Science Journal of Analytical Chemistry

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Standardisation Process of Saye, a Traditional Polyherbal Formulation Remedy for Malaria: Physico-chemical Analysis and Phytochemical Investigation

Received: 18 February 2020    Accepted: 03 March 2020    Published: 10 March 2020
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Abstract

The use of herbal drugs for primary care is nowadays central to the global health system. In developing countries, it meets both economic and socio-cultural requirements. However, this increase about the use of herbal medicines has led to various forms of abuses related to factors that are generally extrinsic to the drug, such as incorrect botanical identification, falsification, fungal or bacterial contamination, etc. The need for the standardization of herbal drugs is more than ever important for the viability of phytotherapy. This study focuses on saye, a mixture of three plants including the root of Cochlospermum planchonii; the whole plant of Phyllanthus amarus and the leaves of Cassia alata. This traditional polyherbal formulation that we intend to promote is used in Burkina Faso as a herbal tea to treat malaria. In this present study, the aim is to control the quality and standardization of the saye and its different components in order to produce an antimalarial phytomedicine. More precisely, we present here, the phytochemical composition and physico-chemical study of the mixture and the vegetable raw materials. In this study, we are particularly concerned with the study of organoleptic properties, moisture content, total ash content, successive extraction yields, fingerprinting by thin layer chromatography, phytochemical screening and total flavonoids content. To evaluate the content of flavonoids selected as chemical bioactive marker, we used a method of spectrophotometric assay. The phytochemical study established fingerprints, identified the main secondary metabolites and determined the total flavonoid content in a selective extract of the saye. The physico-chemical analysis provided satisfactory results on the main indices, such as moisture content, total ash, heavy metals, etc. These results indicate a good treatment of plant raw materials and will certainly be used for the standardization of the drug and its quality control for future clinical studies.

DOI 10.11648/j.sjac.20200801.16
Published in Science Journal of Analytical Chemistry (Volume 8, Issue 1, March 2020)
Page(s) 33-40
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Saye, Cochlospermum Planchonii, Phyllanthus Amarus, Cassia Alata, Standardization, Antimalarial

References
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Author Information
  • Department of Medicine, Traditional Pharmacopoeia and Pharmacy, Research Institute for Health Sciences (MEPHATRA-PH /IRSS), Ouagadougou, Burkina Faso; Molecular Chemistry and Materials Laboratory (LCMM)/Organic Chemistry and Phytochemistry Team (ECOP), University Joseph KI-ZERBO, Ouagadougou, Burkina Faso

  • Organic Chemistry and Reactivity Laboratory, University Joseph KI-ZERBO, Ouagadougou, Burkina Faso

  • Department of Medicine, Traditional Pharmacopoeia and Pharmacy, Research Institute for Health Sciences (MEPHATRA-PH /IRSS), Ouagadougou, Burkina Faso

  • Department of Medicine, Traditional Pharmacopoeia and Pharmacy, Research Institute for Health Sciences (MEPHATRA-PH /IRSS), Ouagadougou, Burkina Faso

  • Department of Medicine, Traditional Pharmacopoeia and Pharmacy, Research Institute for Health Sciences (MEPHATRA-PH /IRSS), Ouagadougou, Burkina Faso

  • Department of Medicine, Traditional Pharmacopoeia and Pharmacy, Research Institute for Health Sciences (MEPHATRA-PH /IRSS), Ouagadougou, Burkina Faso

  • Department of Medicine, Traditional Pharmacopoeia and Pharmacy, Research Institute for Health Sciences (MEPHATRA-PH /IRSS), Ouagadougou, Burkina Faso

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    Jules Yoda, Jean Claude Ouedraogo, Salfo Ouedraogo, Maminata Traore-Coulibaly, Felix Kini, et al. (2020). Standardisation Process of Saye, a Traditional Polyherbal Formulation Remedy for Malaria: Physico-chemical Analysis and Phytochemical Investigation. Science Journal of Analytical Chemistry, 8(1), 33-40. https://doi.org/10.11648/j.sjac.20200801.16

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    ACS Style

    Jules Yoda; Jean Claude Ouedraogo; Salfo Ouedraogo; Maminata Traore-Coulibaly; Felix Kini, et al. Standardisation Process of Saye, a Traditional Polyherbal Formulation Remedy for Malaria: Physico-chemical Analysis and Phytochemical Investigation. Sci. J. Anal. Chem. 2020, 8(1), 33-40. doi: 10.11648/j.sjac.20200801.16

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    AMA Style

    Jules Yoda, Jean Claude Ouedraogo, Salfo Ouedraogo, Maminata Traore-Coulibaly, Felix Kini, et al. Standardisation Process of Saye, a Traditional Polyherbal Formulation Remedy for Malaria: Physico-chemical Analysis and Phytochemical Investigation. Sci J Anal Chem. 2020;8(1):33-40. doi: 10.11648/j.sjac.20200801.16

