Electronic Tool Interferences with Electrophysiology for the Psychiatric Disorders Monitoring
American Journal of Bioscience and Bioengineering
Volume 3, Issue 3-1, June 2015, Pages: 14-21
Received: Mar. 24, 2015; Accepted: Mar. 25, 2015; Published: Apr. 3, 2015
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Florin Babarada, Department of Electronics, Polytechnic University of Bucharest, ERG-BioNEC Group, Bucharest, Romania
Cristian Ravariu, Department of Electronics, Polytechnic University of Bucharest, ERG-BioNEC Group, Bucharest, Romania
Dan Prelipceanu, Department of Psychiatry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Bogdan Patrichi, Department of Psychiatry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Daniela Manuc, Public Health, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Aurora Salageanu, Cantacuzino National Research and Development Institute for Microbiology and Immunology, Bucharest, Romania
Iuliana Caras, Cantacuzino National Research and Development Institute for Microbiology and Immunology, Bucharest, Romania
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The paper presents a hardware solution of the in vivo electrophysiological signals acquiring and processing, using a continuous data acquisition on PC. The originality of the paper comes from architecture proposal, with some new blocks, which selective amplify and filter biosignals. One of the major problems in the electrophysiological signals monitoring is the impossibility to record the weak signals from deep organs that are covered by noise and by strong cardiac or muscular artefact signals. The analogical processing block is based on a dynamic range compressor, containing the automatic gain control block, so that the high power signals are less amplified than the low components. The following block is a clipper since to capture all the transitions that escape from the dynamic range compressor. At clipper output a low-pass filter is connected since to abruptly cut the high specific bio-frequencies. The data vector recording is performing by strong internal resources microcontroller including ten bits A/D conversion port. Through some specific measurements and calibration the chain can be used to capture and then interprets the neuronal signal with well applications in public health monitoring like psychiatric disorders.
Healthcare, Compressor Technique, Bioinformatics, Signal Processing, Public Heath, Psychiatric
To cite this article
Florin Babarada, Cristian Ravariu, Dan Prelipceanu, Bogdan Patrichi, Daniela Manuc, Aurora Salageanu, Iuliana Caras, Electronic Tool Interferences with Electrophysiology for the Psychiatric Disorders Monitoring, American Journal of Bioscience and Bioengineering. Special Issue: Bio-Electronics: Biosensors, Biomedical Signal Processing, and Organic Engineering. Vol. 3, No. 3-1, 2015, pp. 14-21. doi: 10.11648/j.bio.s.2015030301.13
Květina, J.; Varayil, J.E; Ali, S.M; Kuneš, M.; Bureš, J.; Tachecí, I.; Rejchrt, S. & Kopáčová, M., Preclinical electrogastrography in experimental pigs. International Journal of Interdiscip. Toxicol., Vol.3, No.2, (June 2010), pp. 53-58.
C. Costa Santos, J. Bernardes, P.M.B. Vitanyi, L. Antunes. Clustering fetal heart rate tracing by compression. 2006, pp.1-6, available at
Bogdan, D.; Craciun, M.; Dochia, R.I.; Ionescu, M.A. & Ravariu, C. (2009). Circuit design for noise rejection in electromyography, Proc. of INGIMED 2009 2nd National Conference on Biomedical Engineering, pp. 76-81, Bucharest, Romania, ICPE-CA Publisher, November 12-14, 2009
D. Careglio, J. Solé Pareta, S. Spadaro. Service category-to-wavelength selection technique for QoS support in connection-oriented optical packet switching, The International Journal of Computer and Telecommunications Networking, Volume 51 Issue 1, 17 January 2007. DOI: 10.1016/j.comnet.2006.04.008.
B. Firtat, R. Iosub, D. Necula, F. Babarada, E. Franti, C. Moldovan, (2008) Simulation, design and microfabrication of multichannel microprobe for bioelectrical signals recording, IEEE Int. Conf., Sinaia, Romania, 2008, pp 177-180.
