Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug
International Journal of Biomedical Materials Research
Volume 7, Issue 1, June 2019, Pages: 16-23
Received: Jan. 16, 2019; Accepted: Feb. 20, 2019; Published: Mar. 6, 2019
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Jiunn-An Pan, Graduate Institution Engineering Technology-Doctoral, National Taipei University of Technology, Taipei, Taiwan; New Taipei Municipal Yonghe Junior High School, New Taipei City, Taiwan
Hsuan-Liang Liu, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan
Ko-Shao Chen, Department of Materials Engineering, Tatung University, Taipei, Taiwan
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Hybrid hydrogel was fabricated by a classic sol-gel method using EDC/NHS as crosslink reagent grafting onto the thermoplastic polyurethane (TPU), nonwoven fabric, for controlled release of drug. In this study, precursor acetic acid (AA) was used to plasma deposit on the surface of TPU to form a hydrophilic thin film. Hybrid hydrogel was investigated through scanning electron microscopy (SEM), water contact angle (WCA) measurement, Fourier transform infra-red (FTIR) spectroscopy, UV/V is spectroscopy, equilibrium swelling ratio, MTT assay and drug delivery system studies. This polyelectrolyte complexes (PECs) formed hydrogel, pH-sensitive type, was evaluated at pH value of 1.2 and 7.4 of buffer solution and at temperature of 37C to observe its rate of swelling and drug release features with caffeine. Moreover, the mechanism of caffeine release from membrane devices (n=0.58) are anomalous transport, non-Fickian diffusion, the value of n lies between 0.43 and 0.85. It has an excellent release ratio up to about 90% absorption cumulative amounts of caffeine at pH 7.4 after 8h and could be a beneficial carrier for fragile drugs.
TPU, Acetic Acid Plasma, EDC/NHS Grafting, Hybrid Hydrogel
To cite this article
Jiunn-An Pan, Hsuan-Liang Liu, Ko-Shao Chen, Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug, International Journal of Biomedical Materials Research. Vol. 7, No. 1, 2019, pp. 16-23. doi: 10.11648/j.ijbmr.20190701.13
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This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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