Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine

Diallo M. S. T.; Baldé M. A.; Camara A.; Traoré M. S.; Bah M. L.; Diallo A. S.; Camara A. K.; Laurent S.; Roch A.; Muller R. N.; Maes L.; Pieters L.; Baldé A. M.

doi:doi:10.11648/j.jps.s.2015030102.18

Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine

Diallo M. S. T., Baldé M. A., Camara A., Traoré M. S., Bah M. L., Diallo A. S., Camara A. K., Laurent S., Roch A., Muller R. N., Maes L., Pieters L., Baldé A. M.

Published in Journal of Plant Sciences (Volume 3, Issue 1-2)

Received: 21 November 2014 Accepted: 24 November 2014 Published: 27 December 2014

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Abstract

From an ethnomedical survey conducted in Conakry and Dubreka (Guinea), 12 traditional healers and 10 herbalists were interviewed. Their knowledge and experience along with the traditional uses of Margaritaria discoidea (euphorbiaceae) were recorded. The fractionation and purification of the leaf extract led to the isolation of a series of securinane-type alkaloids including the known ent-Phyllanthidine, 14,15-dihydroallosecurinine-15-β-ol, securinine, securinol, and viroallosecurinine. Their structures were elucidated on the basis of 1H and 13C-NMR data and comparison with published spectra. The biological activities of the methanol and chloroform leaf extracts along with the alkaloids Y were evaluated against Escherichia coli, Staphylococcus aureus, Candida albicans, Mycobacterium chelonae, the protozoa Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei brucei,and Trypanosoma cruzi and/or HIV1 and 2. Although weak to moderate, these biological findings support partly the wide traditional use of Margaritaria discoidea.

Published in	Journal of Plant Sciences (Volume 3, Issue 1-2) This article belongs to the Special Issue Ethnopharmacological Investigation of Medicinal Plants
DOI	10.11648/j.jps.s.2015030102.18
Page(s)	40-46
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Ethnomedicine, Securinane-Type Alkaloids, Antimicrobial, Antiprotozoal

References

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Diallo M. S. T., Baldé M. A., Camara A., Traoré M. S., Bah M. L., et al. (2014). Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine. Journal of Plant Sciences, 3(1-2), 40-46. https://doi.org/10.11648/j.jps.s.2015030102.18

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ACS Style

Diallo M. S. T.; Baldé M. A.; Camara A.; Traoré M. S.; Bah M. L., et al. Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine. J. Plant Sci. 2014, 3(1-2), 40-46. doi: 10.11648/j.jps.s.2015030102.18

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AMA Style

Diallo M. S. T., Baldé M. A., Camara A., Traoré M. S., Bah M. L., et al. Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine. J Plant Sci. 2014;3(1-2):40-46. doi: 10.11648/j.jps.s.2015030102.18

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@article{10.11648/j.jps.s.2015030102.18,
  author = {Diallo M. S. T. and Baldé M. A. and Camara A. and Traoré M. S. and Bah M. L. and Diallo A. S. and Camara A. K. and Laurent S. and Roch A. and Muller R. N. and Maes L. and Pieters L. and Baldé A. M.},
  title = {Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine},
  journal = {Journal of Plant Sciences},
  volume = {3},
  number = {1-2},
  pages = {40-46},
  doi = {10.11648/j.jps.s.2015030102.18},
  url = {https://doi.org/10.11648/j.jps.s.2015030102.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jps.s.2015030102.18},
  abstract = {From an ethnomedical survey conducted in Conakry and Dubreka (Guinea), 12 traditional healers and 10 herbalists were interviewed. Their knowledge and experience along with the traditional uses of Margaritaria discoidea (euphorbiaceae) were recorded. The fractionation and purification of the leaf extract led to the isolation of a series of securinane-type alkaloids including the known ent-Phyllanthidine, 14,15-dihydroallosecurinine-15-β-ol, securinine, securinol, and viroallosecurinine. Their structures were elucidated on the basis of 1H and 13C-NMR data and comparison with published spectra. The biological activities of the methanol and chloroform leaf extracts along with the alkaloids Y were evaluated against Escherichia coli, Staphylococcus aureus, Candida albicans, Mycobacterium chelonae, the protozoa Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei brucei,and Trypanosoma cruzi and/or HIV1 and 2. Although weak to moderate, these biological findings support partly the wide traditional use of Margaritaria discoidea.},
 year = {2014}
}

