Patent Foramen Ovale is Associated with an Increased NAFLD Risk for Health of Young Men
American Journal of BioScience
Volume 2, Issue 6-1, November 2014, Pages: 35-38
Received: Aug. 13, 2014; Accepted: Aug. 19, 2014; Published: Aug. 24, 2014
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Erkan Kibrisli, Family Physician, Dicle University Hospital, Yenişehir, Diyarbakir, Turkey
Sinan Işcen, Cardiologist, Diyarbakir Military Hospital, Yenişehir, Diyarbakir, Turkey
Salim Ozenc, Family Physician, Diyarbakir Military Hospital, Yenişehir, Diyarbakir, Turkey
Adem Parlak, Family Physician, Presidential Guard Regiment, Ankara, Turkey
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Between March 2012 and July 2013, 1000 asymptomatic young military male underwent hepatic ultrasonography and echocardiography at Medical Check-up Center for general young health screening. Blood biochemistry, arterial blood pressure and anthropometric measurements were studied. All analyses were performed using the statistical package SPSS 15.0, where the statistical significance was assessed at the two-tailed 0.05 threshold. It was found that among 1000 persons, 60 had patent foramen ovale (PFO) and 110 subjects had symptoms of nonalcoholic fatty liver disease (NAFLD). The PFO-group consisted of 20 male with 33.3% of NAFLD symptoms, while the group without PFO consisted of 90 male with 9.6% of NAFLD symptoms only. There were significant differences between two groups: p<0.001. Moreover, such factors as the mean age, BMI, triglycerides, hemoglobin, and aspartate aminotransferase level, the mean HDL cholesterol, alanine aminotransferase, platelet count did not differ between the two groups. The main cause of the pathogenesis of nonalcoholic fatty liver disease (NAFLD) has not been sufficiently elucidated. Serotonin of plasma is removed from circulation in capillary beds, predominantly in the lung. Nevertheless, metabolism of serotonin can be by-passed by patent foramen ovale (PFO) that can lead to NAFLD. Therefore, the aim of this study was to test the hypothesis that echocardiographic diagnosed PFO predicts the subsequent NAFLD, which can be diagnosed by ultrasonography. The statistical analysis of the 1000 young male supports the hypothesis that PFO can be associated with increased NAFLD risk for the health of young men.
Non-Alcoholic Fatty Liver Disease (NAFLD), Patent Foramen Ovale (PFO), Serotonin
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Erkan Kibrisli, Sinan Işcen, Salim Ozenc, Adem Parlak, Patent Foramen Ovale is Associated with an Increased NAFLD Risk for Health of Young Men, American Journal of BioScience. Special Issue: Chemical Biology. Vol. 2, No. 6-1, 2014, pp. 35-38. doi: 10.11648/j.ajbio.s.2014020601.16
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