Preparation of a Novel Chitosan/Glycerol/Matrine Drug-Loading Film and the Study of Its Release Behavior in Vitro
International Journal of Biomedical Materials Research
Volume 6, Issue 1, March 2018, Pages: 20-25
Received: Mar. 20, 2018; Accepted: Apr. 2, 2018; Published: May 8, 2018
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Chunlei Zhang, Department of Stomatology, The First Affiliated Hospital, Jinan University, Guangzhou, China; School of Stomatology, Jinan University, Guangzhou, China
Jinghua Li, The Third Affiliated School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
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Based on matrine (Mat), chitosan (CS) and carboxymethyl chitosan (CMC) as a plant source drug and a carrier material. A novel Mat/CS drug-loading film and Mat/CS/CMC drug-loading film were prepared. The mechanical properties, surface morphology and drug-loading capacity of the drug-loading film were characterized in vitro. The results showed that the mechanical strength had maximum value and the tensile modulus was up to 0.79 MPa when the molecular weight of CS was 650,000 and the mass ratio of CS/glycerol was 1:1.4. The aggregate distribution of the Mat was located in the bottom surface of the film and was asymmetrical by SEM observation. Via release behavior tests in vitro, the drug-loading film showed high drug-loading capacity and long slowing-release properties. The release time of the drug-loading film increased along with the increase of CS molecular weight. When the bottom of the drug-loading film was coated with a layer of 1% carboxymethyl chitosan, the release times of the drug-loading film was increased to 108 h. Thus, we conclude that the matrix materials of the drug-loading film are natural, green, nontoxic and biodegradable, and the preparation method is simple and avoid using a large number of organic solvents. The novel drug-loading film can obviously prolong release of drugs.
Chitosan, Matrine, Drug-Loading Film, Release Behavior
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Chunlei Zhang, Jinghua Li, Preparation of a Novel Chitosan/Glycerol/Matrine Drug-Loading Film and the Study of Its Release Behavior in Vitro, International Journal of Biomedical Materials Research. Vol. 6, No. 1, 2018, pp. 20-25. doi: 10.11648/j.ijbmr.20180601.14
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G. F. Caetano, M. A. Frade, T. A. Andrade, M. N. Leite, C. Z. Bueno, A. M. Moraes, J. T. Ribeiro-Paes, Chitosan-alginate membranes accelerate wound healing, J Biomed Mater Res B Appl Biomater, 2015, (103): 1013-1022.
M. B. Dowling, R. Kumar, M. A. Keibler, J. R. Hess, G. V. Bochicchio, S. R. Raghavan, A self-assembling hydrophobically modified chitosan capable of reversible hemostatic action, Biomaterials, 2011, (32): 3351-3357.
J. F. Barata, R. J. Pinto, V. I. Vaz Serra, A. J. Silvestre, T. Trindade, M. G. Neves, J. A. Cavaleiro, S. Daina, P. Sadocco, C. S. Freire, Fluorescent Bioactive Corrole Grafted-Chitosan Films, Biomacromolecules, 2016, (17): 1395-1403.
J. X. Chen, H. H. Shen, M. Niu, Y. M. Guo, X. Q. Liu, Y. Z. Han, Y. M. Zhang, Y. L. Zhao, B. K. Bai, W. J. Zhou, X. H. Xiao, Anti-hepatitis B virus effect of matrine-type alkaloid and involvement of p38 mitogen-activated protein kinase and tumor necrosis factor receptor-associated factor 6, Virus Res, 2016, (215): 104-113.
G. L. Zhang, L. Jiang, Q. Yan, R. H. Liu, L. Zhang, Anti-tumor effect of matrine combined with cisplatin on rat models of cervical cancer, Asian Pac J Trop Med, 2015, (8): 1055-1059.
J. Huang, H. Xu, Matrine: Bioactivities and Structural Modifications, Curr Top Med Chem, 2016, (16): 3365-3378.
J. Yong, X. Wu, C. Lu, Anticancer Advances of Matrine and Its Derivatives, Curr Pharm Des, 2015, (21): 3673-3680.
W. C. Lin, C. C. Lien, H. J. Yeh, C. M. Yu, S. H. Hsu, Bacterial cellulose and bacterial cellulose-chitosan membranes for wound dressing applications, Carbohydr Polym, 2013, (94): 603-611.
M. J. Simoes, A. Gartner, Y. Shirosaki, R. M. Gil da Costa, P. P. Cortez, F. Gartner, J. D. Santos, M. A. Lopes, S. Geuna, A. S. Varejao, A. C. Mauricio, In vitro and in vivo chitosan membranes testing for peripheral nerve reconstruction, Acta Med Port, 2011, (24): 43-52.
S. Simsek, H. I. Canter, E. Konas, P. Korkusuz, D. Demir, F. Oner, I. Unsal, M. E. Mavili, A new concept in treatment of burn injury: controlled slow-release granulocyte-monocyte colony-stimulating factor chitosan gel system, Ann Plast Surg, 2011, (67): 583-588.
L. L. Zhang, P. Li, Y. M. Li, A. Q. Wang, Preparation and characterization of magnetic alginate-chitosan hydrogel beads loaded matrine, Drug Dev Ind Pharm, 2012, (38): 872-882.
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