Toxicological Study of the Seed Extracts from <i>Dodonaea madagascariensis</i> Radlk (Sapindaceae), a Malagasy Medicinal Plant

Mihajasoa Stella Razanatseheno; Clara Fredeline Rajemiarimoelisoa; Zoarilala Rinah Razafindrakoto; David Ramanitrahasimbola; Danielle Aurore Doll Rakoto; Hanitra Ranjana Randrianarivo; Victor Louis Jeannoda

doi:doi:10.11648/j.jps.20150306.13

Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant

Mihajasoa Stella Razanatseheno, Clara Fredeline Rajemiarimoelisoa, Zoarilala Rinah Razafindrakoto, David Ramanitrahasimbola, Danielle Aurore Doll Rakoto, Hanitra Ranjana Randrianarivo, Victor Louis Jeannoda

Published in Journal of Plant Sciences (Volume 3, Issue 6)

Received: 26 October 2015 Accepted: 4 November 2015 Published: 19 November 2015

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Abstract

This work was designed to study the seed toxicity of Dodonaea madagascariensis Radlk. (Sapindaceae), an endemic plant to Madagascar with multiple medicinal uses. Using different experimental models of animals, seed methanolic extract of D. madagascariensis (SMED) was found to be toxic to mice (LD50 of 36.12 mg/ kg by intraperitoneal route), chicks (Gallus gallus domesticus), juvenile fishes (Cyprinus carpio) (LC50 of 4.33 µg/mL) and frog tadpoles (Ptychadena mascareniensis) (LC50 of 5.41 µg/mL). Toxicity was ascribed to saponin group only. In mice, SMED developed different symptoms when administered by intraperitoneal, subcutaneous and oral routes. Trailing of the posterior limbs, low body posture, tremors, ataxia, abdominal breathing and at high dose, diarrhea were the most common occurring symptoms. In acute and subchronic administrations, SMED caused damages in the liver, kidneys, lungs, small and large intestines while brain, heart and stomach were not affected. No significant changes on serum concentration of ASAT, ALAT and creatinine were observed after oral subchronic exposure (30 days) to SMED at 12.71 mg/kg. SMED exerted a positive inotropic effect on isolated guinea pig atria at 12.5 µg/mL and had a hemolytic activity. In the light of these preliminary results, the toxicity of D. madagascariensis seeds could be used in the control of harmful cold blooded animals.

Published in	Journal of Plant Sciences (Volume 3, Issue 6)
DOI	10.11648/j.jps.20150306.13
Page(s)	303-309
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Dodonaea madagascariensis, Seed Methanolic Extract, Saponins, Toxicity, Histopathological Lesions, Biochemical Parameters