F. Babarada, J. Arhip, (2009) Electrophysiology Signal Data Vector Acquiring, Congress of Romanian Medical Association, Bucharest, 2009, pp . 82-83
Fen-Ying Kong, Sai-Xi Gu, Wei-Wei Li, Ting-Ting Chen, Qin Xu, Wei Wang, A paper disk equipped with graphene/polyaniline/Au nanoparticles/glucose oxidase biocomposite modified screen-printed electrode: Toward hole blood glucose determination, Biosensors and Bioelectronics, Volume 56, 15 June 2014, Pages 77-82.
Ravariu, R. Botan, The Electrical Transport Mechanisms Investigation In Adrenergic Synapses Using A Parallel BioOI Biodevice, 19th IEEE International EURASIP Conference of Biosignal, Brno, Czech Republic, under IEEE Engineering in Medicine and Biology Society, Jun. 29-30. 2008, pp.63.115-118.
Ricardo M. Santos, João Laranjinha, Rui M. Barbosa, Anton Sirota, Simultaneous measurement of cholinergic tone and neuronal network dynamics in vivo in the rat brain using a novel choline oxidase based electrochemical biosensor, Biosensor and Bioelectronics, vol. 69, no. 7, July 2015, pp. 83-94.
Mohamed Basiouny Alghannam, Mohamed Ramadan El-Kholy, Ashraf Anas Zytoon, Ayman Mohamed Ebied, The Role of MRI and MR Arthrography in Evaluation of Wrist Pain, International Science PG Journal of Medical Imaging. Vol. 2, No. 6, 2014, pp. 149-155.
C. Ravariu, D. Ursutiu, F. Babarada, J. Arhip, S. S. Arama, G. Radulian, C. Samoila. Remote Measurements of the Gastric Electrical Signals - Between Theory and Practice, 11-th Int. IEEE Conference on Remote Engineering and Virtual Instrumentation, Porto, Portugal, Proceedings pp. 281-284, 2014.
Ahmed Saad Al-Ghabban, Abbas Fathil Al-Hashimi, Ziad Tariq Al-Dahan, Predominant Peak Detection of QRS Complexes, International Science PG Journal of Medical Imaging. Vol. 2, No. 6, 2014, pp. 133-137.
Wenqiong Xue, Jian Kang, F. DuBois Bowman, Tor D. Wager, and Jian Guo, Identifying functional co-activation patterns in neuroimaging studies via Poisson graphical models, Biometrics, Vol. 70, No. 4, pp. 234-239, December 2014.
Cristian Ravariu, Ala Bondarciuc. The sensitivity in the IR spectrum of the intact and pathological tissues by laser bio-photometry, Laser in Medical Science, Springer Journal, March 2014, Volume 29, Issue 2, pp 581-588.
Shah S, Bougherara H, Schemitsch EH, Zdero R (2012) Biomechanical stress maps of an artificial femur obtained using a new infrared thermography technique validated by strain gages. Medical 553 Engineering & Physics, 2012, vol. 34, pp. 1496–1502.
Rowena Jacob, Kiriakos Xenitidis and Colin Campbell, How to interpret different results for CRHTT data, The British Journal of Psychiatry, (2011) 199, 249–254.
M. G.-Serbanescu, C. Diaconu, S. Herms, C. Bleotu, J. Vollmer, T.W. Muhleisen, D. Prelipceanu,L. Priebe, R. Mihailescu, M-J. Georgescu, D. Sima, M. Grimberg, M. M. Nothen and S. Cichon, Investigation of the tryptophan hydroxylase 2 gene in bipolar I disorder in the Romanian population, Psychiatric Genetics, Oct. 2008, vol. 18, no.5, pp. 240-247.
Mohammad Movassat, Nasser Ashgriz, Bob Cheung, Blast Wave Induced Flows in Semicircular Canals, Science PG American Journal of Bioscience and Bioengineering. Vol. 3, No. 1, 2015, pp. 1-7.
