Fatty Acid Composition of Erythrocytes and Blood Plasma in Multiple Organ Dysfunction Syndrome

Alexander Osipenko

doi:doi:10.11648/j.bio.20150305.25

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Fatty Acid Composition of Erythrocytes and Blood Plasma in Multiple Organ Dysfunction Syndrome

Alexander Osipenko

Published in American Journal of Bioscience and Bioengineering (Volume 3, Issue 5)

Received: 1 December 2015 Accepted: Published: 1 December 2015

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Abstract

This paper focused on analysis of fatty acids of erythrocytes and blood plasma in patients with multiple organ dysfunction syndrome. For the study, fatty acids ethyl esters, obtained during sample preparation from blood plasma and erythrocytes, were analyzed by capillary gas-liquid chromatography. Statistical analysis was performed using the Mann-Whitney U test (p<0.05). The conducted research has shown that blood plasma of MODS patients has a decreased relative level of polyunsaturated fatty acids and saturated stearic (C18:0) acid, while there is a significant increase in relative content of monounsaturated fatty acids. In conditions of an increased level of monounsaturated palmitoleic (C16:1) and oleic (C18:1) fatty acids in blood plasma, only the level of palmitoleic (C16:1) acid is increased in erythrocytes. The disorder of lipid composition constancy of erythrocyte membranes is also manifested by a change in the content of saturated palmitic (C16:0) and polyunsaturated linoleic (C18:2) fatty acids. The changes revealed in fatty acid composition of erythrocytes may indicate systemic modifications of cell membranes in multiple organ dysfunction syndrome. The changes in blood plasma fatty acid composition in patients with multiple organ dysfunction syndrome is mainly caused by activation of lipolysis in fat depots.

Published in	American Journal of Bioscience and Bioengineering (Volume 3, Issue 5)
DOI	10.11648/j.bio.20150305.25
Page(s)	114-117
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Fatty Acids, Multiple Organ Dysfunction Syndrome, Erythrocytes, Blood Plasma

References

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[6]	J. Pontet, P. Contreras, A. Curbelo, J. Medina, S. Noveri, S. Bentancourt and E. R. Migliaro, “Heart rate variability as early marker of multiple organ dysfunction syndrome in septic patients”, J Crit Care, Vol. 18 No. 3, 2003, pp. 156-163.
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[13]	A. Andersson, C. Nälsén, S. Tengblad and B. Vessby, “Fatty acid composition of skeletal muscle reflects dietary fat composition in humans”, Am J Clin Nutr, Vol. 76 No. 6, 2002, pp. 1222-1229.
[14]	C. Hellmuth, H. Demmelmair, I. Schmitt, W. Peissner, M. Blüher and B. Koletzko, “Association between plasma nonesterified fatty acids species and adipose tissue fatty acid composition”, PLoS One, Vol. 8 No. 10, 2013, e74927.
[15]	G. T. Malcom, A. K. Bhattacharyya, M. Velez-Duran, M. A. Guzman, M. C. Oalmann and J. P. Strong, “Fatty acid composition of adipose tissue in humans: differences between subcutaneous sites”, Am J Clin Nutr, Vol. 50 No. 2, 1989, pp. 288-291.
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APA Style

Alexander Osipenko. (2015). Fatty Acid Composition of Erythrocytes and Blood Plasma in Multiple Organ Dysfunction Syndrome. American Journal of Bioscience and Bioengineering, 3(5), 114-117. https://doi.org/10.11648/j.bio.20150305.25

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ACS Style

Alexander Osipenko. Fatty Acid Composition of Erythrocytes and Blood Plasma in Multiple Organ Dysfunction Syndrome. Am. J. BioSci. Bioeng. 2015, 3(5), 114-117. doi: 10.11648/j.bio.20150305.25

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AMA Style

Alexander Osipenko. Fatty Acid Composition of Erythrocytes and Blood Plasma in Multiple Organ Dysfunction Syndrome. Am J BioSci Bioeng. 2015;3(5):114-117. doi: 10.11648/j.bio.20150305.25

