Characterization of Synthesized NANO-encapsulated Drug for Bone Loss on Hind Limb Suspension Rat Model by NMR and Micro-CT
Advances in Bioscience and Bioengineering
Volume 1, Issue 1, June 2013, Pages: 1-7
Received: Apr. 17, 2013; Published: Jun. 14, 2014
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Qingwen Ni, Southwest Research Institute, San Antonio, TX, USA;Texas A&M International University, Laredo, TX, USA
Hong Dixon, Southwest Research Institute, San Antonio, TX, USA
Gloria Gutierrez, Southwest Research Institute, San Antonio, TX, USA
Long Bi, Southwest Research Institute, San Antonio, TX, USA
Yi-Xian Qin, State University of New York at Stony Brook, Stony Brook NY, USA
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A formulation of nano-encapsulated enantiomer of (+) promethazine with desired release rate has been synthesized for establish a localized drug delivery system. It was tested on a hind limb suspension (HLS) disuse rat model, and by using a non-destructive Nuclear Magnetic Resonance (NMR) relaxation technique, and micro computed tomography (Micro-CT) analysis technique to qualitatively evaluate the effectiveness of the new bone formations as well as to compare the current commercial anti-bone loss drug Alendeonate. Our studies suggest that nano-encapsulated (+) promethazine in controlled release formulations conjugating bone-targeting functional groups are effective in promoting bone growth in a disuse rat model
NANO-Encapsulation, Bone, NMR, Micro-CT
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Qingwen Ni, Hong Dixon, Gloria Gutierrez, Long Bi, Yi-Xian Qin, Characterization of Synthesized NANO-encapsulated Drug for Bone Loss on Hind Limb Suspension Rat Model by NMR and Micro-CT, Advances in Bioscience and Bioengineering. Vol. 1, No. 1, 2013, pp. 1-7. doi: 10.11648/
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