C. Ravariu, C.I. Tirgoviste, O. Dumitrache. The modeling of the insulin exocytosys after a glycemic stimulus, paper ID 723-088, 8-th IASTED International Conference Biomedical Engineering BioMED, 2011, Innsbruck, Austria, pp. 188-191.
C. Ravariu, A. Bondarciuc, V. Nahaba, V. Bondarciuc, C. I. Tirgoviste, F. Babarada, O. Dumitrache. The laser biophotometry medical applications for the diabetes foot monitoring, Elsevier Journal of Photodyagnosis and Photodynamic Therapy, vol. 7, suppl. 1, pp. 522-523, July 2010.
Michael Davidson, Silvana Galderisi, Mark Weiser, Nomi Werbeloff, Wolfgang W. Fleischhacker, Richard S. Keefe, Han Boter, Ireneus P.M. Keet, Dan Prelipceanu, Janusz K. Rybakowski, Jan Libiger, Martina Hummer, Sonia Dollfus, Juan J. López-Ibor, Luchezar G. Hranov, Wolfgang Gaebel, Joseph Peuskens, Nils Lindefors, Anita Riecher-Rössler, René S. Kahn, Cognitive Effects of Antipsychotic Drugs in First-Episode Schizophrenia and Schizophreniform Disorder: A Randomized, Open-Label Clinical Trial EUFEST, American Journal of Psychiatry, June 2009 Vol. 166, no. 6, pp. 675–682.
C. Ravariu, C. Ionescu-Tirgoviste, F. Ravariu. Glucose biofuels properties in the bloodstream in conjunction with the beta cell electro-physiology, Proceedings of 2-nd Edition IEEE - ICCEP International Conference on Clean Electrical Power Conference, Jun. 09-11. 2009, Capri, Italy, pp. 124-127.
Armida Mucci, Umberto Volpe, Nash Boutros, Evidence-Based Medicine and Electrophysiology in Schizophrenia, Clinical EEG and Neuroscience, April 2009 vol. 40, no. 2, pp. 62-77.
Gerard J. Marek, George K. Aghajanian, The electrophysiology of prefrontal serotonin systems: therapeutic implications for mood and psychosis, Biological Psychiatry, Dec 1998, vol. 44, no 11, pp. 1118-1127.
Coles, Michael G.H.; Michael D. Rugg (1996). "Event-related brain potentials: an introduction". Electrophysiology of Mind. Oxford Scholarship Online Monographs. pp. 1–27.
Carol Jahshan1,2, Jonathan K. Wynn1,2, Kristopher I. Mathis1,2 & Michael F. Green, The neurophysiology of biological motion perception in schizophrenia, Brain and Behavior, doi: 10.1002/brb3.303, pp. 76 - 84.
Robert J Barry, Adam R Clarke, Stuart J Johnston, A review of electrophysiology in attention-deficit/hyperactivity disorder: I. Qualitative and quantitative electroencephalography, Clinical Neurophysiology, Volume 114, Issue 2, February 2003, Pages 171–183.
Lenartowicz A, Delorme A, Walshaw PD, Cho AL, Bilder RM, McGough JJ, McCracken JT, Makeig S, Loo SK, Electroencephalography correlates of spatial working memory deficits in attention-deficit/hyperactivity disorder: vigilance, encoding, and maintenance, Journal of Neuroscience, Jan 2014 22; 34(4), pp. 1171-82.
Rustem Popa, (2006) Medical Electronics. Matrix House, Bucharest Publishing House, Romania, in Romanian.
ATMega32 data sheet, available at http://www.atmel.com/dyn/resources/prod_ documents/doc2503.pdf
T-Y. Tu, C-Y. Chen, D-S. Jong and A. M. Wo, "An integrated electrophysiological and optical approach for ion channel study in a microfluidic system enabling intra- and extra-cellular solution exchange", Sensors and Actuators B: Chemical, vol. 185, pp. 496–503, August 2013.
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