Monosodium glutamate (MSG) is a compound popularly used to enhance food taste and flavor. Several reports of toxicity studies on MSG are contradictory. Therefore, there is growing concern regarding the safety of MSG as food additive. In the present study, the effect of orally administered MSG on food consumption, body weight and some biochemical and hematological parameters were investigated in adult rats. Following a 28-day treatment with 5-15 mg/kg body weight MSG, there were no significant changes in packed cell volume (PCV), hemoglobin concentration (HB), red blood cell (RBC) and white blood cell (WBC) counts. No significant change was also observed in all the biochemical parameters studied, including indices of hepatic and renal functions. The results of this study suggest that MSG at the doses administered is not hazardous to health.
| Published in | American Journal of BioScience (Volume 1, Issue 1) |
| DOI | 10.11648/j.ajbio.20130101.13 |
| Page(s) | 11-15 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Monosodium Glutamate, Toxicity, Body Weight, Food Additive, Enzymes
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APA Style
Oyetunji Timothy Kolawole. (2013). Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats. American Journal of BioScience, 1(1), 11-15. https://doi.org/10.11648/j.ajbio.20130101.13
ACS Style
Oyetunji Timothy Kolawole. Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats. Am. J. BioScience 2013, 1(1), 11-15. doi: 10.11648/j.ajbio.20130101.13
AMA Style
Oyetunji Timothy Kolawole. Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats. Am J BioScience. 2013;1(1):11-15. doi: 10.11648/j.ajbio.20130101.13
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Download@article{10.11648/j.ajbio.20130101.13,
author = {Oyetunji Timothy Kolawole},
title = {Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats},
journal = {American Journal of BioScience},
volume = {1},
number = {1},
pages = {11-15},
doi = {10.11648/j.ajbio.20130101.13},
url = {https://doi.org/10.11648/j.ajbio.20130101.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20130101.13},
abstract = {Monosodium glutamate (MSG) is a compound popularly used to enhance food taste and flavor. Several reports of toxicity studies on MSG are contradictory. Therefore, there is growing concern regarding the safety of MSG as food additive. In the present study, the effect of orally administered MSG on food consumption, body weight and some biochemical and hematological parameters were investigated in adult rats. Following a 28-day treatment with 5-15 mg/kg body weight MSG, there were no significant changes in packed cell volume (PCV), hemoglobin concentration (HB), red blood cell (RBC) and white blood cell (WBC) counts. No significant change was also observed in all the biochemical parameters studied, including indices of hepatic and renal functions. The results of this study suggest that MSG at the doses administered is not hazardous to health.},
year = {2013}
}
TY - JOUR T1 - Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats AU - Oyetunji Timothy Kolawole Y1 - 2013/06/20 PY - 2013 N1 - https://doi.org/10.11648/j.ajbio.20130101.13 DO - 10.11648/j.ajbio.20130101.13 T2 - American Journal of BioScience JF - American Journal of BioScience JO - American Journal of BioScience SP - 11 EP - 15 PB - Science Publishing Group SN - 2330-0167 UR - https://doi.org/10.11648/j.ajbio.20130101.13 AB - Monosodium glutamate (MSG) is a compound popularly used to enhance food taste and flavor. Several reports of toxicity studies on MSG are contradictory. Therefore, there is growing concern regarding the safety of MSG as food additive. In the present study, the effect of orally administered MSG on food consumption, body weight and some biochemical and hematological parameters were investigated in adult rats. Following a 28-day treatment with 5-15 mg/kg body weight MSG, there were no significant changes in packed cell volume (PCV), hemoglobin concentration (HB), red blood cell (RBC) and white blood cell (WBC) counts. No significant change was also observed in all the biochemical parameters studied, including indices of hepatic and renal functions. The results of this study suggest that MSG at the doses administered is not hazardous to health. VL - 1 IS - 1 ER -
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