Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases

Md. Shamim Hossain; Md. Ashrafuzzaman Sapon; Naim Hassan

doi:doi:10.11648/j.ajbio.20140206.16

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Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases

Md. Shamim Hossain, Md. Ashrafuzzaman Sapon, Naim Hassan

Published in American Journal of BioScience (Volume 2, Issue 6)

Received: 23 October 2014 Accepted: 6 November 2014 Published: 18 December 2014

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Abstract

There are seven SIRT isoforms in mammals, with different biological activities including gene regulation, metabolism and apoptosis. Despite recent controversy about sirtuins function in some organisms, among them SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. SIRT3 is a member of the sirtuin family of NAD+ dependent deacetylases, which is localized to the mitochondria and is enriched in kidney, brown adipose tissue, heart, and other metabolically active tissues. It is an endogenous negative regulator of cardiac hypertrophy, which protects hearts by suppressing cellular levels of ROS and modulates mitochondrial intermediary metabolism and fatty acid utilization during fasting. Another one, Hydrogen sulfide is produced within the human body, and relaxes the vascular endothelium and smooth muscle cells, which is important to maintaining clean arteries as one age. It functions as an antioxidant and inhibits expression of pro-inflammatory factors, all of which imply an important role in aging and age-associated diseases. The aim of this review is to find out the anti aging properties of SIRT3 and H2S that can be used to extend the life span of human as a preventive and therapeutic agent.

Published in	American Journal of BioScience (Volume 2, Issue 6)
DOI	10.11648/j.ajbio.20140206.16
Page(s)	222-232
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

SIRT3, H2S, ROS, Aging

References

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Md. Shamim Hossain, Md. Ashrafuzzaman Sapon, Naim Hassan. (2014). Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases. American Journal of BioScience, 2(6), 222-232. https://doi.org/10.11648/j.ajbio.20140206.16

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Md. Shamim Hossain; Md. Ashrafuzzaman Sapon; Naim Hassan. Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases. Am. J. BioScience 2014, 2(6), 222-232. doi: 10.11648/j.ajbio.20140206.16

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AMA Style

Md. Shamim Hossain, Md. Ashrafuzzaman Sapon, Naim Hassan. Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases. Am J BioScience. 2014;2(6):222-232. doi: 10.11648/j.ajbio.20140206.16

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@article{10.11648/j.ajbio.20140206.16,
  author = {Md. Shamim Hossain and Md. Ashrafuzzaman Sapon and Naim Hassan},
  title = {Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases},
  journal = {American Journal of BioScience},
  volume = {2},
  number = {6},
  pages = {222-232},
  doi = {10.11648/j.ajbio.20140206.16},
  url = {https://doi.org/10.11648/j.ajbio.20140206.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20140206.16},
  abstract = {There are seven SIRT isoforms in mammals, with different biological activities including gene regulation, metabolism and apoptosis. Despite recent controversy about sirtuins function in some organisms, among them SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. SIRT3 is a member of the sirtuin family of NAD+ dependent deacetylases, which is localized to the mitochondria and is enriched in kidney, brown adipose tissue, heart, and other metabolically active tissues. It is an endogenous negative regulator of cardiac hypertrophy, which protects hearts by suppressing cellular levels of ROS and modulates mitochondrial intermediary metabolism and fatty acid utilization during fasting. Another one, Hydrogen sulfide is produced within the human body, and relaxes the vascular endothelium and smooth muscle cells, which is important to maintaining clean arteries as one age. It functions as an antioxidant and inhibits expression of pro-inflammatory factors, all of which imply an important role in aging and age-associated diseases. The aim of this review is to find out the anti aging properties of SIRT3 and H2S that can be used to extend the life span of human as a preventive and therapeutic agent.},
 year = {2014}
}

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TY  - JOUR
T1  - Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases
AU  - Md. Shamim Hossain
AU  - Md. Ashrafuzzaman Sapon
AU  - Naim Hassan
Y1  - 2014/12/18
PY  - 2014
N1  - https://doi.org/10.11648/j.ajbio.20140206.16
DO  - 10.11648/j.ajbio.20140206.16
T2  - American Journal of BioScience
JF  - American Journal of BioScience
JO  - American Journal of BioScience
SP  - 222
EP  - 232
PB  - Science Publishing Group
SN  - 2330-0167
UR  - https://doi.org/10.11648/j.ajbio.20140206.16
AB  - There are seven SIRT isoforms in mammals, with different biological activities including gene regulation, metabolism and apoptosis. Despite recent controversy about sirtuins function in some organisms, among them SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. SIRT3 is a member of the sirtuin family of NAD+ dependent deacetylases, which is localized to the mitochondria and is enriched in kidney, brown adipose tissue, heart, and other metabolically active tissues. It is an endogenous negative regulator of cardiac hypertrophy, which protects hearts by suppressing cellular levels of ROS and modulates mitochondrial intermediary metabolism and fatty acid utilization during fasting. Another one, Hydrogen sulfide is produced within the human body, and relaxes the vascular endothelium and smooth muscle cells, which is important to maintaining clean arteries as one age. It functions as an antioxidant and inhibits expression of pro-inflammatory factors, all of which imply an important role in aging and age-associated diseases. The aim of this review is to find out the anti aging properties of SIRT3 and H2S that can be used to extend the life span of human as a preventive and therapeutic agent.
VL  - 2
IS  - 6
ER  -

