Thyroid Pathology of Cypermethrin and Its Reproductive Implications in Yankasa Rams
International Journal of Biomedical Materials Research
Volume 4, Issue 3, December 2016, Pages: 43-48
Received: Oct. 5, 2016; Accepted: Oct. 29, 2016; Published: Dec. 29, 2016
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Authors
Ubah Simon Azubuike, Department of Theriogenology, Faculty of Veterinary Medicine, University of Abuja, Federal Capital Territory, Nigeria
Ogwu David, Department of Theriogenology and Production, Faculty of Veterinary Medicine, Ahmadu Bello University Zaria, Kaduna, Nigeria
Rekwot Peter Ibrahim, Department of Theriogenology and Production, Faculty of Veterinary Medicine, Ahmadu Bello University Zaria, Kaduna, Nigeria
Rwuaan Joseph Sankey, Department of Theriogenology and Production, Faculty of Veterinary Medicine, Ahmadu Bello University Zaria, Kaduna, Nigeria
Chibuogwu Ijeoma Chika, Animal Science Department, Faculty of Agriculture, University of Abuja, Federal Capital Territory, Nigeria
Sambo Sohnap James, Department of Veterinary Pathology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Kaduna, Nigeria
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Abstract
An investigation into the pathological effects of Cypermethrin on the thyroid gland of Yankasa rams was carried out. Sixteen sexually-mature, healthy Yankasa rams aged 18 - 30 months and weighing between 21.5 - 46.5kg with clinically normal genitalia were used. They were divided equally into two groups (A and B). A served as the treatment group while B served as the control. (A) were given Cypermethrin (3%) at the dose rate of 3mg/kg (0.1ml/kg) body weight, topically as pour-on. (B)were given distilled water at the same dose rate of 0.1ml/kg body weight topically as pour-on. These treatments were repeated every two weeks for a period of 12 weeks. The rams were sacrificed at the end of 12 weeks and the following organs (liver, heart, kidney, brain and thyroid gland), were collected for gross and histopathology. Results showed that no gross pathologic lesions were found on the thyroid gland, theliver, brain and the kidneys of both groups. The heart of the treated group showed petechial hemorrhage. The mean weights of the following organs; liver, thyroid gland, kidneys and heart of the treated and the control groups were 400.00±0.00g and 420.00±20.0g; 2.30±0.37g and 1.50±0.31g; 70.20±9.90g and 72.60±3.70;127.51±46 and 100.00±20.00respectively. The differences in weight between the two groups were not significantly different (P>0.05). Histologic sections of the thyroid glands of the treated group showed hyperplasia of the follicular epithelial cells followed by collapsing of the follicles. Histologic sections of the cardiac muscles of the treated group showed focal infiltration of lymphocytes and loss of striations (degeneration). The liver, the kidneysand thebrain (cerebrum) of both groups showed no histologic lesions. It was concluded that Cypermethrin induced thyroid and cardiac pathology in the rams. It was recommended that more investigation be done to unravel the mechanism of inducing thyroid and cardiac pathology in rams.
Keywords
Thyroid, Pathology, Cypermethrin, Reproduction, Rams
To cite this article
Ubah Simon Azubuike, Ogwu David, Rekwot Peter Ibrahim, Rwuaan Joseph Sankey, Chibuogwu Ijeoma Chika, Sambo Sohnap James, Thyroid Pathology of Cypermethrin and Its Reproductive Implications in Yankasa Rams, International Journal of Biomedical Materials Research. Vol. 4, No. 3, 2016, pp. 43-48. doi: 10.11648/j.ijbmr.20160403.16
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Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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