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Effects of Moringa oleifera Biochemical Constituents on Kidney, Liver and Brain of Wister Rats
Science Journal of Analytical Chemistry
Volume 8, Issue 4, December 2020, Pages: 128-132
Received: Mar. 18, 2020; Accepted: Apr. 2, 2020; Published: Dec. 31, 2020
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Authors
Ibrahim Maina Hassan, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Bashir Saidu, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Ja’afaru Abdullahi Ishaq, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Ashiru Dahiru, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Nafisat Abdulazeez, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Halima Ibrahim Yusuf, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Dahiru Hafiz Karofi, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Nicholas Nathaniel Pilau, Department of Veterinary Medicine, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Adamu Abdul Abubakar, Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
Bulama Ibrahim, Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria
Adama Musa Abdullahi, Department of Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria
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Abstract
Medicinal plant have evolved over the centuries as essential parts of African civilization and are widely recognized today as representing its rich cultural and scientific heritage. The increasing demand for Medicinal plant products has renewed interest in the pharmaceutical industry in the production of herbal health care formulations, herbal-based cosmetic products, and herbal nutritional supplements. Thus, in addition to serving medical and cultural functions, Medicinal plants in Africa have economic importance. Global and national markets have been growing for medicinal herbs, and significant economic gains are being realized through the sale of medicinal plant products. The aim of this particular investigation was to observe the effects of Moringa oleifera 80% methanol leaf extract on the histological architecture of kidney, liver and brain tissues. Fifteen (15) rats were randomLy divided into three (3) with five rats per group. Rats were exposed to 2000 mg/kg, 1000 mg/kg and 500 mg/kg of Moringa oleifera extract per os (p.o) along with the control group that was placed on commercial diet. There was no observed mortality in all experimental rats but there is deleterious effect in brain, liver and kidney in those that were exposed to higher doses especially the 2000 mg/kg. It’s therefore concluded that higher dose of Moringa oleifera is toxic while moderate doses is safe to most vital organs especially brain, liver and kidney. There is need for further investigation to identify the phytochemical constituents that are responsible for the toxic effects.
Keywords
Brain, Extract, Kidney, Liver, Moringa oleifera, Phytochemical Constituents, Rats
To cite this article
Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, Halima Ibrahim Yusuf, Dahiru Hafiz Karofi, Nicholas Nathaniel Pilau, Adamu Abdul Abubakar, Bulama Ibrahim, Adama Musa Abdullahi, Effects of Moringa oleifera Biochemical Constituents on Kidney, Liver and Brain of Wister Rats, Science Journal of Analytical Chemistry. Vol. 8, No. 4, 2020, pp. 128-132. doi: 10.11648/j.sjac.20200804.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Pilotos, J., Ibrahim, K. A., Mowa, C. N., & Opata, M. M., Moringa oleifera treatment increases Tbet expression in CD4+ T cells and remediates immune defects of malnutrition in Plasmodium chabaudi-infected mice. Malaria Journal 2020. 19 (1): p. 62.
[2]
Mumtaz, S., Ali, S., Khan, R., Shakir, H. A., Tahir, H. M., Mumtaz, S., & Andleeb, S., Therapeutic role of garlic and vitamins C and E against toxicity induced by lead on various organs. Environmental Science and Pollution Research 2020: p. 1-12.
[3]
Prabu, S. L., Umamaheswari, A., & Puratchikody, A., Phytopharmacological potential of the natural gift Moringa oleifera Lam and its therapeutic application: An overview. Asian Pacific Journal of Tropical Medicine 2019. 12 (11): p. 485.
[4]
El-Hadary, A. E., & Ramadan, M. F., Antioxidant traits and protective impact of Moringa oleifera leaf extract against diclofenac sodium-induced liver toxicity in rats. Journal of food biochemistry 2019. 43 (2): p. e12704.
[5]
Abo Rabia, N., & Khalaf, G., Histological study on the possible protective role of Moringa Oleifera leaves extract on Paracetamol induced liver damage in adult male albino rats. Egyptian Journal of Histology 2019. 42 (3): p. 712-729.
[6]
Dhakad, A. K., Ikram, M., Sharma, S., Khan, S., Pandey, V. V., & Singh, A., Biological, nutritional, and therapeutic significance of Moringa oleifera Lam. Phytotherapy Research 2019. 33 (11): p. 2870-2903.
[7]
Muzumbukilwa, W. T., Kadima, M. G., Nlooto, M., & Owira, P. M. O., Mapping the evidence of hepatoprotective properties of Moringa oleifera from sub-Saharan African countries: a systematic review protocol. Systematic reviews 2019. 8 (1): p. 1-6.
