Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction
A green method was established for the mutual determination of the drug trifluoperazine hydrochloride (TFPH) and vanadium (V) in real samples by coupling the cloud point extraction with UV-Vis spectrophotometry. The method was based on the formation of the colored V (V)-TFPH complex in acidic medium followed the extraction of the complex by using the surfactant Triton X-114 as an extracting medium. The surfactant-rich phase extracted was dissolved in a small volume of solvent and both the drug TFPH and V (V) ions determined by spectrophotometry at maximum absorption wavelength of 476 nm. Most parameters which impact on the extraction efficiency and detection for both target analytes were optimized. Under the optimum conditions established, the preconcentration factor was found to be of 50 fold making Beer’s law obeyed in the concentration range of 2-80 μg mL-1 (r = 0.9999) for the determination of TFPH and 0.5-10 μg mL-1 (r = 0.9995) for vanadium (V), giving the detection limits of 1.21 and 0.113 μg mL-1 respectively. The mean recovery percentage of 98.94±2.19 % (in blood serum) and 99.43±1.40 (in tap water); the precision (RSD %) ranged between 0.48-3.40 % and 0.45-1.49 were obtained for TFPH and V (V) ions respectively. The proposed method was employed for the determination of TFPH in pharmaceuticals and the spiked serum samples, while a V (V) ion was determined in black pepper samples.
Zuhair A-A. Khammas,
Rana Abbas Rashid,
Mutual Determination of Trifluoperazine Hydrochloride and Vanadium (V) Ions in Real Matrices by Visible Spectrophotometry After Cloud Point Extraction, Science Journal of Analytical Chemistry.
Vol. 3, No. 5,
2015, pp. 61-70.
Z. A-A. Khammas, and N. S. Mundir, “Cloud point extraction spectrophotometric method for mutual determination of Norfloxacin and Iron (III) in human serum and drug formulations,” Chem. Sci. Transactions, 4(2), pp. 483-497, 2015.
J. Karpinska, B. Starczweska, and H. Puzanowska-Tarasiewicz” Analytical properties of and 10-disubstituted phenothiazine derivatives,” Anal. Sci., 129, pp. 161–170, 1996.
C. A. Howard, “Pharmaceutical dosage forms and drug delivery systems,” 5th edn, pp. 51 and 196. Lee and Fibiger publisher, London (1990).
A. Q. Waleed Z. A-A. Khammas, A. S. Al-Ayash, and F. Jasim, “An indirect atomic absorption spectrophotometric determination of trifluoperazine hydrochloride in pharmaceuticals,” Arab J. Sci. Eng., 36, pp.553–563, 2011.
A. K. Hassan, S. T. Ameen, B. Saad, and S. M. Al-Aragi,” Potentiometric sensors for the determination of trifluoperazine hydrochloride in pharmaceutical preparations,” Anal. Sci., 25(11), pp.1295-1299, 2009.
D. Sharma, A. Shrivastava1, D. Duggal, and A. Patel,” Stability Indicating RP-HPLC method for the estimation of trifluoperazine hydrochloride as API and estimation in tablet dosage forms”, International Journal of Pharmaceutical Quality Assurance,” 2(2), pp. 38-41, 2010.
S. K. Patel, and N. J. Patel,” Simultaneous RP-HPLC estimation of trifluoperazine hydrochloride and chlordiazepoxide in tablet dosage form,” Indian J Pharm Sci., 71(5), pp. 545–547, 2009.
Manoj, C. Imran, S., Sarika, D. and Avinash, K.,” RP-HPLC method for simultaneous estimation of benzhexol hydrochloride and trifluoperazine hydrochloride in their combined dosage form,” J. Pharm. Res., 3(7), pp. 1616, 2010.
P. Shetti and A. Venkatachalam A, “Stability indicating HPLC method for simultaneous quantification of trihexyphenidyl hydrochloride, trifluoperazine hydrochloride and chlorpromazine. E-J Chem., 7(1), pp. S299-S313, 2010.
M. Jameel, H. A. Taufeeq and A. K. Tarik, “Simultaneous determination of fluphenazine, trifluoperazine, and prochloroperazine in pharmaceutical preparations by HPLC method,” J. Int. Environ. Appl. and Sci., 7 (3), pp. 503- 510, 2012.