References

[1]	V. L. R. Jeannoda, J. Valisolalao, E. E. Creppy, and G. Dirheimer. Identification of the Toxic Principle of Cnestis glabra (Connaraceae) as Methionine sulfoximine. Phytochemistry 24 (1985) 854-855.
[2]	L. Rakotobe, Lengo Mambu, A. Deville, L. Dubost, V. Jeannoda, D. Rakoto and B. Bodo. Clerodane and 19-norclerodane Diterpenoids from the tubers of Dioscorea antaly. Phytochemistry 71 (2010) 1007-1013.
[3]	V. Razafintsalama, M. Girardot, R. Randrianarivo, D. Rakoto, S. Sarter, T. Petit, S. Ralambonirina, A. Deville, P. Grellier, V. Jeannoda and L. Mambu. Dilobenol A-G, Diprenylated Dihydroflavonols from Leaves of Dilobeia thouarsii. Eur. J. Chem. 87 (2013) 1936-1949.
[4]	D. A. D. Rakoto, C. Rajemiarimoelisoa, R. Randrianarivo, D. Ramamonjison, C. Raheriniaina, N. Raharisoa and V. Jeannoda. Antimicrobial Activity of Some Endemic Species of Albizia (Fabaceae) from Madagascar, Asian Biotechnology and Development Review, 13 (2011) 53-60.
[5]	D. A. D. Rakoto, R. Randrianarivo, M. El-Yachouroutui, A. A. Arisoa, N. Raharisoa, N. Rakotondrasoa, P. Raoniharisoa and V. Jeannoda. Effects of extracts from Albizia (Fabaceae) endemic species of Madagascar on vegetable seedling development, J. Chem. Chem. Eng. 6 (2012) 313-322.
[6]	L. Randriamampianina, A. Offroy, L. Mambu, H. R. Randrianarivo, D. Rakoto, V. Jeannoda, C. Djediat, S. Puiseux Dao and M. Edery, Marked toxicity of Albizia bernieri extracts on embryo-larval development in the Medaka fish (Oryzias latipes), Toxicon 64 (2013) 29-35.
[7]	H. R. Randrianarivo, A. R. Razafindrakoto, H. C. Ratsimanohatra, L. J. Randriamampianina, C. F. Rajemiarimoelisoa, L. Ramamonjisoa, D. Ramanitrahasimbola, D. A. D. Rakoto, and V. L. Jeannoda. Toxic effects of seed methanolic extracts of endemic Albizia species (Fabaceae) from Madagascar on animals, Journal of life Sciences, 8 (8) (2014) 679-689.
[8]	H. R. Randrianarivo, H. C. Ratsimanohatra, A. R. Razafindrakoto, C. F. Rajemiarimoelisoa, L. J. Randriamampianina, L. Ramamonjisoa, D. A. D. Rakoto and V. L. Jeannoda. Phytotoxic property of seed methanolic extracts from Albizia (Fabaceae) endemic species of Madagascar. Journal of Plant Sciences 2 (6) (2014) 256-265.
[9]	C. F. Rajemiarimoelisoa, D. A. D. Rakoto, H. R. Randrianarivo and V. L. Jeannoda. Purification and toxicity study of a saponin from seeds of Albizia odorata, a Fabaceae from Madagascar, Journal of plant sciences, 3 (5) (2015) 264-271.
[10]	C. F. Rajemiarimoelisoa, C. B. L. Pellissierb, M. Peuchmaurb, H. R. Randrianarivo, D. A. D. Rakoto, V. L. Jeannoda and A. Boumendjel. Isolation of β-carbolines from pods of Albizia polyphylla. Natural Product Research (in press).
[11]	M. P. Choux. Les Sapindaceae de Madagascar. Tananarive: Imprimerie Moderne de l’Emyrne, (Mémoire de l’Académie Malgache, Fascicule IV) (1927) 118 p.
[12]	R. Capuron. Révision des SAPINDACEES de Madagascar et des Comores. Paris: Mémoires du Muséum National d’Histoire Naturelle, (Série B, Tome XIX), (1969) 189 p.
[13]	G. E. Schatz. Flore générique des arbres de Madagascar. Grande Bretagne: Royal Botanic Gardens, Kew & Missouri Botanical Garden, (2001) 503 p.
[14]	J. Meenu, S. Sunil and K. Manoj Evaluation of antihyperglycemic activity of Dodonaea viscosa leaves in normal and STZ-diabetic rats. Int J Pharm Pharmaceut Sci, 3 (2011) 69-74.
[15]	S. Venkatesh, Y. S. R. Reddy, M. Ramesh, M. M. Swamy, N. Mahadevan and B. Suresh. Pharmacognostical studies on Dodonaea viscosa Leaves. Afr J Pharm Pharmacol. 2 (2008) 83-88.
[16]	N. Shalaby, H. Abd-Alla, M. Hamed, S. Al-Ghamdi, S. Jambi. Flavones composition and therapeutic potential of Dodonaea viscosa against liver fibrosis. International journal of phytomedecine, 4 (1) (2012) 27-39.
