Science Journal of Analytical Chemistry

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Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction

Received: 27 August 2015    Accepted: 07 September 2015    Published: 16 September 2015
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Abstract

A green method was established for the mutual determination of the drug trifluoperazine hydrochloride (TFPH) and vanadium (V) in real samples by coupling the cloud point extraction with UV-Vis spectrophotometry. The method was based on the formation of the colored V (V)-TFPH complex in acidic medium followed the extraction of the complex by using the surfactant Triton X-114 as an extracting medium. The surfactant-rich phase extracted was dissolved in a small volume of solvent and both the drug TFPH and V (V) ions determined by spectrophotometry at maximum absorption wavelength of 476 nm. Most parameters which impact on the extraction efficiency and detection for both target analytes were optimized. Under the optimum conditions established, the preconcentration factor was found to be of 50 fold making Beer’s law obeyed in the concentration range of 2-80 μg mL-1 (r = 0.9999) for the determination of TFPH and 0.5-10 μg mL-1 (r = 0.9995) for vanadium (V), giving the detection limits of 1.21 and 0.113 μg mL-1 respectively. The mean recovery percentage of 98.94±2.19 % (in blood serum) and 99.43±1.40 (in tap water); the precision (RSD %) ranged between 0.48-3.40 % and 0.45-1.49 were obtained for TFPH and V (V) ions respectively. The proposed method was employed for the determination of TFPH in pharmaceuticals and the spiked serum samples, while a V (V) ion was determined in black pepper samples.

DOI 10.11648/j.sjac.20150305.14
Published in Science Journal of Analytical Chemistry (Volume 3, Issue 5, September 2015)
Page(s) 61-70
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Trifluoperazine Hydrochloride, Vanadium (V) Ions, Hydrophobic Complex, Cloud Point Extraction, Vis - Spectrophotometry

References
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Author Information
  • Department of Chemistry, College of Science for Women, University of Baghdad, Jadiyriah, Baghdad, Iraq

  • Department of Chemistry, College of Science for Women, University of Baghdad, Jadiyriah, Baghdad, Iraq

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    Zuhair A-A. Khammas, Rana Abbas Rashid. (2015). Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction. Science Journal of Analytical Chemistry, 3(5), 61-70. https://doi.org/10.11648/j.sjac.20150305.14

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    Zuhair A-A. Khammas; Rana Abbas Rashid. Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction. Sci. J. Anal. Chem. 2015, 3(5), 61-70. doi: 10.11648/j.sjac.20150305.14

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    Zuhair A-A. Khammas, Rana Abbas Rashid. Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction. Sci J Anal Chem. 2015;3(5):61-70. doi: 10.11648/j.sjac.20150305.14

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  • @article{10.11648/j.sjac.20150305.14,
      author = {Zuhair A-A. Khammas and Rana Abbas Rashid},
      title = {Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction},
      journal = {Science Journal of Analytical Chemistry},
      volume = {3},
      number = {5},
      pages = {61-70},
      doi = {10.11648/j.sjac.20150305.14},
      url = {https://doi.org/10.11648/j.sjac.20150305.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.sjac.20150305.14},
      abstract = {A green method was established for the mutual determination of the drug trifluoperazine hydrochloride (TFPH) and vanadium (V) in real samples by coupling the cloud point extraction with UV-Vis spectrophotometry. The method was based on the formation of the colored V (V)-TFPH complex in acidic medium followed the extraction of the complex by using the surfactant Triton X-114 as an extracting medium. The surfactant-rich phase extracted was dissolved in a small volume of solvent and both the drug TFPH and V (V) ions determined by spectrophotometry at maximum absorption wavelength of 476 nm. Most parameters which impact on the extraction efficiency and detection for both target analytes were optimized. Under the optimum conditions established, the preconcentration factor was found to be of 50 fold making Beer’s law obeyed in the concentration range of 2-80 μg mL-1 (r = 0.9999) for the determination of TFPH and 0.5-10 μg mL-1 (r = 0.9995) for vanadium (V), giving the detection limits of 1.21 and 0.113 μg mL-1 respectively. The mean recovery percentage of 98.94±2.19 % (in blood serum) and 99.43±1.40 (in tap water); the precision (RSD %) ranged between 0.48-3.40 % and 0.45-1.49 were obtained for TFPH and V (V) ions respectively. The proposed method was employed for the determination of TFPH in pharmaceuticals and the spiked serum samples, while a V (V) ion was determined in black pepper samples.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction
    AU  - Zuhair A-A. Khammas
    AU  - Rana Abbas Rashid
    Y1  - 2015/09/16
    PY  - 2015
    N1  - https://doi.org/10.11648/j.sjac.20150305.14
    DO  - 10.11648/j.sjac.20150305.14
    T2  - Science Journal of Analytical Chemistry
    JF  - Science Journal of Analytical Chemistry
    JO  - Science Journal of Analytical Chemistry
    SP  - 61
    EP  - 70
    PB  - Science Publishing Group
    SN  - 2376-8053
    UR  - https://doi.org/10.11648/j.sjac.20150305.14
    AB  - A green method was established for the mutual determination of the drug trifluoperazine hydrochloride (TFPH) and vanadium (V) in real samples by coupling the cloud point extraction with UV-Vis spectrophotometry. The method was based on the formation of the colored V (V)-TFPH complex in acidic medium followed the extraction of the complex by using the surfactant Triton X-114 as an extracting medium. The surfactant-rich phase extracted was dissolved in a small volume of solvent and both the drug TFPH and V (V) ions determined by spectrophotometry at maximum absorption wavelength of 476 nm. Most parameters which impact on the extraction efficiency and detection for both target analytes were optimized. Under the optimum conditions established, the preconcentration factor was found to be of 50 fold making Beer’s law obeyed in the concentration range of 2-80 μg mL-1 (r = 0.9999) for the determination of TFPH and 0.5-10 μg mL-1 (r = 0.9995) for vanadium (V), giving the detection limits of 1.21 and 0.113 μg mL-1 respectively. The mean recovery percentage of 98.94±2.19 % (in blood serum) and 99.43±1.40 (in tap water); the precision (RSD %) ranged between 0.48-3.40 % and 0.45-1.49 were obtained for TFPH and V (V) ions respectively. The proposed method was employed for the determination of TFPH in pharmaceuticals and the spiked serum samples, while a V (V) ion was determined in black pepper samples.
    VL  - 3
    IS  - 5
    ER  - 

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