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TY  - JOUR
T1  - Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine
AU  - Diallo M. S. T.
AU  - Baldé M. A.
AU  - Camara A.
AU  - Traoré M. S.
AU  - Bah M. L.
AU  - Diallo A. S.
AU  - Camara A. K.
AU  - Laurent S.
AU  - Roch A.
AU  - Muller R. N.
AU  - Maes L.
AU  - Pieters L.
AU  - Baldé A. M.
Y1  - 2014/12/27
PY  - 2014
N1  - https://doi.org/10.11648/j.jps.s.2015030102.18
DO  - 10.11648/j.jps.s.2015030102.18
T2  - Journal of Plant Sciences
JF  - Journal of Plant Sciences
JO  - Journal of Plant Sciences
SP  - 40
EP  - 46
PB  - Science Publishing Group
SN  - 2331-0731
UR  - https://doi.org/10.11648/j.jps.s.2015030102.18
AB  - From an ethnomedical survey conducted in Conakry and Dubreka (Guinea), 12 traditional healers and 10 herbalists were interviewed. Their knowledge and experience along with the traditional uses of Margaritaria discoidea (euphorbiaceae) were recorded. The fractionation and purification of the leaf extract led to the isolation of a series of securinane-type alkaloids including the known ent-Phyllanthidine, 14,15-dihydroallosecurinine-15-β-ol, securinine, securinol, and viroallosecurinine. Their structures were elucidated on the basis of 1H and 13C-NMR data and comparison with published spectra. The biological activities of the methanol and chloroform leaf extracts along with the alkaloids Y were evaluated against Escherichia coli, Staphylococcus aureus, Candida albicans, Mycobacterium chelonae, the protozoa Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei brucei,and Trypanosoma cruzi and/or HIV1 and 2. Although weak to moderate, these biological findings support partly the wide traditional use of Margaritaria discoidea.
VL  - 3
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Author Information

Diallo M. S. T.

Centre de Recherche et de Valorisation des Plantes Médicinales (CRVPM) de Dubréka, Dubréka, Guinée
Baldé M. A.

Centre de Recherche et de Valorisation des Plantes Médicinales (CRVPM) de Dubréka, Dubréka, Guinée; Département de Pharmacie, Faculté de Médecine-Pharmacie-Odontostomatologie, Université Gamal Abdel Nasser de Conakry, Conakry, Guinée
Camara A.

Centre de Recherche et de Valorisation des Plantes Médicinales (CRVPM) de Dubréka, Dubréka, Guinée
Traoré M. S.

Centre de Recherche et de Valorisation des Plantes Médicinales (CRVPM) de Dubréka, Dubréka, Guinée; Département de Pharmacie, Faculté de Médecine-Pharmacie-Odontostomatologie, Université Gamal Abdel Nasser de Conakry, Conakry, Guinée
Bah M. L.

Centre de Recherche et de Valorisation des Plantes Médicinales (CRVPM) de Dubréka, Dubréka, Guinée
Diallo A. S.

Centre de Recherche et de Valorisation des Plantes Médicinales (CRVPM) de Dubréka, Dubréka, Guinée
Camara A. K.

Département de Pharmacie, Faculté de Médecine-Pharmacie-Odontostomatologie, Université Gamal Abdel Nasser de Conakry, Conakry, Guinée
Laurent S.

Service de Chimie Générale, Organique et Biomédicale; Laboratoire de RMN et d’Imagerie Moléculaire, Université de Mons, Mons, Belgique
Roch A.

Service de Chimie Générale, Organique et Biomédicale; Laboratoire de RMN et d’Imagerie Moléculaire, Université de Mons, Mons, Belgique
Muller R. N.

Service de Chimie Générale, Organique et Biomédicale; Laboratoire de RMN et d’Imagerie Moléculaire, Université de Mons, Mons, Belgique
Maes L.

Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
Pieters L.

Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium
Baldé A. M.

