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Serum Neopterin Level in Early Onset Neonatal Sepsis
American Journal of BioScience
Volume 3, Issue 3, May 2015, Pages: 80-86
Received: Apr. 17, 2015; Accepted: Apr. 22, 2015; Published: May 5, 2015
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Fathia Sayed El Nemer, Pediatric Department, Faculty of Medicine, Menoufyia University, Shebin al-Kom, Egypt
Dina Abdel Razek Midan, Pediatric Department, Faculty of Medicine, Menoufyia University, Shebin al-Kom, Egypt
Ahmed Fouad Mohamed, Pediatric Department, Faculty of Medicine, Menoufyia University, Shebin al-Kom, Egypt; Zagazig medical center – Ministry of Health Sharkia, Egypt
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Objective: The Aim of the study is to evaluate the diagnostic and prognostic values of serum neopterin level in neonatal sepsis and to evaluate risk factors for neonatal sepsis in neonatal intensive care unit of Menoufyia University hospital. Background: Neonatal sepsis has been used to describe the systemic response to infection in the newborn infant younger than one month age. Neopterin is one of biochemical markers of immune activity, which seems to be useful in monitoring inflammatory diseases. Increased concentration of neopterin in serum is observed in conditions with involvement of cellmediated immune response. Methods: Our study was conducted on 88 neonates recruited from NICU of and divided to Group І (suspected sepsis), It includes 35 neonates with symptoms and signs suggestive of sepsis or at high risk of infection. Group ІІ (proven sepsis), It includes 38 neonates who are septic with clinical picture of sepsis and laboratory data showing sepsis, Group Ш (Controls), It includes 15 healthy neonates with no evidence of sepsis, all groups were subjected to history taking, clinical examination and laboratory Investigations included complete blood count, blood cultures, Quantitative C-reactive protein (CRP) and Serum neopterin level. Results: Serum neopterin was significantly high in Group I (44.46±24.72) and Group II (108.37±22.38) than in controls and the best cutoff value of serum neopterin to detect sepsis is 70.56 nmol/L with sensitivity 94.7% and specificity 88.6% .and that neopetrin correlated well with mortalities due to sepsis. Conclusion: Neopterin found to be a diagnostic and prognostic factor in patients with sepsis.
Neopterin, C-Reactive Protein (Crp), Neonatal Sepsis
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Fathia Sayed El Nemer, Dina Abdel Razek Midan, Ahmed Fouad Mohamed, Serum Neopterin Level in Early Onset Neonatal Sepsis, American Journal of BioScience. Vol. 3, No. 3, 2015, pp. 80-86. doi: 10.11648/j.ajbio.20150303.13
Chacko B, Sohi I. Early onset neonatal sepsis.Indian J Pediatr.2005 Jan;72(1):23-6.
Lawn JE, Cousens S, Zupan J; Lancet Neonatal Survival Steering Team. 4 million neonatal deaths: when? Where? Why? Lancet. 2005 Mar 5-11;365 (9462):891-900.
Shankar M J, Agarwal R and Deorariak et al. sepsis in the newborn. AIIMS-NICU Protocols. 2008 :1-18.
Ucar B, Yildiz B, Aksit MA, Yarar C, Colak O, Akbay Y, Colak E. Serum amyloid A, procalcitonin, tumor necrosis factor-alpha, and interleukin-1beta levels in neonatal late-onset sepsis. Mediators Inflamm. 2008; 2008:737141.
Vineet Bhandari, Chao Wang, Christine Rinder and Henry Rinder. Hematologic Profile of Sepsis in Neonates: Neutrophil CD64 as a Diagnostic Marker. Pediatrics 2008;121;129-134.
Hawak.C-reactive protien in neonatal sepsis, the journal of neonatal nursing, neonatal network 2008;(23)2:117-120.
Cesur S. Neopterin: a marker used for monitoring infections. Mikrobiyol Bul.2005 Apr;39(2):251-60.