[17]	M. Khurram, A. Hameed, M. U. Amin, A. Gul, N. Ullah, M. Hassan, A. Qayum, K. A. Chishti and W. Manzoor. Phytochemical screening and in vitro evaluation of anticandidal activity of Dodonaea viscosa (L.) Jaeq. (Sapindaceae. African Journal of Pharmacy and Pharmacology, 5 (11) (2011) 1422-1426.
[18]	.M. Khurram, A. Hameed, M. U. Amin, A. Gul, N. Ullah, M. Hassan, A. Qayum, K. A. Chishti and W. Manzoor. Phytochemical screening and in vitro evaluation of anticandidal activity of Dodonaea viscosa (L.) Jaeq. (Sapindaceae. African Journal of Pharmacy and Pharmacology, 5 (11) (2011) 1422-1426.
[19]	D. O. Salinas-Sanchez, M. Herrera-Ruiz, S. Perez, Jimenez- E. Ferrer and A. Zamilpa. Anti-inflammatory activity of hautriwaic acid isolated from Dodonaea viscosa leaves. Molecules, 17 (4) (2012) 4292-4299.
[20]	R. M. M. Necchi, C. Ercolani, S. L. Dalmora and M. P. Manfron. Antiinflammatory activity and concentrations of polyphenols and flavonoids in the ethanolic extract of Dodonaea viscosa (Sapindaceae), Saúde (Santa Maria), 38 (1), (2012) 113120.
[21]	N. M. Khalila, J. S. Sperottob and M. P. Manfron. Antiinflammatory activity and acute toxicity of Dodonaea viscosa. Fitoterapia,77 (6) (2006) 478–480.
[22]	V. P. Veerapur, K. R. Prabhakar, V. K. Parihar, P. Bansal, K. K. Srinivasan, K. I. Priyadarsini and M. K. Unnikrishnan: Antidiabetic, hypolipidaemic and antioxidant activity of Dodonaea viscosa aerial parts in streptozotocin- induced diabetic rats. Int J Phytomed 2 (2010) 59–70.
[23]	A. J. Pirzada, W. Shaikh, K. Usmanghani and Ejaz Mohiuddin. Antifungal activity of Dodonaea viscosa jacq extract on pathogenic fungi isolated from super ficial skin infection. Sci., 23 (3), (2010) 337-340.
[24]	M. Berhan, M. Eyasu and U. Kelbessa. In vivo Antimalarial activity of Dodonaea angustifolia seed extracts against Plasmodium Berghei in mice model. CNCS, Mekelle University 4 (1) (2012) 47-63.
[25]	F. Trotin, L. Bezanger-Beauquesne, M. Pinkas and A. Robelet. Recherche sur deux plantes de la médecine populaire malgache: Cussonia bojeri Seem. Araliacées, Dodonaea madagascariensis Radlk., SAPINDACEAE. Annales pharmaceutiques française, 30 (7-8) (1972) 555-560.
[26]	J-M. Samyn. Plantes utiles des hautes terres de Madagascar (1ère édition). Madagascar: Imprimerie Graphoprint, (1999) p81.
[27]	F. Trotin, M. Pinkas and L. Bezanger-Beauquesne. Sur les hétérosides flavoniques du Dodonaea madagascariensis Radlk. (SAPINDACEES). Compte rendu hebdomadaire des séances de l’Académie des Sciences (Série D, sciences naturelles), 271 (6) (1970) 607-610.
[28]	E. H. S. Fong, M. Tin-Wa, N. R. Farnsworth and R. H. Dobberstein. Phytochemical screening methods. Rev. Department of pharmacognosy and pharmacology, College of pharmacy, University of Illinois (1977).
[29]	G. B. Marini-Bettolo, S. Nicoletti and M. Patami, Plant screening by chemical and chromatographic procedure under field conditions, J. Chromatogr. 218 (1981) 113-217.
[30]	S. L. Deore, S. S. Khadabadi, K. P. Chittam, P. G. Bhujade, T. P. Wane, Y. R. Nagpurkar, P. D. Chanekar and R. G. Jain. Properties and pharmacological applications of saponins. Pharmacologyonline 2 (2009) 61-84.
[31]	N’dia Kouadio Frédéric, Bléyéré Nahounou Mathieu, Kouakou Kouakou Léandre, Abo Kouakou Jean Claude, Yapo Angoué Paul and Ehilé Ehouan Etienne. Acute Toxicity in Mice and Effects of a Butanol Extract from the Leaves of Blighia Unijugata Bak. (Sapindaceae) on Electrocardiogram of Rabbits. Sch. Acad. J. Pharm., 2 (6) (2013) 429-435.
[32]	L. D. Ior, M. O. Uguru, P. N. Olotu, T. L. Ohemu and A. Ukpe. Evaluation of analgesic and anti-inflammatory activities and phytochemical screening of the leaves extract of Paullinia pinnata (Sapindaceae) J. Chem. Pharm. Res., 3 (4) (2011) 351-356.