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  • @article{10.11648/j.sjac.20200801.16,
      author = {Jules Yoda and Jean Claude Ouedraogo and Salfo Ouedraogo and Maminata Traore-Coulibaly and Felix Kini and Marius Lompo and Sylvin Ouedraogo},
      title = {Standardisation Process of Saye, a Traditional Polyherbal Formulation Remedy for Malaria: Physico-chemical Analysis and Phytochemical Investigation},
      journal = {Science Journal of Analytical Chemistry},
      volume = {8},
      number = {1},
      pages = {33-40},
      doi = {10.11648/j.sjac.20200801.16},
      url = {https://doi.org/10.11648/j.sjac.20200801.16},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.sjac.20200801.16},
      abstract = {The use of herbal drugs for primary care is nowadays central to the global health system. In developing countries, it meets both economic and socio-cultural requirements. However, this increase about the use of herbal medicines has led to various forms of abuses related to factors that are generally extrinsic to the drug, such as incorrect botanical identification, falsification, fungal or bacterial contamination, etc. The need for the standardization of herbal drugs is more than ever important for the viability of phytotherapy. This study focuses on saye, a mixture of three plants including the root of Cochlospermum planchonii; the whole plant of Phyllanthus amarus and the leaves of Cassia alata. This traditional polyherbal formulation that we intend to promote is used in Burkina Faso as a herbal tea to treat malaria. In this present study, the aim is to control the quality and standardization of the saye and its different components in order to produce an antimalarial phytomedicine. More precisely, we present here, the phytochemical composition and physico-chemical study of the mixture and the vegetable raw materials. In this study, we are particularly concerned with the study of organoleptic properties, moisture content, total ash content, successive extraction yields, fingerprinting by thin layer chromatography, phytochemical screening and total flavonoids content. To evaluate the content of flavonoids selected as chemical bioactive marker, we used a method of spectrophotometric assay. The phytochemical study established fingerprints, identified the main secondary metabolites and determined the total flavonoid content in a selective extract of the saye. The physico-chemical analysis provided satisfactory results on the main indices, such as moisture content, total ash, heavy metals, etc. These results indicate a good treatment of plant raw materials and will certainly be used for the standardization of the drug and its quality control for future clinical studies.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Standardisation Process of Saye, a Traditional Polyherbal Formulation Remedy for Malaria: Physico-chemical Analysis and Phytochemical Investigation
    AU  - Jules Yoda
    AU  - Jean Claude Ouedraogo
    AU  - Salfo Ouedraogo
    AU  - Maminata Traore-Coulibaly
    AU  - Felix Kini
    AU  - Marius Lompo
    AU  - Sylvin Ouedraogo
    Y1  - 2020/03/10
    PY  - 2020
    N1  - https://doi.org/10.11648/j.sjac.20200801.16
    DO  - 10.11648/j.sjac.20200801.16
    T2  - Science Journal of Analytical Chemistry
    JF  - Science Journal of Analytical Chemistry
    JO  - Science Journal of Analytical Chemistry
    SP  - 33
    EP  - 40
    PB  - Science Publishing Group
    SN  - 2376-8053
    UR  - https://doi.org/10.11648/j.sjac.20200801.16
    AB  - The use of herbal drugs for primary care is nowadays central to the global health system. In developing countries, it meets both economic and socio-cultural requirements. However, this increase about the use of herbal medicines has led to various forms of abuses related to factors that are generally extrinsic to the drug, such as incorrect botanical identification, falsification, fungal or bacterial contamination, etc. The need for the standardization of herbal drugs is more than ever important for the viability of phytotherapy. This study focuses on saye, a mixture of three plants including the root of Cochlospermum planchonii; the whole plant of Phyllanthus amarus and the leaves of Cassia alata. This traditional polyherbal formulation that we intend to promote is used in Burkina Faso as a herbal tea to treat malaria. In this present study, the aim is to control the quality and standardization of the saye and its different components in order to produce an antimalarial phytomedicine. More precisely, we present here, the phytochemical composition and physico-chemical study of the mixture and the vegetable raw materials. In this study, we are particularly concerned with the study of organoleptic properties, moisture content, total ash content, successive extraction yields, fingerprinting by thin layer chromatography, phytochemical screening and total flavonoids content. To evaluate the content of flavonoids selected as chemical bioactive marker, we used a method of spectrophotometric assay. The phytochemical study established fingerprints, identified the main secondary metabolites and determined the total flavonoid content in a selective extract of the saye. The physico-chemical analysis provided satisfactory results on the main indices, such as moisture content, total ash, heavy metals, etc. These results indicate a good treatment of plant raw materials and will certainly be used for the standardization of the drug and its quality control for future clinical studies.
    VL  - 8
    IS  - 1
    ER  - 

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