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Md. Shamim Hossain

Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Kushtia-7003, Bangladesh
Md. Ashrafuzzaman Sapon

Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Kushtia-7003, Bangladesh; Bioscience Division, Graduate school of Science & Technology, Shizuoka University, Shizuoka, Japan
Naim Hassan

Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Kushtia-7003, Bangladesh

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Md. Shamim Hossain, Md. Ashrafuzzaman Sapon, Naim Hassan. (2014). Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases. American Journal of BioScience, 2(6), 222-232. https://doi.org/10.11648/j.ajbio.20140206.16

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Md. Shamim Hossain; Md. Ashrafuzzaman Sapon; Naim Hassan. Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases. Am. J. BioScience 2014, 2(6), 222-232. doi: 10.11648/j.ajbio.20140206.16

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AMA Style

Md. Shamim Hossain, Md. Ashrafuzzaman Sapon, Naim Hassan. Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases. Am J BioScience. 2014;2(6):222-232. doi: 10.11648/j.ajbio.20140206.16

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@article{10.11648/j.ajbio.20140206.16,
  author = {Md. Shamim Hossain and Md. Ashrafuzzaman Sapon and Naim Hassan},
  title = {Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases},
  journal = {American Journal of BioScience},
  volume = {2},
  number = {6},
  pages = {222-232},
  doi = {10.11648/j.ajbio.20140206.16},
  url = {https://doi.org/10.11648/j.ajbio.20140206.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20140206.16},
  abstract = {There are seven SIRT isoforms in mammals, with different biological activities including gene regulation, metabolism and apoptosis. Despite recent controversy about sirtuins function in some organisms, among them SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. SIRT3 is a member of the sirtuin family of NAD+ dependent deacetylases, which is localized to the mitochondria and is enriched in kidney, brown adipose tissue, heart, and other metabolically active tissues. It is an endogenous negative regulator of cardiac hypertrophy, which protects hearts by suppressing cellular levels of ROS and modulates mitochondrial intermediary metabolism and fatty acid utilization during fasting. Another one, Hydrogen sulfide is produced within the human body, and relaxes the vascular endothelium and smooth muscle cells, which is important to maintaining clean arteries as one age. It functions as an antioxidant and inhibits expression of pro-inflammatory factors, all of which imply an important role in aging and age-associated diseases. The aim of this review is to find out the anti aging properties of SIRT3 and H2S that can be used to extend the life span of human as a preventive and therapeutic agent.},
 year = {2014}
}

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TY  - JOUR
T1  - Hydrogen Sulfide and SIRT3 Gene, the Strong Preventive and Therapeutic Agent in Aging and Age Related Diseases
AU  - Md. Shamim Hossain
AU  - Md. Ashrafuzzaman Sapon
AU  - Naim Hassan
Y1  - 2014/12/18
PY  - 2014
N1  - https://doi.org/10.11648/j.ajbio.20140206.16
DO  - 10.11648/j.ajbio.20140206.16
T2  - American Journal of BioScience
JF  - American Journal of BioScience
JO  - American Journal of BioScience
SP  - 222
EP  - 232
PB  - Science Publishing Group
SN  - 2330-0167
UR  - https://doi.org/10.11648/j.ajbio.20140206.16
AB  - There are seven SIRT isoforms in mammals, with different biological activities including gene regulation, metabolism and apoptosis. Despite recent controversy about sirtuins function in some organisms, among them SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. SIRT3 is a member of the sirtuin family of NAD+ dependent deacetylases, which is localized to the mitochondria and is enriched in kidney, brown adipose tissue, heart, and other metabolically active tissues. It is an endogenous negative regulator of cardiac hypertrophy, which protects hearts by suppressing cellular levels of ROS and modulates mitochondrial intermediary metabolism and fatty acid utilization during fasting. Another one, Hydrogen sulfide is produced within the human body, and relaxes the vascular endothelium and smooth muscle cells, which is important to maintaining clean arteries as one age. It functions as an antioxidant and inhibits expression of pro-inflammatory factors, all of which imply an important role in aging and age-associated diseases. The aim of this review is to find out the anti aging properties of SIRT3 and H2S that can be used to extend the life span of human as a preventive and therapeutic agent.
VL  - 2
IS  - 6
ER  -

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