S. Pattanayak, and Y. Ash Rani, “A novel RP-HPLC method development and validation for simultaneous estimation of trifluoperazine and isopropamide in tablet dosage form,” International Journal of Pharmaceutical Sciences and Drug Research, 7(1) pp. 105-109, 2015.
D. Navya sri, T. Ramamohan Reddy, A. Ajitha, and V. Uma Maheshwara Rao,” Method development and validation for the simultaneous estimation of trifluoperazine and isopropamide in tablet dosage form by RP-HPLC,” International Journal of Pharmaceutical Research & Analysis, 4 (8), pp. 449-455, 2014.
S. V. Parvataneni, and P. J. Nagarjuna,” Development and validation for the simultaneous determination of trifluoperazine hydrochloride and trihexyphebidyl hydrochgloride in a solid oral dosage form by RP-HPLC”, World Journal of Pharmacy and pharmaceutical sciences, 3(10), pp. 1021-1031, 2014.
A. M. Attaran, N. Mohammadi, M. Javanbakht and B. Akbari-Adergani,” Molecularly imprinted solid-phase extraction for selective trace analysis of trifluoperazine”, J.Chromatogr. Sci., 52(7), pp. 730-738, 2013.
P. Shetti, and A. Venkatachalam,” LC-MS/MS determination of trihexaphenydyl HCl, trifluoperazine HCl and chlorpromazine HCl from blood plasma,” J. Pharm. Biomed. Sci., 9(7), pp. 1-10, 2011.
M. C. Sharma, and C. Shama,” Developmentt and validation of densitometry estimation of trifluoperazine hydrochloride in dosage form”, American-Eurasian Journal of Toxicological Sciences, 3(2), pp. 101-104, 2011.
C. M. Bhaskar Reddy, G. V. Subba Reddy, and N. Ananda Kumar Reddy,” Development and validation of U V spectrophotometric method for determination of trifluoperazine hydrochloride in bulk and pharmaceutical dosage form,” International Journal of Scientific and Research Publications, 2( 8), pp. 1-5, 2012.
M. E. M. Hassouna, A. M. Adawi, and E. A. Ali,” Extractive spectrophotometric determination of chlorpromazine and trifluoperazine hydrochloride in pharmaceutical preparations,” Egyptian Journal of Forensic Sciences, 2(2), pp. 62-68, 2012.
R. B. Saudagar,” Spectrophotometric determination of chlordiazepoxide and trifluoperazine hydrochloride from combined dosage form,” Indian J Pharm. sci. 69(2), pp. 149-152, 2007.
M. A. Karimi, M. M. Ardakani, R. Behjatmanesh-Ardakani, M. R. H. Nezhad, and H. Amiryan,” Individual and simultaneous determinations of phenothiazine drugs using PCR, PLS and (OSC)–PLS multivariate calibration methods,” J. Serb. Chem. Soc. 73 (2), pp. 233–247, 2008.
H. D. Revanasiddappa, and T. N. Kiran Kumar,” Rapid spectrophotometric determination of chromium with trifluoperazine hydrochloride”, Chem. Anal. (Warsaw), 47, pp. 311- 313, 2002.
R. H. Devanasiddappa, and T. N. Kiran Kumar,” A simple and rapid spectrophotometric determination of thallium (III) with trifluoperazine hydrochloride”, Anal. Sci., 18 (10), pp. 1131-11355, 2002.
H. Puzanowska-Tarasiewicz, J. Karpínska, and L. Kúzmicka,” Analytical applications of reactions of iron (III) and hexacyanoferrate (III) with 2, 10-disubstituted phenothiazines,” Int. J. Anal. Chem., 2009, pp.1–8, 2009.
M. Tarasiewicz, H. Puzanowska-Tarasiewicz, W. Misiuk, A. Kojło, A. Grudniewska, andB. Starczewska, “Analytical applications of the reactions of 2-and 10-disubstituted phenothiazines with some metal ions,” Chem. Anal., 44, pp.137–155, 1999.
R. Liasko, T. A. Kabanos, S. Karkabounas, M. Malamas, A. J. Tasiopoulas, D. Stefanou, P. Collery, and A. Evangelou, “Beneficial effects of a vanadium complex with cysteine, administered at low doses on benzo (alpha) pyrene-induced leiomyosarcomas in Wistar rats,” Anticancer Res.,18, pp.3609- 3613, 1998.
