International Journal of Biomedical Materials Research

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Radiographic, Histologic and Mechanical Comparison of NanoFUSE® DBM and a Bioactive Glass in a Rabbit Spinal Fusion Model

Received: 02 July 2015    Accepted: 21 July 2015    Published: 31 July 2015
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Abstract

Autologous bone has long been the gold standard for bone void fillers. However, the limited supply and morbidity associated with using autologous graft material has led to the development of many different bone graft substitutes. The use of bone graft extenders has become an essential component in a number of orthopedic applications including spinal fusion. This study compares the ability of NanoFUSE® DBM and a bioactive glass product (NovaBone Putty®) to induce spinal fusion in a rabbit model. NanoFUSE® DBM is a combination of allogeneic human bone and bioactive glass. NanoFUSE® DBM alone, and in combination with autograft, and NovaBone Putty®, were implanted in the posterior lateral intertransverse process region of the rabbit spine. The spines were evaluated for fusion at 4, 8, 12, and 24 weeks for fusion of the L4-L5 transverse processes using a total of 64 skeletally mature rabbits. Samples were evaluated by manual palpation, radiographically, histologically, and by mechanical testing. Radiographical, histological, and palpation measurements demonstrated the ability of NanoFUSE® DBM to induce new bone formation. The material in combination with autograft performed as well as autograft alone with respect to new bone formation and bridging bone at all time points with the exception of four week radiographic analyses. In addition, the combination of allogeneic human bone and bioactive glass found in NanoFUSE® DBM was observed to be superior to the bioactive glass product NovaBone Putty® in this rabbit model of spinal fusion. This in vivo study demonstrates the DBM and bioactive glass combination, NanoFUSE® DBM, could be an effective bone graft extender in posterolateral spinal fusions.

DOI 10.11648/j.ijbmr.20150303.11
Published in International Journal of Biomedical Materials Research (Volume 3, Issue 3, June 2015)
Page(s) 19-33
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Demineralized Bone Matrix, Bioactive Glass, Spinal Fusion, Radiography, Histology

References
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Author Information
  • Research and Development Department, Nanotherapeutics, Inc., Alachua, FL

  • Research and Development Department, Nanotherapeutics, Inc., Alachua, FL

  • Ibex Preclinical Research, Inc., Logan, UT

  • Research and Development Department, Nanotherapeutics, Inc., Alachua, FL

  • Research and Development Department, Nanotherapeutics, Inc., Alachua, FL

  • Research and Development Department, Nanotherapeutics, Inc., Alachua, FL

  • Research and Development Department, Nanotherapeutics, Inc., Alachua, FL

  • Research and Development Department, Nanotherapeutics, Inc., Alachua, FL

  • Research and Development Department, Nanotherapeutics, Inc., Alachua, FL

  • Research and Development Department, Nanotherapeutics, Inc., Alachua, FL

Cite This Article
  • APA Style

    James F. Kirk, Gregg Ritter, Michael J. Larson, Robert C. Waters, Isaac finger, et al. (2015). Radiographic, Histologic and Mechanical Comparison of NanoFUSE® DBM and a Bioactive Glass in a Rabbit Spinal Fusion Model. International Journal of Biomedical Materials Research, 3(3), 19-33. https://doi.org/10.11648/j.ijbmr.20150303.11

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    ACS Style

    James F. Kirk; Gregg Ritter; Michael J. Larson; Robert C. Waters; Isaac finger, et al. Radiographic, Histologic and Mechanical Comparison of NanoFUSE® DBM and a Bioactive Glass in a Rabbit Spinal Fusion Model. Int. J. Biomed. Mater. Res. 2015, 3(3), 19-33. doi: 10.11648/j.ijbmr.20150303.11

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    AMA Style

    James F. Kirk, Gregg Ritter, Michael J. Larson, Robert C. Waters, Isaac finger, et al. Radiographic, Histologic and Mechanical Comparison of NanoFUSE® DBM and a Bioactive Glass in a Rabbit Spinal Fusion Model. Int J Biomed Mater Res. 2015;3(3):19-33. doi: 10.11648/j.ijbmr.20150303.11