Centre de Recherche et de Valorisation des Plantes Médicinales (CRVPM) de Dubréka, Dubréka, Guinée; Département de Pharmacie, Faculté de Médecine-Pharmacie-Odontostomatologie, Université Gamal Abdel Nasser de Conakry, Conakry, Guinée

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Diallo M. S. T., Baldé M. A., Camara A., Traoré M. S., Bah M. L., et al. (2014). Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine. Journal of Plant Sciences, 3(1-2), 40-46. https://doi.org/10.11648/j.jps.s.2015030102.18

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ACS Style

Diallo M. S. T.; Baldé M. A.; Camara A.; Traoré M. S.; Bah M. L., et al. Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine. J. Plant Sci. 2014, 3(1-2), 40-46. doi: 10.11648/j.jps.s.2015030102.18

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AMA Style

Diallo M. S. T., Baldé M. A., Camara A., Traoré M. S., Bah M. L., et al. Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine. J Plant Sci. 2014;3(1-2):40-46. doi: 10.11648/j.jps.s.2015030102.18

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@article{10.11648/j.jps.s.2015030102.18,
  author = {Diallo M. S. T. and Baldé M. A. and Camara A. and Traoré M. S. and Bah M. L. and Diallo A. S. and Camara A. K. and Laurent S. and Roch A. and Muller R. N. and Maes L. and Pieters L. and Baldé A. M.},
  title = {Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine},
  journal = {Journal of Plant Sciences},
  volume = {3},
  number = {1-2},
  pages = {40-46},
  doi = {10.11648/j.jps.s.2015030102.18},
  url = {https://doi.org/10.11648/j.jps.s.2015030102.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jps.s.2015030102.18},
  abstract = {From an ethnomedical survey conducted in Conakry and Dubreka (Guinea), 12 traditional healers and 10 herbalists were interviewed. Their knowledge and experience along with the traditional uses of Margaritaria discoidea (euphorbiaceae) were recorded. The fractionation and purification of the leaf extract led to the isolation of a series of securinane-type alkaloids including the known ent-Phyllanthidine, 14,15-dihydroallosecurinine-15-β-ol, securinine, securinol, and viroallosecurinine. Their structures were elucidated on the basis of 1H and 13C-NMR data and comparison with published spectra. The biological activities of the methanol and chloroform leaf extracts along with the alkaloids Y were evaluated against Escherichia coli, Staphylococcus aureus, Candida albicans, Mycobacterium chelonae, the protozoa Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei brucei,and Trypanosoma cruzi and/or HIV1 and 2. Although weak to moderate, these biological findings support partly the wide traditional use of Margaritaria discoidea.},
 year = {2014}
}

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TY  - JOUR
T1  - Ethnomedical, Phytochemical and Biological Investigations of Margaritaria discoidea (Baill.) Webster, a Plant Species Widely Used in Guinean Traditional Medicine
AU  - Diallo M. S. T.
AU  - Baldé M. A.
AU  - Camara A.
AU  - Traoré M. S.
AU  - Bah M. L.
AU  - Diallo A. S.
AU  - Camara A. K.
AU  - Laurent S.
AU  - Roch A.
AU  - Muller R. N.
AU  - Maes L.
AU  - Pieters L.
AU  - Baldé A. M.
Y1  - 2014/12/27
PY  - 2014
N1  - https://doi.org/10.11648/j.jps.s.2015030102.18
DO  - 10.11648/j.jps.s.2015030102.18
T2  - Journal of Plant Sciences
JF  - Journal of Plant Sciences
JO  - Journal of Plant Sciences
SP  - 40
EP  - 46
PB  - Science Publishing Group
SN  - 2331-0731
UR  - https://doi.org/10.11648/j.jps.s.2015030102.18
AB  - From an ethnomedical survey conducted in Conakry and Dubreka (Guinea), 12 traditional healers and 10 herbalists were interviewed. Their knowledge and experience along with the traditional uses of Margaritaria discoidea (euphorbiaceae) were recorded. The fractionation and purification of the leaf extract led to the isolation of a series of securinane-type alkaloids including the known ent-Phyllanthidine, 14,15-dihydroallosecurinine-15-β-ol, securinine, securinol, and viroallosecurinine. Their structures were elucidated on the basis of 1H and 13C-NMR data and comparison with published spectra. The biological activities of the methanol and chloroform leaf extracts along with the alkaloids Y were evaluated against Escherichia coli, Staphylococcus aureus, Candida albicans, Mycobacterium chelonae, the protozoa Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei brucei,and Trypanosoma cruzi and/or HIV1 and 2. Although weak to moderate, these biological findings support partly the wide traditional use of Margaritaria discoidea.
VL  - 3
IS  - 1-2
ER  -

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