Preparation of a Novel Chitosan/Glycerol/Matrine Drug-Loading Film and the Study of Its Release Behavior in Vitro
International Journal of Biomedical Materials Research
Volume 6, Issue 1, March 2018, Pages: 20-25
Received: Mar. 20, 2018; Accepted: Apr. 2, 2018; Published: May 8, 2018
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Chunlei Zhang, Department of Stomatology, The First Affiliated Hospital, Jinan University, Guangzhou, China; School of Stomatology, Jinan University, Guangzhou, China
Jinghua Li, The Third Affiliated School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
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Based on matrine (Mat), chitosan (CS) and carboxymethyl chitosan (CMC) as a plant source drug and a carrier material. A novel Mat/CS drug-loading film and Mat/CS/CMC drug-loading film were prepared. The mechanical properties, surface morphology and drug-loading capacity of the drug-loading film were characterized in vitro. The results showed that the mechanical strength had maximum value and the tensile modulus was up to 0.79 MPa when the molecular weight of CS was 650,000 and the mass ratio of CS/glycerol was 1:1.4. The aggregate distribution of the Mat was located in the bottom surface of the film and was asymmetrical by SEM observation. Via release behavior tests in vitro, the drug-loading film showed high drug-loading capacity and long slowing-release properties. The release time of the drug-loading film increased along with the increase of CS molecular weight. When the bottom of the drug-loading film was coated with a layer of 1% carboxymethyl chitosan, the release times of the drug-loading film was increased to 108 h. Thus, we conclude that the matrix materials of the drug-loading film are natural, green, nontoxic and biodegradable, and the preparation method is simple and avoid using a large number of organic solvents. The novel drug-loading film can obviously prolong release of drugs.
Chitosan, Matrine, Drug-Loading Film, Release Behavior
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Chunlei Zhang, Jinghua Li, Preparation of a Novel Chitosan/Glycerol/Matrine Drug-Loading Film and the Study of Its Release Behavior in Vitro, International Journal of Biomedical Materials Research. Vol. 6, No. 1, 2018, pp. 20-25. doi: 10.11648/j.ijbmr.20180601.14
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