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  • @article{10.11648/j.ijbmr.20150303.11,
      author = {James F. Kirk and Gregg Ritter and Michael J. Larson and Robert C. Waters and Isaac finger and John Waters and John H. Abernethy and Dhyana Sankar and James D. Talton and Ronald R. Cobb},
      title = {Radiographic, Histologic and Mechanical Comparison of NanoFUSE® DBM and a Bioactive Glass in a Rabbit Spinal Fusion Model},
      journal = {International Journal of Biomedical Materials Research},
      volume = {3},
      number = {3},
      pages = {19-33},
      doi = {10.11648/j.ijbmr.20150303.11},
      url = {https://doi.org/10.11648/j.ijbmr.20150303.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijbmr.20150303.11},
      abstract = {Autologous bone has long been the gold standard for bone void fillers. However, the limited supply and morbidity associated with using autologous graft material has led to the development of many different bone graft substitutes. The use of bone graft extenders has become an essential component in a number of orthopedic applications including spinal fusion. This study compares the ability of NanoFUSE® DBM and a bioactive glass product (NovaBone Putty®) to induce spinal fusion in a rabbit model. NanoFUSE® DBM is a combination of allogeneic human bone and bioactive glass. NanoFUSE® DBM alone, and in combination with autograft, and NovaBone Putty®, were implanted in the posterior lateral intertransverse process region of the rabbit spine. The spines were evaluated for fusion at 4, 8, 12, and 24 weeks for fusion of the L4-L5 transverse processes using a total of 64 skeletally mature rabbits. Samples were evaluated by manual palpation, radiographically, histologically, and by mechanical testing. Radiographical, histological, and palpation measurements demonstrated the ability of NanoFUSE® DBM to induce new bone formation. The material in combination with autograft performed as well as autograft alone with respect to new bone formation and bridging bone at all time points with the exception of four week radiographic analyses. In addition, the combination of allogeneic human bone and bioactive glass found in NanoFUSE® DBM was observed to be superior to the bioactive glass product NovaBone Putty® in this rabbit model of spinal fusion. This in vivo study demonstrates the DBM and bioactive glass combination, NanoFUSE® DBM, could be an effective bone graft extender in posterolateral spinal fusions.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Radiographic, Histologic and Mechanical Comparison of NanoFUSE® DBM and a Bioactive Glass in a Rabbit Spinal Fusion Model
    AU  - James F. Kirk
    AU  - Gregg Ritter
    AU  - Michael J. Larson
    AU  - Robert C. Waters
    AU  - Isaac finger
    AU  - John Waters
    AU  - John H. Abernethy
    AU  - Dhyana Sankar
    AU  - James D. Talton
    AU  - Ronald R. Cobb
    Y1  - 2015/07/31
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ijbmr.20150303.11
    DO  - 10.11648/j.ijbmr.20150303.11
    T2  - International Journal of Biomedical Materials Research
    JF  - International Journal of Biomedical Materials Research
    JO  - International Journal of Biomedical Materials Research
    SP  - 19
    EP  - 33
    PB  - Science Publishing Group
    SN  - 2330-7579
    UR  - https://doi.org/10.11648/j.ijbmr.20150303.11
    AB  - Autologous bone has long been the gold standard for bone void fillers. However, the limited supply and morbidity associated with using autologous graft material has led to the development of many different bone graft substitutes. The use of bone graft extenders has become an essential component in a number of orthopedic applications including spinal fusion. This study compares the ability of NanoFUSE® DBM and a bioactive glass product (NovaBone Putty®) to induce spinal fusion in a rabbit model. NanoFUSE® DBM is a combination of allogeneic human bone and bioactive glass. NanoFUSE® DBM alone, and in combination with autograft, and NovaBone Putty®, were implanted in the posterior lateral intertransverse process region of the rabbit spine. The spines were evaluated for fusion at 4, 8, 12, and 24 weeks for fusion of the L4-L5 transverse processes using a total of 64 skeletally mature rabbits. Samples were evaluated by manual palpation, radiographically, histologically, and by mechanical testing. Radiographical, histological, and palpation measurements demonstrated the ability of NanoFUSE® DBM to induce new bone formation. The material in combination with autograft performed as well as autograft alone with respect to new bone formation and bridging bone at all time points with the exception of four week radiographic analyses. In addition, the combination of allogeneic human bone and bioactive glass found in NanoFUSE® DBM was observed to be superior to the bioactive glass product NovaBone Putty® in this rabbit model of spinal fusion. This in vivo study demonstrates the DBM and bioactive glass combination, NanoFUSE® DBM, could be an effective bone graft extender in posterolateral spinal fusions.
    VL  - 3
    IS  - 3
    ER  - 

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