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Mihajasoa Stella Razanatseheno, Clara Fredeline Rajemiarimoelisoa, Zoarilala Rinah Razafindrakoto, David Ramanitrahasimbola, Danielle Aurore Doll Rakoto, et al. (2015). Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant. Journal of Plant Sciences, 3(6), 303-309. https://doi.org/10.11648/j.jps.20150306.13

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ACS Style

Mihajasoa Stella Razanatseheno; Clara Fredeline Rajemiarimoelisoa; Zoarilala Rinah Razafindrakoto; David Ramanitrahasimbola; Danielle Aurore Doll Rakoto, et al. Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant. J. Plant Sci. 2015, 3(6), 303-309. doi: 10.11648/j.jps.20150306.13

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AMA Style

Mihajasoa Stella Razanatseheno, Clara Fredeline Rajemiarimoelisoa, Zoarilala Rinah Razafindrakoto, David Ramanitrahasimbola, Danielle Aurore Doll Rakoto, et al. Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant. J Plant Sci. 2015;3(6):303-309. doi: 10.11648/j.jps.20150306.13

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@article{10.11648/j.jps.20150306.13,
  author = {Mihajasoa Stella Razanatseheno and Clara Fredeline Rajemiarimoelisoa and Zoarilala Rinah Razafindrakoto and David Ramanitrahasimbola and Danielle Aurore Doll Rakoto and Hanitra Ranjana Randrianarivo and Victor Louis Jeannoda},
  title = {Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant},
  journal = {Journal of Plant Sciences},
  volume = {3},
  number = {6},
  pages = {303-309},
  doi = {10.11648/j.jps.20150306.13},
  url = {https://doi.org/10.11648/j.jps.20150306.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jps.20150306.13},
  abstract = {This work was designed to study the seed toxicity of Dodonaea madagascariensis Radlk. (Sapindaceae), an endemic plant to Madagascar with multiple medicinal uses. Using different experimental models of animals, seed methanolic extract of D. madagascariensis (SMED) was found to be toxic to mice (LD50 of 36.12 mg/ kg by intraperitoneal route), chicks (Gallus gallus domesticus), juvenile fishes (Cyprinus carpio) (LC50 of 4.33 µg/mL) and frog tadpoles (Ptychadena mascareniensis) (LC50 of 5.41 µg/mL). Toxicity was ascribed to saponin group only. In mice, SMED developed different symptoms when administered by intraperitoneal, subcutaneous and oral routes. Trailing of the posterior limbs, low body posture, tremors, ataxia, abdominal breathing and at high dose, diarrhea were the most common occurring symptoms. In acute and subchronic administrations, SMED caused damages in the liver, kidneys, lungs, small and large intestines while brain, heart and stomach were not affected. No significant changes on serum concentration of ASAT, ALAT and creatinine were observed after oral subchronic exposure (30 days) to SMED at 12.71 mg/kg. SMED exerted a positive inotropic effect on isolated guinea pig atria at 12.5 µg/mL and had a hemolytic activity. In the light of these preliminary results, the toxicity of D. madagascariensis seeds could be used in the control of harmful cold blooded animals.},
 year = {2015}
}

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TY - JOUR
T1 - Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant
AU - Mihajasoa Stella Razanatseheno
AU - Clara Fredeline Rajemiarimoelisoa
AU - Zoarilala Rinah Razafindrakoto
AU - David Ramanitrahasimbola
AU - Danielle Aurore Doll Rakoto
AU - Hanitra Ranjana Randrianarivo
AU - Victor Louis Jeannoda
Y1 - 2015/11/19
PY - 2015
N1 - https://doi.org/10.11648/j.jps.20150306.13
DO - 10.11648/j.jps.20150306.13
T2 - Journal of Plant Sciences
JF - Journal of Plant Sciences
JO - Journal of Plant Sciences
SP - 303
EP - 309
PB - Science Publishing Group
SN - 2331-0731
UR - https://doi.org/10.11648/j.jps.20150306.13
AB - This work was designed to study the seed toxicity of Dodonaea madagascariensis Radlk. (Sapindaceae), an endemic plant to Madagascar with multiple medicinal uses. Using different experimental models of animals, seed methanolic extract of D. madagascariensis (SMED) was found to be toxic to mice (LD50 of 36.12 mg/ kg by intraperitoneal route), chicks (Gallus gallus domesticus), juvenile fishes (Cyprinus carpio) (LC50 of 4.33 µg/mL) and frog tadpoles (Ptychadena mascareniensis) (LC50 of 5.41 µg/mL). Toxicity was ascribed to saponin group only. In mice, SMED developed different symptoms when administered by intraperitoneal, subcutaneous and oral routes. Trailing of the posterior limbs, low body posture, tremors, ataxia, abdominal breathing and at high dose, diarrhea were the most common occurring symptoms. In acute and subchronic administrations, SMED caused damages in the liver, kidneys, lungs, small and large intestines while brain, heart and stomach were not affected. No significant changes on serum concentration of ASAT, ALAT and creatinine were observed after oral subchronic exposure (30 days) to SMED at 12.71 mg/kg. SMED exerted a positive inotropic effect on isolated guinea pig atria at 12.5 µg/mL and had a hemolytic activity. In the light of these preliminary results, the toxicity of D. madagascariensis seeds could be used in the control of harmful cold blooded animals.
VL - 3
IS - 6
ER -