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@article{10.11648/j.bio.20150305.25,
  author = {Alexander Osipenko},
  title = {Fatty Acid Composition of Erythrocytes and Blood Plasma in Multiple Organ Dysfunction Syndrome},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {3},
  number = {5},
  pages = {114-117},
  doi = {10.11648/j.bio.20150305.25},
  url = {https://doi.org/10.11648/j.bio.20150305.25},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20150305.25},
  abstract = {This paper focused on analysis of fatty acids of erythrocytes and blood plasma in patients with multiple organ dysfunction syndrome. For the study, fatty acids ethyl esters, obtained during sample preparation from blood plasma and erythrocytes, were analyzed by capillary gas-liquid chromatography. Statistical analysis was performed using the Mann-Whitney U test (p<0.05). The conducted research has shown that blood plasma of MODS patients has a decreased relative level of polyunsaturated fatty acids and saturated stearic (C18:0) acid, while there is a significant increase in relative content of monounsaturated fatty acids. In conditions of an increased level of monounsaturated palmitoleic (C16:1) and oleic (C18:1) fatty acids in blood plasma, only the level of palmitoleic (C16:1) acid is increased in erythrocytes. The disorder of lipid composition constancy of erythrocyte membranes is also manifested by a change in the content of saturated palmitic (C16:0) and polyunsaturated linoleic (C18:2) fatty acids. The changes revealed in fatty acid composition of erythrocytes may indicate systemic modifications of cell membranes in multiple organ dysfunction syndrome. The changes in blood plasma fatty acid composition in patients with multiple organ dysfunction syndrome is mainly caused by activation of lipolysis in fat depots.},
 year = {2015}
}

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TY  - JOUR
T1  - Fatty Acid Composition of Erythrocytes and Blood Plasma in Multiple Organ Dysfunction Syndrome
AU  - Alexander Osipenko
Y1  - 2015/12/01
PY  - 2015
N1  - https://doi.org/10.11648/j.bio.20150305.25
DO  - 10.11648/j.bio.20150305.25
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
SP  - 114
EP  - 117
PB  - Science Publishing Group
SN  - 2328-5893
UR  - https://doi.org/10.11648/j.bio.20150305.25
AB  - This paper focused on analysis of fatty acids of erythrocytes and blood plasma in patients with multiple organ dysfunction syndrome. For the study, fatty acids ethyl esters, obtained during sample preparation from blood plasma and erythrocytes, were analyzed by capillary gas-liquid chromatography. Statistical analysis was performed using the Mann-Whitney U test (p<0.05). The conducted research has shown that blood plasma of MODS patients has a decreased relative level of polyunsaturated fatty acids and saturated stearic (C18:0) acid, while there is a significant increase in relative content of monounsaturated fatty acids. In conditions of an increased level of monounsaturated palmitoleic (C16:1) and oleic (C18:1) fatty acids in blood plasma, only the level of palmitoleic (C16:1) acid is increased in erythrocytes. The disorder of lipid composition constancy of erythrocyte membranes is also manifested by a change in the content of saturated palmitic (C16:0) and polyunsaturated linoleic (C18:2) fatty acids. The changes revealed in fatty acid composition of erythrocytes may indicate systemic modifications of cell membranes in multiple organ dysfunction syndrome. The changes in blood plasma fatty acid composition in patients with multiple organ dysfunction syndrome is mainly caused by activation of lipolysis in fat depots.
VL  - 3
IS  - 5
ER  -

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Author Information

Alexander Osipenko

Resource Center, A. A. Kuleshov Mogilev State University, Mogilev, Belarus

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APA Style

Alexander Osipenko. (2015). Fatty Acid Composition of Erythrocytes and Blood Plasma in Multiple Organ Dysfunction Syndrome. American Journal of Bioscience and Bioengineering, 3(5), 114-117. https://doi.org/10.11648/j.bio.20150305.25

