Determination of Quinine Clearance in Chronic Renal Failure During Haemodialysis
Science Journal of Analytical Chemistry
Volume 4, Issue 3, May 2016, Pages: 26-29
Received: Apr. 6, 2016; Accepted: Apr. 18, 2016; Published: May 3, 2016
Views 3167      Downloads 105
Authors
Christophe N’cho Amin, Department of Analytical Chemistry, General Chemistry and Inorganic Chemistry, Faculty of Pharmaceutical and Biological Sciences, University of Félix Houphouët-Boigny, Abidjan, Côte d’Ivoire
Philippe André Sawa Kpaibé, Department of Analytical Chemistry, General Chemistry and Inorganic Chemistry, Faculty of Pharmaceutical and Biological Sciences, University of Félix Houphouët-Boigny, Abidjan, Côte d’Ivoire
Nicaise François Bony, Department of Analytical Chemistry, General Chemistry and Inorganic Chemistry, Faculty of Pharmaceutical and Biological Sciences, University of Félix Houphouët-Boigny, Abidjan, Côte d’Ivoire
Gildas Komenan Gbassi, Department of Analytical Chemistry, General Chemistry and Inorganic Chemistry, Faculty of Pharmaceutical and Biological Sciences, University of Félix Houphouët-Boigny, Abidjan, Côte d’Ivoire
Michèle Aké, Department of Analytical Chemistry, General Chemistry and Inorganic Chemistry, Faculty of Pharmaceutical and Biological Sciences, University of Félix Houphouët-Boigny, Abidjan, Côte d’Ivoire
Apollinaire Gnionsahé, Hemodialysis Centre, University Hospital of Cocody, Abidjan, Côte d’Ivoire
Eugène Atindehou, Department of Analytical Chemistry, General Chemistry and Inorganic Chemistry, Faculty of Pharmaceutical and Biological Sciences, University of Félix Houphouët-Boigny, Abidjan, Côte d’Ivoire
Article Tools
Follow on us
Abstract
Hemodialysis is a method that used to achieve the extracorporeal removal of waste products such as creatinine and urea and free water from the blood when the kidneys are in a state of renal failure. However, this treatment may reduce the effectiveness of certain drugs. It is necessary to study the dialysance of quinine, a drug used in first intention for the treatment of severe malaria due to the fragility of uremic patients and the presence of malaria in endemic areas. This study has been conducted at the hemodialysis center of SAMU (Service d’Aide Médicale d’Urgence) in Abidjan Cocody. Twenty one (21) subjects with chronic renal failure aged of 24 to 50 years were enrolled. Two groups of subjects were formed. Each patient of the first group (9 subjects) received per person one tablet of 500 mg of quinine base (single dose) before the hemodialysis started. The second group (12 subjects) received in perfusion 5% glucose solution (250 mL) containing 10 mg.kg-1 of quinine base during 4 hours. The perfusion system and the hemodialysis system were conducted simultaneously. The concentrations of quinine in the tablet, the perfusion solution and the human blood were determined by a validated high performance liquid chromatography method. Quinine content in tablet and perfusion solution was in agreement with the manufacturer's specifications. The clearance of quinine was 23.67 mL.min-1. It appeared of this study that quinine fraction extracted did not require dose adjustment.
Keywords
HPLC, Antimalarial, Quinine, Hemodialysis, Chronic Renal Failure
To cite this article
Christophe N’cho Amin, Philippe André Sawa Kpaibé, Nicaise François Bony, Gildas Komenan Gbassi, Michèle Aké, Apollinaire Gnionsahé, Eugène Atindehou, Determination of Quinine Clearance in Chronic Renal Failure During Haemodialysis, Science Journal of Analytical Chemistry. Vol. 4, No. 3, 2016, pp. 26-29. doi: 10.11648/j.sjac.20160403.12
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
B. Ouattara, O. Kra, H. Yao, K. Kadjo, E. K. Niamkey, Particularités de l’insuffisance rénale chronique chez des patients adultes noirs hospitalisés dans le service de médecine interne du CHU de Treichville, Néphrol. & Thér. 7 (2011) 531-534.
[2]
D. A. Gnionsahé, W. M. Tia, P. N. A. Coulibaly, D. A. Lagou, C. Ackoundou-N’guessan, M. A. Moudachirou, Circonstances de démarrage de la dialyse en Afrique : expérience d’un hôpital public en Côte d’Ivoire, Rev. Int. Sc. Méd. 16 (2014) 44-46.
[3]
World Health Organization, Severe falciparum malaria, Trans. R. Soc.Trop. Med. Hyg. 94 (2000) supplement 1.
[4]
Ministère chargé de la santé en Côte d’Ivoire, Programme National de lutte contre le Paludisme (2004) 1-33.
[5]
L. Roy, M. Leblanc, P. Bannon, J-P. Villeneuve, Quinine pharmacokinetics in chronic hemodialysis patients, Br. J. Clin. Pharmacol. 52 (2002) 604-609.
[6]
V. F. Samanidou, E. N. Evaggelopoulou, I. N. Papadoyannis, Simultaneous determination of quinine and chloroquine anti-malarial agents in pharmaceuticals and biological fluids by HPLC and fluorescence detection, J. Pharm. Biomed. Anal. 38 (2005) 21-28.
[7]
A. M. Sharma, F. Keller, M. Boeckh, J. Heitz, K. Borner, Quinine dosage in severe malaria with renal failure necessitating hemodialysis, Eur. J. Clin. Pharmacol. 36 (1989) 535-536.
[8]
D. V. McCalley, Analysis of the Cinchona al-kaloids by high-performance liquid chromatography and other separation techniques, J. Chromatogr. A 967 (2002) 1-19.
[9]
S. Ahuja, Chromatography and separation science, Amsterdam; Boston: Academic Press, 2003.
[10]
K. Sukontason, J. Karbwang, W. Rimchala, T. Tin, K. Na-Bangchang, V. Banmairuroi, D. Bunnag, Plasma quinine concentrations in falciparum malaria with acute renal failure, Trop. Med. Int. Health 1 (1996) 236-242.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186