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Author Information

Mihajasoa Stella Razanatseheno

Laboratory of Applied Biochemistry to Medical Sciences, Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, Antananarivo, Madagascar
Clara Fredeline Rajemiarimoelisoa

Department of Pharmacy, Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar
Zoarilala Rinah Razafindrakoto

Malagasy Institute for Applied Research (IMRA), Antananarivo, Madagascar
David Ramanitrahasimbola

Department of Pharmacy, Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar
Danielle Aurore Doll Rakoto

Laboratory of Applied Biochemistry to Medical Sciences, Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, Antananarivo, Madagascar
Hanitra Ranjana Randrianarivo

Laboratory of Applied Biochemistry to Medical Sciences, Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, Antananarivo, Madagascar
Victor Louis Jeannoda

Laboratory of Applied Biochemistry to Medical Sciences, Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, Antananarivo, Madagascar

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APA Style

Mihajasoa Stella Razanatseheno, Clara Fredeline Rajemiarimoelisoa, Zoarilala Rinah Razafindrakoto, David Ramanitrahasimbola, Danielle Aurore Doll Rakoto, et al. (2015). Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant. Journal of Plant Sciences, 3(6), 303-309. https://doi.org/10.11648/j.jps.20150306.13

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ACS Style

Mihajasoa Stella Razanatseheno; Clara Fredeline Rajemiarimoelisoa; Zoarilala Rinah Razafindrakoto; David Ramanitrahasimbola; Danielle Aurore Doll Rakoto, et al. Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant. J. Plant Sci. 2015, 3(6), 303-309. doi: 10.11648/j.jps.20150306.13

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AMA Style

Mihajasoa Stella Razanatseheno, Clara Fredeline Rajemiarimoelisoa, Zoarilala Rinah Razafindrakoto, David Ramanitrahasimbola, Danielle Aurore Doll Rakoto, et al. Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant. J Plant Sci. 2015;3(6):303-309. doi: 10.11648/j.jps.20150306.13

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@article{10.11648/j.jps.20150306.13,
  author = {Mihajasoa Stella Razanatseheno and Clara Fredeline Rajemiarimoelisoa and Zoarilala Rinah Razafindrakoto and David Ramanitrahasimbola and Danielle Aurore Doll Rakoto and Hanitra Ranjana Randrianarivo and Victor Louis Jeannoda},
  title = {Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant},
  journal = {Journal of Plant Sciences},
  volume = {3},
  number = {6},
  pages = {303-309},
  doi = {10.11648/j.jps.20150306.13},
  url = {https://doi.org/10.11648/j.jps.20150306.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jps.20150306.13},
  abstract = {This work was designed to study the seed toxicity of Dodonaea madagascariensis Radlk. (Sapindaceae), an endemic plant to Madagascar with multiple medicinal uses. Using different experimental models of animals, seed methanolic extract of D. madagascariensis (SMED) was found to be toxic to mice (LD50 of 36.12 mg/ kg by intraperitoneal route), chicks (Gallus gallus domesticus), juvenile fishes (Cyprinus carpio) (LC50 of 4.33 µg/mL) and frog tadpoles (Ptychadena mascareniensis) (LC50 of 5.41 µg/mL). Toxicity was ascribed to saponin group only. In mice, SMED developed different symptoms when administered by intraperitoneal, subcutaneous and oral routes. Trailing of the posterior limbs, low body posture, tremors, ataxia, abdominal breathing and at high dose, diarrhea were the most common occurring symptoms. In acute and subchronic administrations, SMED caused damages in the liver, kidneys, lungs, small and large intestines while brain, heart and stomach were not affected. No significant changes on serum concentration of ASAT, ALAT and creatinine were observed after oral subchronic exposure (30 days) to SMED at 12.71 mg/kg. SMED exerted a positive inotropic effect on isolated guinea pig atria at 12.5 µg/mL and had a hemolytic activity. In the light of these preliminary results, the toxicity of D. madagascariensis seeds could be used in the control of harmful cold blooded animals.},
 year = {2015}
}

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