL), Lagos, Nigeria

  • Department of Pharmacology, College of Medicine, University of Lagos (CMUL), Lagos, Nigeria

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    Anyanwu Anthony Chinedu., Salako Olanrewaju Alani., Adeyemi Olufunmi Olaide. (2015). Effect of the Ethanolic Leaf Extract of Moringa oleifera on Insulin Resistance in Streptozotocin Induced Diabetic Rats. Journal of Plant Sciences, 2(6-1), 5-12. https://doi.org/10.11648/j.jps.s.2014020601.12

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    Anyanwu Anthony Chinedu.; Salako Olanrewaju Alani.; Adeyemi Olufunmi Olaide. Effect of the Ethanolic Leaf Extract of Moringa oleifera on Insulin Resistance in Streptozotocin Induced Diabetic Rats. J. Plant Sci. 2015, 2(6-1), 5-12. doi: 10.11648/j.jps.s.2014020601.12

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    Anyanwu Anthony Chinedu., Salako Olanrewaju Alani., Adeyemi Olufunmi Olaide. Effect of the Ethanolic Leaf Extract of Moringa oleifera on Insulin Resistance in Streptozotocin Induced Diabetic Rats. J Plant Sci. 2015;2(6-1):5-12. doi: 10.11648/j.jps.s.2014020601.12

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  • @article{10.11648/j.jps.s.2014020601.12,
      author = {Anyanwu Anthony Chinedu. and Salako Olanrewaju Alani. and Adeyemi Olufunmi Olaide.},
      title = {Effect of the Ethanolic Leaf Extract of Moringa oleifera on Insulin Resistance in Streptozotocin Induced Diabetic Rats},
      journal = {Journal of Plant Sciences},
      volume = {2},
      number = {6-1},
      pages = {5-12},
      doi = {10.11648/j.jps.s.2014020601.12},
      url = {https://doi.org/10.11648/j.jps.s.2014020601.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jps.s.2014020601.12},
      abstract = {Insulin resistance plays a central role in the pathogenesis of type 2 diabetes mellitus. Ameliorating insulin resistance helps to improve glycaemic control and hence reduce the risk of development and progression of diabetic complications. The extract of Moringa oleifera has been shown to improve hyperglycaemia, however, little is known on its effect on insulin resistance and beta-cell function. The objective of this study was to determine the effect of  the ethanolic leaf extract of Moringa oleifera on insulin resistance in high-fat diet and streptozotocin induced diabetic rats. Different doses (250 and 500 mg/kg) of the ethanolic leaf extract of Moringa oleifera were administered orally for two weeks, to high-fat diet and streptozotocin induced diabetic rats, and were compared with metformin 320 mg/kg and control group (distilled water 10 ml/kg) for the effect on fasting blood glucose, serum insulin and insulin resistance (HOMA). The extract of Moringa oleifera (at doses of 250 mg/kg and 500 mg/kg) significantly lowered the fasting blood glucose at days 7 and 14 compared to controls (p = 0.0021 and p = 0.0001 respectively). There was a significant increase in serum insulin level in the control group at days 7 and 14 compared to the groups treated with the extract (250 mg/kg, 500 mg/kg) and metformin (p<0.01, p<0.02 and p<0.01 respectively). The extract at both doses and metformin (320 mg/kg) induced a significant improvement in insulin resistance (HOMA-IR) on days 7 and 14 (p < 0.0001).},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Effect of the Ethanolic Leaf Extract of Moringa oleifera on Insulin Resistance in Streptozotocin Induced Diabetic Rats
    AU  - Anyanwu Anthony Chinedu.
    AU  - Salako Olanrewaju Alani.
    AU  - Adeyemi Olufunmi Olaide.
    Y1  - 2015/03/14
    PY  - 2015
    N1  - https://doi.org/10.11648/j.jps.s.2014020601.12
    DO  - 10.11648/j.jps.s.2014020601.12
    T2  - Journal of Plant Sciences
    JF  - Journal of Plant Sciences
    JO  - Journal of Plant Sciences
    SP  - 5
    EP  - 12
    PB  - Science Publishing Group
    SN  - 2331-0731
    UR  - https://doi.org/10.11648/j.jps.s.2014020601.12
    AB  - Insulin resistance plays a central role in the pathogenesis of type 2 diabetes mellitus. Ameliorating insulin resistance helps to improve glycaemic control and hence reduce the risk of development and progression of diabetic complications. The extract of Moringa oleifera has been shown to improve hyperglycaemia, however, little is known on its effect on insulin resistance and beta-cell function. The objective of this study was to determine the effect of  the ethanolic leaf extract of Moringa oleifera on insulin resistance in high-fat diet and streptozotocin induced diabetic rats. Different doses (250 and 500 mg/kg) of the ethanolic leaf extract of Moringa oleifera were administered orally for two weeks, to high-fat diet and streptozotocin induced diabetic rats, and were compared with metformin 320 mg/kg and control group (distilled water 10 ml/kg) for the effect on fasting blood glucose, serum insulin and insulin resistance (HOMA). The extract of Moringa oleifera (at doses of 250 mg/kg and 500 mg/kg) significantly lowered the fasting blood glucose at days 7 and 14 compared to controls (p = 0.0021 and p = 0.0001 respectively). There was a significant increase in serum insulin level in the control group at days 7 and 14 compared to the groups treated with the extract (250 mg/kg, 500 mg/kg) and metformin (p<0.01, p<0.02 and p<0.01 respectively). The extract at both doses and metformin (320 mg/kg) induced a significant improvement in insulin resistance (HOMA-IR) on days 7 and 14 (p < 0.0001).
    VL  - 2
    IS  - 6-1
    ER  - 

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