B. Venugopal, and T. D. Luckey,” Metal Toxicity in mammals,” Plenum Press, New York, 220.1979.
R. J. Cassella, E. P. Oliveira, and O. I. B. Magalhaes,” Direct determination of vanadium in high saline produced waters from offshore petroleum exploration by electrothermal atomic absorption spectrometry,” Talanta, 69, pp. 48- 54, 2006.
W. Wu, S.-H. Qian, M. Xiao, G.-Q. Huang, and H. Chen, H., “Preconcentration of vanadium (V) on cross linked chitosan and determination by graphite furnace atomic absorption spectrometry,” Wuhan University Journal of Natural Science, 7, pp. 222-226, 2002.
Y. Nir-El, and N. Lavi,” Determination of vanadium in the presence of aluminium by neutron activation analysis,“ Journal of Radioanalytical Chemistry, 55(1), pp. 125-130, 1980.
R. Cornelis, J. Versieck, L. Mees, J. Hoste, and F. Barbier,” Determination of vanadium in human serum by neutron activation analysis”, Journal of Radioanalytical Chemistry, 55(1), pp. 35-43, 1980.
A. A. Al-gadi, and H. M. Al-swaidana “Determination of vanadium in Saudi Arabian crude oil by inductively coupled plasma - mass spectrometry (ICP/MS),” Analytical Letters, 23(9), pp. 1757-1764, 1990.
H. Liu, and S.-J. Jiang,” Determination of vanadium in water samples by reaction cell inductively coupled plasma quadrupole mass spectrometry,” J. Anal. Atom. Spectrom, 17(5), pp. 556-559, 2002.
V. Dupont, Y. Auger, C. Jeandel, and M. Wartel,”Determination of vanadium in seawater by inductively coupled plasma atomic emission spectrometry using chelating resin column preconcentration,” Anal. Chem., 63 (5), pp.520–522, 1991.
E. M. Sedykh, L. N. Bannykh, G. S. Korobeinik, and N. P. Starshinova,” Determination of nickel and vanadium in crude oils by electrothermal atomic absorption spectrometry and inductively coupled plasma atomic emission spectroscopy after mineralization in an autoclave,” Inorganic Materials, 47(14), pp. 1539-1543, 2011.
Y. Okamoto, H. Murata, M. Yamamoto, and T. Kumamaru,” Determination of vanadium and titanium in steel by inductively coupled plasma atomic emission spectrometry with modified use of a tungsten boat furnace atomizer for atomic absorption spectrometry,” Anal. Chim. Acta, 239, pp. 139–143, 1990.
I. Aydin, F. Aydin, E. Kilinc, and C. Hamamci,” Detemination of vanadium in Turkish asphaltites,” Oil Shale, 27(4), pp. 331–338, 2010.
S. Girousi, I. Gherghi, A. Voulgaropoulos and I. Stratis, “Voltammetric determination of vanadium by using 1, 10-phenanthroline as a complexing agent,” International Journal of Environmental Analytical Chemistry, 75, pp.83-91 1999.
Z. A. A. Khammas, Z. T. Ibrahim1 and K. J. Al-adilee,” Two-steps cloud point extraction spectrophotomtric method for separation preconcentration and determination of V (IV) and V (V) ions in real samples using laboratory-made organic reagents,” International Research Journal of Pure and Applied Chemistry, 8(1), pp. 33-48, 2015.
J. L. Manzoori, and G. Karim-Nezhad,” Development of a cloud point extraction and preconcentration method for Cd and Ni prior to flame atomic absorption spectrometric determination,” Anal. Chim. Acta, 521, pp. 173–177, 2004.
S. Brewer, “Solving problems in analytical chemistry” John Wiley and Sons, USA, pp.289-299, 1980.
W. F. El-Hawary, and F. K. Al-Gethami,” Mutual spectrophotometric determination of moxifloxacin drug and iron(III) by formation of a complex compound “Eur, Chem. Bull., 2,pp. 22-27, 2013.
López-García, I., Vinas, P., Romero-Romero, R. and Manuel Hernández-Córdoba, M.,” Ion-exchange preconcentration and determination of vanadium in milk samples by electrothermal atomic absorption spectrometry”, Talanta, 78, pp. 1458–1463, 2009.