[8]
Owojuyigbe, O. S., Firempong, C. K., Larbie, C., Komlaga, G., & Emikpe, B. O., Hepatoprotective Potential of Hura crepitans L.: A Review of Ethnomedical, Phytochemical and Pharmacological Studies. Journal of Complementary and Alternative Medical Research 2020: p. 1-10.
[9]
Gbankoto, A., Sindete, M., Adjagba, M., Sangare, M. M., Attakpa, E. S., & Awede, B., Antihypertensive effects of Moringa oleifera leaf extract Lam.(Moringaceae) in NG-nitro-L-arginine-methyl ester-induced hypertensive rats. National Journal of Physiology, Pharmacy and Pharmacology 2019. 9 (12): p. 1257-1266.
[10]
Das, A., Nair, M. S., & Peter, S. D., Computer-Aided Histopathological Image Analysis Techniques for Automated Nuclear Atypia Scoring of Breast Cancer: a Review. Journal of Digital Imaging 2020: p. 1-31.
[11]
Simond, A. E., Houde, M., Lesage, V., Michaud, R., Zbinden, D., & Verreault, J. Associations between organohalogen exposure and thyroid-and steroid-related gene responses in St. Lawrence Estuary belugas and minke whales. Marine pollution bulletin 2019. 145: p. 174-184.
[12]
Yoo, J. J., Kim, W., Kim, M. Y., Jun, D. W., Kim, S. G., Yeon, J. E.,... & Sohn, J. H., Recent research trends and updates on nonalcoholic fatty liver disease. Clinical and molecular hepatology 2019. 25 (1): p. 1.
[13]
Karak, P., Biological activities of flavonoids: An overview.. IJPSR. 2019. 3: p. 1567-1574.
[14]
Auwalu, G., Dingwoke, E. J., Amin, A. F., Nwobodo, N. N., & Lawan, M. M., Comparative Free Radical Scavenging Efficacy of Leaves Extract of Moringa Oleifera and Petals Extract of Hibiscus Sabdariffa. Pharmacognosy Journal, 2019. 11 (6).
[15]
Anderson, C. J., Bredvik, K., Burstein, S. R., Davis, C., Meadows, S. M., Dash, J.,... & Piersigilli, A., ALS/FTD mutant CHCHD10 mice reveal a tissue-specific toxic gain-of-function and mitochondrial stress response. Acta neuropathologica 2019. 138 (1): p. 103-121.
[16]
Al-Okaily, B. N., Effect of Pomegranate Seed Oil against Hepatotoxicity-Induced by Sodium Fluoride in Adult Female Rats (Part II). The Iraqi Journal of Veterinary Medicine 2019. 43 (1): p. 102-112.
[17]
Wang, H. H., Portincasa, P., & Wang, D. Q. H., Update on the molecular mechanisms underlying the effect of cholecystokinin and cholecystokinin-1 receptor on the formation of cholesterol gallstones. Current medicinal chemistry 2019. 26 (19): p. 3407-3423.
[18]
Miyauchi, T., Uchida, Y., Kadono, K., Hirao, H., Kawasoe, J., Watanabe, T.,... & Uemoto, S., Up-regulation of FOXO1 and reduced inflammation by β-hydroxybutyric acid are essential diet restriction benefits against liver injury. Proceedings of the National Academy of Sciences 2019. 116 (27): p. 13533-13542.
[19]
Chong, L. H., Ng, C., Li, H., Tian, E. F., Ananthanarayanan, A., McMillian, M., & Toh, Y. C., Hepatic Bioactivation of Skin-Sensitizing Drugs to Immunogenic Reactive Metabolites. ACS omega 2019. 4 (9): p. 13902-13912.
[20]
Attwa, M. W., Kadi, A. A., & Abdelhameed, A. S., Phase I metabolic profiling and unexpected reactive metabolites in human liver microsome incubations of X-376 using LC-MS/MS: bioactivation pathway elucidation and in silico toxicity studies of its metabolites. RSC Advances, 2020. 10 (9): p. 5412-5427.
[21]
Elmore, S. A., Kavari, S. L., Hoenerhoff, M. J., Mahler, B., Scott, B. E., Yabe, K., & Seely, J. C., Histology Atlas of the Developing Mouse Urinary System With Emphasis on Prenatal Days E10. 5-E18. 5. Toxicologic pathology 2019. 47 (7): p. 865-886.
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