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ACS Style

Alexander Osipenko. Fatty Acid Composition of Erythrocytes and Blood Plasma in Multiple Organ Dysfunction Syndrome. Am. J. BioSci. Bioeng. 2015, 3(5), 114-117. doi: 10.11648/j.bio.20150305.25

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AMA Style

Alexander Osipenko. Fatty Acid Composition of Erythrocytes and Blood Plasma in Multiple Organ Dysfunction Syndrome. Am J BioSci Bioeng. 2015;3(5):114-117. doi: 10.11648/j.bio.20150305.25

Copy | Download

@article{10.11648/j.bio.20150305.25,
  author = {Alexander Osipenko},
  title = {Fatty Acid Composition of Erythrocytes and Blood Plasma in Multiple Organ Dysfunction Syndrome},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {3},
  number = {5},
  pages = {114-117},
  doi = {10.11648/j.bio.20150305.25},
  url = {https://doi.org/10.11648/j.bio.20150305.25},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20150305.25},
  abstract = {This paper focused on analysis of fatty acids of erythrocytes and blood plasma in patients with multiple organ dysfunction syndrome. For the study, fatty acids ethyl esters, obtained during sample preparation from blood plasma and erythrocytes, were analyzed by capillary gas-liquid chromatography. Statistical analysis was performed using the Mann-Whitney U test (p<0.05). The conducted research has shown that blood plasma of MODS patients has a decreased relative level of polyunsaturated fatty acids and saturated stearic (C18:0) acid, while there is a significant increase in relative content of monounsaturated fatty acids. In conditions of an increased level of monounsaturated palmitoleic (C16:1) and oleic (C18:1) fatty acids in blood plasma, only the level of palmitoleic (C16:1) acid is increased in erythrocytes. The disorder of lipid composition constancy of erythrocyte membranes is also manifested by a change in the content of saturated palmitic (C16:0) and polyunsaturated linoleic (C18:2) fatty acids. The changes revealed in fatty acid composition of erythrocytes may indicate systemic modifications of cell membranes in multiple organ dysfunction syndrome. The changes in blood plasma fatty acid composition in patients with multiple organ dysfunction syndrome is mainly caused by activation of lipolysis in fat depots.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Fatty Acid Composition of Erythrocytes and Blood Plasma in Multiple Organ Dysfunction Syndrome
AU  - Alexander Osipenko
Y1  - 2015/12/01
PY  - 2015
N1  - https://doi.org/10.11648/j.bio.20150305.25
DO  - 10.11648/j.bio.20150305.25
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
SP  - 114
EP  - 117
PB  - Science Publishing Group
SN  - 2328-5893
UR  - https://doi.org/10.11648/j.bio.20150305.25
AB  - This paper focused on analysis of fatty acids of erythrocytes and blood plasma in patients with multiple organ dysfunction syndrome. For the study, fatty acids ethyl esters, obtained during sample preparation from blood plasma and erythrocytes, were analyzed by capillary gas-liquid chromatography. Statistical analysis was performed using the Mann-Whitney U test (p<0.05). The conducted research has shown that blood plasma of MODS patients has a decreased relative level of polyunsaturated fatty acids and saturated stearic (C18:0) acid, while there is a significant increase in relative content of monounsaturated fatty acids. In conditions of an increased level of monounsaturated palmitoleic (C16:1) and oleic (C18:1) fatty acids in blood plasma, only the level of palmitoleic (C16:1) acid is increased in erythrocytes. The disorder of lipid composition constancy of erythrocyte membranes is also manifested by a change in the content of saturated palmitic (C16:0) and polyunsaturated linoleic (C18:2) fatty acids. The changes revealed in fatty acid composition of erythrocytes may indicate systemic modifications of cell membranes in multiple organ dysfunction syndrome. The changes in blood plasma fatty acid composition in patients with multiple organ dysfunction syndrome is mainly caused by activation of lipolysis in fat depots.
VL  - 3
IS  - 5
ER  -

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