Plasma Protein Z Levels in Healthy and High-Risk Newborn Infants
American Journal of Bioscience and Bioengineering
Volume 2, Issue 6, December 2014, Pages: 78-82
Received: Nov. 24, 2014;
Accepted: Dec. 11, 2014;
Published: Jan. 21, 2015
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Ahmed Anower Khattab, Pediatrics department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt
Fathia Mohamed El Nemr, Pediatrics department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt
Rania Salah El Zayat, Pediatrics department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt
Mohmmed Soliman Rizk, Biochimistry Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt
Shimaa Fetouh Elbakly, Pediatrics resident, Tala Central Hospital, Tala, Menoufiya, Egypt
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Objectives: To evaluate plasma protein Z (PZ) levels in healthy and high-risk newborn infants. Background: Protein Z (PZ) is a vitamin K-dependent plasma protein , As is the case with other coagulation proteins and inhibitors, protein Z is consumed during disseminated intravascular coagulation (DIC), Functionally protein Z has been shown to be a direct requirement for the binding of thrombin to endothelial phospholipids , Protein Z also serves as a cofactor for the inhibition of coagulation factor Xa by a plasma serein called protein Z-dependent protease inhibitor (ZPI), The inhibitory function is exerted by the Protein Z- dependent protease inhibitor (ZPI), which circulates in the human plasma in a complex with PZ , The physiological function of protein Z is still rather ill-defined and may play role in high risk newborn. Methods: This study was conducted on 85 newborns divided in 4 groups ,(group I newborns affected by respiratory distress syndrome (RDS) , group II newborns from mothers with pre-eclampsia, group III newborns small for gestational age (SGA) and group IV healthy term and preterm newborns normal for gestational age. Newborns with sepsis, congenital malformation or hemorrhagic disorders were excluded, Plasma PZ levels was measured. Results: In the neonates of the study groups, protein z level was significant lower in patient group than control group, in group I ( 0.79 ±0.32), group II (0.70± 0.30), group III (0.78 ±0.32) and group IV (1.44 ±0.43) (p value<0.001). Conclusion: PZ deficiency occurs in newborns affected by severe RDS, in newborns from preeclampsic mothers and in SGA newborns, probably owing to activated coagulation in the first two conditions and to reduced PZ synthesis in the last one.
Hemostasis, Healthy Newborns, Newborns from Mothers Affected by Pre-Eclampsia and SGA Newborns, High-Risk Newborns, Protein Z, Respiratory Distress Syndrome
To cite this article
Ahmed Anower Khattab,
Fathia Mohamed El Nemr,
Rania Salah El Zayat,
Mohmmed Soliman Rizk,
Shimaa Fetouh Elbakly,
Plasma Protein Z Levels in Healthy and High-Risk Newborn Infants, American Journal of Bioscience and Bioengineering.
Vol. 2, No. 6,
2014, pp. 78-82.
Broze GJ, Jr(2004). Protein Z-dependent regulation of coagulation. J Thromb Haemost.;86:8-13.
Carl H. Backes, Kara Markham, Pamela Moorehead, Leandro Cordero, Craig A. Nankervis, and Peter J (2011). Giannone Maternal Preeclampsia and Neonatal Outcomes, J Pregnancy; 214365.
Corral, J., R. Gonzalez, D. Espinosa and V. Vicente, 2007. Protein Z/Z-dependent protease inhibitor (PZ/ZPI) anticoagulant system and thrombosis. Br. J. Haematol., 137: 99-108.|
Grignani G, Maiolo A. Cytokines and hemostasis. Haematologica 2002; 85: 967–72.
Idell, S., (2009). Anticoagulats for Acute respiratory distresss syndrome. Am. J. Respir. Crit. Care Med., 164: 517-520.
Kemkes-Matthes, B. and Matthes, K.J (2000)., Biomed Progress, 13, 51.
Ioannis , Taxiarchis , Spiridon G, Lefkothea D, Eleni D, Georgios V et al (2009). Protein Z Plasma Levels are Not Elevated in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy. The Open Ophthalmology Journal, 2009, 3, 15-19 15
Martin JA, Hamilton BE, Sutton PD, et al (2007). National Vital Statistics Reports.;56(6):1–103.
Offer E, , Debra H, Roberto Ro, Jimmy E , Luis G, Jyh K N, et al (2008). Preeclampsia Is Associated with Low Concentrations of Protein Z, J Matern Fetal Neonatal Med. 20(9): 661–667.
Rezaie, A 2005., J Biol Chem. September 23; 280(38).
Röhl, K Jäger D and Barth J (2006). Protein-Z-deficiency as a rare case of unexpected perioperative bleeding in a patient with spinal cord injury published online 44, 636–639.
Schettini, F., N. Laforgia, M. Altomare, A. Matuone and G.C. Del-Vecchio, 2004. Plasma protein Z levels in healthy and high-risk newborn infants. Acta Paediatr., 93: 654-657.
Tabatabai A, Fiehler R, Broze GJ, Jr(2010). Protein Zcirculates in plasma in a complex with protein Z dependent protease inhibitor. J Thromb Haemost.85:655-660.
Ware, L.B., M.A. Matthay, P.E. Parsons, B.T. Thompson, J.L. Januzzi and M.D. Eisner, (2007). Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Crit. Care Med., 35: 1821-1828. 15.
Yurdakok, M., A. Korkmaz, S. Kirazli, C. Aygun and S. Yigit, 2006. Global fibrinolytic capacity in Early Respiratory distress syndrome: A pilot study. Am. J. Hematol., 69: 255-257.