The Study of Comparative Analgesic Activity of Lidocaine and Ropivacaine on Albino Rats
American Journal of BioScience
Volume 2, Issue 6-1, November 2014, Pages: 1-5
Received: Jun. 5, 2014; Accepted: Jul. 4, 2014; Published: Jul. 13, 2014
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Thota. Madhu Chaithanya, Department of Pharmacology Maharajah’s Institute of Medical Sciences, Nellimarla, Vizianagaram , Andhra Pradesh, India
MundllaMudi. Prasad Naidu, Research scholar in Department of Biochemistry Naryana Medical College and Hospital Nellore, Andhra Pradesh, India
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Analgesics are the drugs which possess significant pain relieving properties by acting on the CNS or peripheral pain receptors without significantly affecting consciousness. Lidocaine and Ropivacaine are well studied individually; but there are conflicting reports of the comparison of actions between these two drugs both in experimental and clinical trials. Total of 30 rats were taken, they were divided into six groups each containing 5 rats. The analgesic activity of drugs was studied by measuring drug-induced changes in the sensitivity of the pre-screened mice to heat stress applied to their tails (reaction time: 2-4 sec). With increasing the dose of the analgesics from 6.25 to 25µg/kg the analgesic action occurred earlier. A clinical significance is that Lidocaine has its some better analgesic effect than Ropivacaine. As known, the dose of Lidocaine for local anesthetic action is < 7mgs/kg body weight, and of Ropivacaine it is <8mgs/kg body weight. But in our study a dose of the analgesics was low, up to 25µg/kg only. Because of this low dose, the mechanism of analgesic action of the drugs is different, and it is discussed in this paper.
Lidocaine, Ropivacaine, Analgesics, Albino Rats
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Thota. Madhu Chaithanya, MundllaMudi. Prasad Naidu, The Study of Comparative Analgesic Activity of Lidocaine and Ropivacaine on Albino Rats, American Journal of BioScience. Special Issue: Chemical Biology. Vol. 2, No. 6-1, 2014, pp. 1-5. doi: 10.11648/j.ajbio.s.2014020601.11
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