Nephrotoxic Effects of Arsenic in Albino Mice
American Journal of BioScience
Volume 4, Issue 3-1, May 2016, Pages: 1-4
Received: Nov. 24, 2015; Accepted: Jan. 3, 2016; Published: Feb. 23, 2016
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Authors
Suman Sharma, Department of Zoology & Environmental Sciences, Punjabi University, Patiala, India
Anjali Singh Gill, Department of Zoology & Environmental Sciences, Punjabi University, Patiala, India
Zorawar Singh, Department of Zoology, Khalsa College, Amritsar, Punjab, India
Charanjit Kaur, Department of Zoology & Environmental Sciences, Punjabi University, Patiala, India
P. Vijaya, Department of Zoology & Environmental Sciences, Punjabi University, Patiala, India
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Abstract
Arsenic is an ubiquitous element in the environment. In the present study we investigated the effects of arsenic trioxide (AsIII) on lipid peroxidation and on the activity of antioxidant enzymes in the kidney of albino mice. Albino mice were divided into three groups. Group I were kept as control. Group II were administrated an oral dose of arsenic trioxide (3mg/kg b.w.). Group III were given an oral dose of arsenic trioxide (6mg/kg b.w.). They were acclimatized for 15 days before administration of arsenic trioxide. The autopsies were done from all the groups at 15 days post-treatment. Malondialdehyde (MDA) and activities of Superoxide dismutase (SOD) and Catalase (CAT) were analyzed in kidney of albino mice. The results showed a significant increase in concentration of MDA (p<0.05). Activities of SOD and CAT were found to decrease significantly (p<0.05). The results indicated that arsenic induced oxidative stress in albino mice by producing free radicals and lipid peroxidation where antioxidant enzymes were used as biomarkers.
Keywords
Arsenic, Malondialdehyde, Lipid Peroxidation, Oxidative Stress, CAT, SOD
To cite this article
Suman Sharma, Anjali Singh Gill, Zorawar Singh, Charanjit Kaur, P. Vijaya, Nephrotoxic Effects of Arsenic in Albino Mice, American Journal of BioScience. Special Issue: Recent Trends in Experimental Toxicology. Vol. 4, No. 3-1, 2016, pp. 1-4. doi: 10.11648/j.ajbio.s.2016040301.11
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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