@article{10.11648/j.bio.20170503.11,
  author = {Luai Fadi Madanat and Dina Wahib Shaban and Hamzeh Mohamad Naghawi and Haneen Samir Saker and Moaath Alsmady and Handan Ankarali and Tunc Eren and Orhan Alimoglu},
  title = {A Meta-Analysis of Antibiotics Versus Surgery for the Treatment of Acute Appendicitis},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {5},
  number = {3},
  pages = {75-82},
  doi = {10.11648/j.bio.20170503.11},
  url = {https://doi.org/10.11648/j.bio.20170503.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20170503.11},
  abstract = {Appendectomy is the mainstay of treatment for acute appendicitis. Considering the complications of surgery, antibiotic treatment has also been gaining increasing interest in cases of acute appendicitis. This study aimed to compare the efficacy of antibiotics to surgery for acute uncomplicated appendicitis. The PubMed, Medline, Medscape and Cochrane databases were searched for studies comparing antibiotics versus surgery. The six outcome measures identified were thirty-day post-therapeutic peritonitis, length of hospital stay, prevalence of total complications, prevalence of normal appendix, prevalence of mean duration of pain and duration of disability. Five prospective RCTs with a total of 1430 patients (644 in the antibiotic group and 786 in the surgical group) were included in this study. Antibiotic treatment had a success rate of 75.3%. Regarding overall mean duration of disability, the antibiotic group had a significantly shorter duration of disability than that of the surgery group (P < 0.05). The total number of complications in the antibiotic group was 3.6% while that of the surgical group was 11.6%. The overall difference for mean duration of pain, and length of hospital stay between antibiotic therapy and surgery were not found to be statistically significant (P > 0.05). Although the conservative approach has a success rate lower than appendectomy, it is a possible alternative in certain clinical scenarios. Appendectomy remains the mainstay treatment for acute appendicitis. However, additional studies clarifying the certain etiologies of appendicitis that are responsive to antibiotic treatment are needed to further support its use.},
 year = {2017}
}

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TY  - JOUR
T1  - A Meta-Analysis of Antibiotics Versus Surgery for the Treatment of Acute Appendicitis
AU  - Luai Fadi Madanat
AU  - Dina Wahib Shaban
AU  - Hamzeh Mohamad Naghawi
AU  - Haneen Samir Saker
AU  - Moaath Alsmady
AU  - Handan Ankarali
AU  - Tunc Eren
AU  - Orhan Alimoglu
Y1  - 2017/08/18
PY  - 2017
N1  - https://doi.org/10.11648/j.bio.20170503.11
DO  - 10.11648/j.bio.20170503.11
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
SP  - 75
EP  - 82
PB  - Science Publishing Group
SN  - 2328-5893
UR  - https://doi.org/10.11648/j.bio.20170503.11
AB  - Appendectomy is the mainstay of treatment for acute appendicitis. Considering the complications of surgery, antibiotic treatment has also been gaining increasing interest in cases of acute appendicitis. This study aimed to compare the efficacy of antibiotics to surgery for acute uncomplicated appendicitis. The PubMed, Medline, Medscape and Cochrane databases were searched for studies comparing antibiotics versus surgery. The six outcome measures identified were thirty-day post-therapeutic peritonitis, length of hospital stay, prevalence of total complications, prevalence of normal appendix, prevalence of mean duration of pain and duration of disability. Five prospective RCTs with a total of 1430 patients (644 in the antibiotic group and 786 in the surgical group) were included in this study. Antibiotic treatment had a success rate of 75.3%. Regarding overall mean duration of disability, the antibiotic group had a significantly shorter duration of disability than that of the surgery group (P < 0.05). The total number of complications in the antibiotic group was 3.6% while that of the surgical group was 11.6%. The overall difference for mean duration of pain, and length of hospital stay between antibiotic therapy and surgery were not found to be statistically significant (P > 0.05). Although the conservative approach has a success rate lower than appendectomy, it is a possible alternative in certain clinical scenarios. Appendectomy remains the mainstay treatment for acute appendicitis. However, additional studies clarifying the certain etiologies of appendicitis that are responsive to antibiotic treatment are needed to further support its use.
VL  - 5
IS  - 3
ER  - 

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