Influence of Beta-2-Adrenergic Receptor Gln27Glu Polymorphism on the Autonomic Heart Rate Modulation in Young Sedentary and Physically Active Women
American Journal of BioScience
Volume 3, Issue 5, September 2015, Pages: 190-196
Received: Aug. 12, 2015; Accepted: Aug. 17, 2015; Published: Aug. 29, 2015
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Authors
Rebelo Ana Cristina Silva, Department of Morphology, Biological Sciences Institute, Federal University of Goiás, Goiânia, Brazil
Melo Aryanne Batista Soares, Center for Neuroscience and Cardiovascular Physiology Research, Department of Physiological Sciences, Biological Sciences Institute, Federal University of Goiás, Goiânia, Brazil
Salviati Mariana Rodrigues, Humana Performance Research Group - College of Health Sciences (FACIS), Methodist University of Piracicaba (UNIMEP), Piracicaba, Brazil
Verlengia Rozangela, Humana Performance Research Group - College of Health Sciences (FACIS), Methodist University of Piracicaba (UNIMEP), Piracicaba, Brazil
Vale Arthur Ferreira Do, Department of Morphology, Biological Sciences Institute, Federal University of Goiás, Goiânia, Brazil
Nogueira Yanley Lucio, Faculty of Medicine, Federal University of Goiás, Goiânia, Brazil
Tamburús Nayara Yamada, Department of Physiotherapy, Federal University of Sao Carlos, Sao Carlos, Brazil
Kunz Vandeni Clarice, Adventist University of Sao Paulo, Engenheiro Coelho, Sao Paulo, Brazil
Silva Ester Da, Department of Physiotherapy, Federal University of Sao Carlos, Sao Carlos, Brazil
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Abstract
Background: Studies have shown an interaction between the autonomic heart rate (HR) modulation and genetic polymorphisms. Nevertheless, it is yet unclear how a particular genetic polymorphism may determine a pattern of autonomic HR control, especially regarding the role of physical exercise. The objective was to investigate the influence of of Beta-2-Adrenergic (β2-AR) Gln27Glu polymorphisms and exercise on HRV of young Brazilian women. Methods: The group was selected as Sedentary Group (SG; n = 88) and physically Active Group (AG; n = 99). The β2-AR polymorphisms were analyzed using PCR-RFLP. The amplicons were subjected to electrophoresis on a 10% acrylamide gel and stained with ethidium bromide. The HR was registered in real time for 15 minutes, in the supine-position. The heart rate variability (HRV) was analysed using Shannon’s entropy (SE), conditional entropy (complexity index [CInd] and normalized CInd [NCI]), and symbolic analysis (0V%, 1V%, 2LV%, and 2ULV%). Statistical analysis: Analysis of variance (ANOVA) with Fisher's Least. Results: AG presented higher values for SE and 2ULV%, and lower values for 0V% when compared to SG (p<0.05). There was no significant difference of any index among genotypes both from the complexity and symbolic analysis. The interaction between genotype and exercise did not significantly affect HRV. Conclusion: These results do not support the concept that the β2-AR Gln27Glu polymorphisms affects the HRV indexes in physically active or sedentary women.
Keywords
β2-Adrenergic Polymorphism, Heart Rate Variability, Non-Linear Analysis, Women, Exercise
To cite this article
Rebelo Ana Cristina Silva, Melo Aryanne Batista Soares, Salviati Mariana Rodrigues, Verlengia Rozangela, Vale Arthur Ferreira Do, Nogueira Yanley Lucio, Tamburús Nayara Yamada, Kunz Vandeni Clarice, Silva Ester Da, Influence of Beta-2-Adrenergic Receptor Gln27Glu Polymorphism on the Autonomic Heart Rate Modulation in Young Sedentary and Physically Active Women, American Journal of BioScience. Vol. 3, No. 5, 2015, pp. 190-196. doi: 10.11648/j.ajbio.20150305.15
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