Biosynthesis of Xylitol from Glucose: Microorganism, Key Enzymes and Genetically Engineered Strains
American Journal of Bioscience and Bioengineering
Volume 5, Issue 5, October 2017, Pages: 109-112
Received: Oct. 7, 2017;
Accepted: Oct. 19, 2017;
Published: Nov. 24, 2017
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Yilin Qi, College of Science and Technology, Hebei Agricultural University, Cangzhou, China
Huanhuan Zhang, School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China
Junhua Yun, School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China
Miaomiao Yang, School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China
Guoyan Zhang, School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China
Yanbo Xue, School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China
Xuexia Bai, School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China
Xianghui Qi, School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China
Yanqin Liu, College of Science and Technology, Hebei Agricultural University, Cangzhou, China
Longxian Ran, College of Forestry, Hebei Agricultural University, Baoding, China
Xylitol is an important prebiotics, and it is widely used in the fields of medicine and food. In view of the drawbacks of chemical method, much focus has been attracted into the study of xylitol biosynthesis. In this study, microorganism, method and key enzymes in the biosynthesis of xylitol were introduced. In addition, the production of xylitol from glucose by genetically engineered strains was summarized respectively.
Biosynthesis of Xylitol from Glucose: Microorganism, Key Enzymes and Genetically Engineered Strains, American Journal of Bioscience and Bioengineering.
Vol. 5, No. 5,
2017, pp. 109-112.
Qi, X. H., Zhu, J. F., Yun, J. H., Lin, J., Qi, Y. L., Guo, Q., Xu, H., 2016. Enhanced xylitol production: Expression of xylitol dehydrogenase from Gluconobacter oxydans and mixed culture of resting cell. Journal of Bioscience and Bioengineering. 122, 257-262.
Qi, X. H., Wang, X., Lin, J., Zhu, J. F., Luo, Y., Deng, W. Y., Wang, F., Sun, W. J., Meng, J. Z., 2014. Microbial and enzymatic process for xylitol production from D-glucose. Current Organic Chemistry, 18, 3131-3135.
Zhang, C., Zong, H., Zhuge, B., Lu, X., Fang, H., Zhuge, J., 2015. Production of Xylitol from D-Xylose by Overexpression of Xylose Reductase in Osmotolerant Yeast Candida glycerinogenes WL2002-5. Applied Biochemistry and Biotechnology, 176, 1511-1527.
Makinen, K. K., 2000. The rocky road of xylitol to its clinical application. Journal of Dental Research, 79, 1352-1355.
Mayer, G., Kulbe, K. D., Nidetzky, B., 2002. Utilization of xylitol dehydrogenase in a combined microbial/enzymatic process for production of xylitol from D-glucose. Applied Biochemistry and Biotechnology, 98-100, 577-589.
Matsushika, A., Watanabe, S., Kodaki, T., Makino, K., Sawayama, S., 2008. Bioethanol production from xylose by recombinant Saccharomyces cerevisiae expressing xylose reductase, NADP (+)-dependent xylitol dehydrogenase, and xylulokinase. Journal of Bioscience and Bioengineering, 105, 296-299.
Tamburini, E., Costa, S., Marchetti, M. G., Pedrini, P., 2015. Optimized Production of Xylitol from Xylose Using a Hyper-Acidophilic Candida tropicalis. Biomolecules. 5, 1979-1989.
Pratter, S. M., Eixelsberger, T., Nidetzky, B., 2015. Systematic strain construction and process development: Xylitol production by Saccharomyces cerevisiae expressing Candida tenuis xylose reductase in wild-type or mutant form. Bioresoure Technology, 198, 732-738.
Qi, X., Zhang, H., Magocha, T. A., An, Y., Yun, J., Yang, M., Xue, Y., Liang, S., Sun, W., Cao, Z., 2017. Improved xylitol production by expressing a novel D-arabitol dehydrogenase from isolated Gluconobacter sp. JX-05 and co-biotransformation of whole cells. Bioresoure Technology, 235, 50-58.
Onishi, H., Suzuki, T., 1969. Microbial production of xylitol from glucose. Applied Microbiology, 18, 1031-1035.
Sampaio, F. C., Mantovani, H. C., Passos, F. J. V., Moraes, C. A. d., Converti, A., Passos, F. M. L., 2005. Bioconversion of d-xylose to xylitol by Debaryomyces hansenii UFV-170: Product formation versus growth. Process Biochemistry, 40, 3600-3606.
Suzuki, T., Yokoyama, S., Kinoshita, Y., Yamada, H., Hatsu, M., Takamizawa, K., Kawai, K., 1999. Expression of xyrA gene encoding for D-Xylose reductase of Candida tropicalis and production of xylitol in Escherichia coli. Journal of Bioscience and Bioengineering, 87, 280-284.
Suzuki, S., Sugiyama, M., Mihara, Y., Hashiguchi, K., Yokozeki, K. 2002. Novel enzymatic method for the production of xylitol from D-arabitol by Gluconobacter oxydans. Bioscience Biotechnology and Biochemistry, Vol. 66, pp. 2614-2620.
Li, S., Zhang, J. L., Xu, H., Feng, X. H., 2016. Improved xylitol production from D-arabitol by enhancing the coenzyme regeneration efficiency of the pentose phosphate pathway in Gluconobacter oxydans. Journal of Agricultural and Food Chemistry, 64, 1144-1150.
Cheng, H. R., Jiang, N., Shen, A., Feng, Y. J., 2005. Molecular cloning and functional expression of D-arabitol dehydrogenase gene from Gluconobacter oxydans in Escherichia coli. FEMS Microbiology Letters, 252, 35-42.
Cheng, H. R., Li, Z. L., Jiang, N., Deng, Z. X., 2009. Cloning, Purification and characterization of an NAD-dependent D-arabitol dehydrogenase from Acetic Acid Bacterium, Acetobacter suboxydans. Protein Journal, 28, 263-272.
Granstrom, T. B., Izumori, K., Leisola, M., 2007. A rare sugar xylitol. Part II: biotechnological production and future applications of xylitol. Applied Microbiology and Biotechnology, 74, 273-276.
Povelainen, M., Miasnikov, A. N., 2006. Production of D-arabitol by a metabolic engineered strain of Bacillus subtilis. Biotechnology Journal, 1, 214-219.
Qi, X., Luo, Y., Wang, X., Zhu, J., Lin, J., Zhang, H., Chen, F., Sun, W., 2015. Enhanced D-arabitol production by Zygosaccharomyces rouxii JM-C46: isolation of strains and process of repeated-batch fermentation. Journal of Industrial Microbiology & Biotechnology, 42, 807-812.
Zhu, H. Y., Xu, H., Dai, X. Y., Zhang, Y., Ying, H.J., Ouyang, P. K., 2010. Production of D-arabitol by a newly isolated Kodamaea ohmeri. Bioprocess and Biosystems Engineering, 33, 565-571.
Zhang, J., Li, S., Xu, H., Zhou, P., Zhang, L., Ouyang, P., 2013. Purification of xylitol dehydrogenase and improved production of xylitol by increasing XDH activity and NADH supply in Gluconobacter oxydans. Journal of Agricultural and Food Chemistry, 61, 2861-2867.
Zhou, P., Li, S., Xu, H., Feng, X., Ouyang, P., 2012. Construction and co-expression of plasmid encoding xylitol dehydrogenase and a cofactor regeneration enzyme for the production of xylitol from D-arabitol. Enzyme and Microbial Technology, 51, 119-124.