Ip M, Rainer TH, Lee N, et al. Value of serum procalcitonin; neopterin; and C-reactive protein in differentiating bacterial from viral etiologies in patients presenting with lower respiratory tract infections. Diagn Microbiol Infect Dis 2007;59: 131-6.
Khinchi Y R, Kumar A, Yadav S .Profile of Neonatal sepsis. Journal of college of Medical Sciences-Nepal, 2010 ;6(2): 1-6.
Arnon S, LitmanovitzI .Diagnostic tests in neonatal sepsis. Curr Opin Infect Dis,2008 ;21(3):223-227.
Takala A, Nupponen I, Kylänpää-Bäck ML, et al. .Markers of inflammation in sepsis. Ann Med,2002 ; 34(7-8):614-23.
Yousef ARA . Interleukin-1 and phospholipase A2 in septic newborns. Thesis submitted for partial fulfillment of master degree in pediatrics, faculty of medicine, Ain-Shams University. Supervised by Ismail IS, Imam SS, Shaheen KY - 2003.
Gomella TL, Cunningham MD, Eyal FG and ZenkEK . Tricia Lacy Gomella clinical manual of neonatology (5 thed). McGraw-Hill Co. 2004; 434-440.
Abdel-Hady HE and ZakiME: Evaluation of soluble E-selectin as a marker for neonatal sepsis. The Egyptian journal of neonatology,2003; 4 (2): 69-78.
Badrawi NH, Bashir MM, Iskander IF and Saied DA: Neonatal infections in NICU: magnitude of the problem. Kasr El-Aini Medical Journal,2005 ;11(5):181-195.
Boseila S, Seoud I, Samy G, et al .Serum Neopterin Level in Early Onset Neonatal Sepsis. Journal of American Science ,2011; 7(7): 343-352.
Mah MP, Aeberhard EE, Gilliam MB and Sherman MP :Effects of pentoxifylline on in vivo leukocyte function and clearance of group B streptococci from preterm rabbit lung. Crit Care Me, May 2002 ; 21(5): 712-20.
Fergany AL .Serum cortisol and thyroid hormone levels in neonates with sepsis. Thesis submitted for partial fulfillment of Master degree in Pediatrics, Faculty of Medicine, Ain- Shams University. Supervised by El Barbari MN, Imam SS, Shaheen KY-2006.
El-Raggal NM, El-Barbary MN, Youssef MF, El-Mansy HA. Neutrophil surface antigens CD11b and CD64 expression: a potential predictor of early-onset neonatal sepsis. Egypt J Pediatr Allergy Immunol, 2004; 2 (2): 90-100.
Carrigan SD, Scott G and TabrizianM .Toward resolving the challenges of sepsis diagnosis.ClinChem, 2004 ; 50:1301–1314.
Ng PC .Diagnostic markers of infection in neonates. Arch Dis Child Fetal Neonatal Ed, 2004 ; 89(3):F229-35.
MitakaC . Clinical laboratory differentiation of infectious versus non- infectious systemic inflammatory response syndrome ClinChimActa, 2005 ; 351:17.
Tasdelen Fisgin N, Aliyazicioglu Y, Tanyel E, et al .The value of neopterin and procalcitonin in patients with sepsis. South Med J,2010 ; 103(3):216-9.
Baydar T, Yuksel O, Sahin TT, et al .Neopterin as a prognostic biomarker in intensive care unit patients. J Crit Care, 2009; 24(3): 318-21.
Ruokonen E, Ilkka L, Niskanen M and TakalaJ.Procalcitonin and neopterin as indicators of infection in critically ill patients. ActaAnaesthesiol Scand,2002; 46(4):398-404.
Murr C, Widner B, Wirleitner B and Fuchs D Neopterin as a Marker for Immune System Activation.J. Current Drug Metabolism ,2002 ;3:175-187.
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