Kinetic Parameters Survey for Manufacture of Pralidoxime

Daniel Antonio Shimizu Kitagawa; Sabrina Teixeira Martinez; Erick Braga Ferrao Galante; Tanos Celmar Costa Franca

doi:doi:10.11648/j.ajche.20150303.12

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Kinetic Parameters Survey for Manufacture of Pralidoxime

Daniel Antonio Shimizu Kitagawa, Sabrina Teixeira Martinez, Erick Braga Ferrao Galante, Tanos Celmar Costa Franca

Published in American Journal of Chemical Engineering (Volume 3, Issue 3)

Received: 18 June 2015 Accepted: 29 June 2015 Published: 14 July 2015

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Abstract

Chemical agents represent a serious threat to the modern world. Among them, they stand out nerve agents because of its high lethality and dangerousness. They are typically organophosphate compounds, which act by inhibiting acetylcholinesterase, a key enzyme in the transmission of nerve impulses process. There are several forms of treatment for organophosphate poisoning, and pralidoxime (2-PAM) is the drug most used as reactivator of acetylcholinesterase. In this work, we developed the first three steps for the synthesis of 2-PAM, with the objective of obtaining data to calculate the kinetic parameters of these steps. These parameters may be used for the manufacture of 2-PAM in semi-pilot scale. Through the studies conducted it has been found that the preparation of the oxime has very rapid kinetics.

Published in	American Journal of Chemical Engineering (Volume 3, Issue 3)
DOI	10.11648/j.ajche.20150303.12
Page(s)	39-51
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Chemicals warfare agents, Organophosphates compounds, Acetylcholinesterase, Oximes, Pralidoxime

References

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APA Style

Daniel Antonio Shimizu Kitagawa, Sabrina Teixeira Martinez, Erick Braga Ferrao Galante, Tanos Celmar Costa Franca. (2015). Kinetic Parameters Survey for Manufacture of Pralidoxime. American Journal of Chemical Engineering, 3(3), 39-51. https://doi.org/10.11648/j.ajche.20150303.12

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ACS Style

Daniel Antonio Shimizu Kitagawa; Sabrina Teixeira Martinez; Erick Braga Ferrao Galante; Tanos Celmar Costa Franca. Kinetic Parameters Survey for Manufacture of Pralidoxime. Am. J. Chem. Eng. 2015, 3(3), 39-51. doi: 10.11648/j.ajche.20150303.12

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AMA Style

Daniel Antonio Shimizu Kitagawa, Sabrina Teixeira Martinez, Erick Braga Ferrao Galante, Tanos Celmar Costa Franca. Kinetic Parameters Survey for Manufacture of Pralidoxime. Am J Chem Eng. 2015;3(3):39-51. doi: 10.11648/j.ajche.20150303.12

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@article{10.11648/j.ajche.20150303.12,
  author = {Daniel Antonio Shimizu Kitagawa and Sabrina Teixeira Martinez and Erick Braga Ferrao Galante and Tanos Celmar Costa Franca},
  title = {Kinetic Parameters Survey for Manufacture of Pralidoxime},
  journal = {American Journal of Chemical Engineering},
  volume = {3},
  number = {3},
  pages = {39-51},
  doi = {10.11648/j.ajche.20150303.12},
  url = {https://doi.org/10.11648/j.ajche.20150303.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajche.20150303.12},
  abstract = {Chemical agents represent a serious threat to the modern world. Among them, they stand out nerve agents because of its high lethality and dangerousness. They are typically organophosphate compounds, which act by inhibiting acetylcholinesterase, a key enzyme in the transmission of nerve impulses process. There are several forms of treatment for organophosphate poisoning, and pralidoxime (2-PAM) is the drug most used as reactivator of acetylcholinesterase. In this work, we developed the first three steps for the synthesis of 2-PAM, with the objective of obtaining data to calculate the kinetic parameters of these steps. These parameters may be used for the manufacture of 2-PAM in semi-pilot scale. Through the studies conducted it has been found that the preparation of the oxime has very rapid kinetics.},
 year = {2015}
}

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TY  - JOUR
T1  - Kinetic Parameters Survey for Manufacture of Pralidoxime
AU  - Daniel Antonio Shimizu Kitagawa
AU  - Sabrina Teixeira Martinez
AU  - Erick Braga Ferrao Galante
AU  - Tanos Celmar Costa Franca
Y1  - 2015/07/14
PY  - 2015
N1  - https://doi.org/10.11648/j.ajche.20150303.12
DO  - 10.11648/j.ajche.20150303.12
T2  - American Journal of Chemical Engineering
JF  - American Journal of Chemical Engineering
JO  - American Journal of Chemical Engineering
SP  - 39
EP  - 51
PB  - Science Publishing Group
SN  - 2330-8613
UR  - https://doi.org/10.11648/j.ajche.20150303.12
AB  - Chemical agents represent a serious threat to the modern world. Among them, they stand out nerve agents because of its high lethality and dangerousness. They are typically organophosphate compounds, which act by inhibiting acetylcholinesterase, a key enzyme in the transmission of nerve impulses process. There are several forms of treatment for organophosphate poisoning, and pralidoxime (2-PAM) is the drug most used as reactivator of acetylcholinesterase. In this work, we developed the first three steps for the synthesis of 2-PAM, with the objective of obtaining data to calculate the kinetic parameters of these steps. These parameters may be used for the manufacture of 2-PAM in semi-pilot scale. Through the studies conducted it has been found that the preparation of the oxime has very rapid kinetics.
VL  - 3
IS  - 3
ER  -

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Author Information

Daniel Antonio Shimizu Kitagawa

Division of Chemical, Biological and Nuclear Defense, Technological Centre of Army, CTEx, Rio de Janeiro, Brazil
Sabrina Teixeira Martinez

Chemical Engineering Department, Military Institute of Engineering, IME, Rio de Janeiro, Brazil; Organic Chemistry Department, Chemical Institute, Federal University of Rio de Janeiro, UFRJ, Rio de Janeiro, Brazil
Erick Braga Ferrao Galante

Chemical Engineering Department, Military Institute of Engineering, IME, Rio de Janeiro, Brazil
Tanos Celmar Costa Franca

Chemical Engineering Department, Military Institute of Engineering, IME, Rio de Janeiro, Brazil; Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, Czech Republic

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Plain Text BibTeX RIS

APA Style

Daniel Antonio Shimizu Kitagawa, Sabrina Teixeira Martinez, Erick Braga Ferrao Galante, Tanos Celmar Costa Franca. (2015). Kinetic Parameters Survey for Manufacture of Pralidoxime. American Journal of Chemical Engineering, 3(3), 39-51. https://doi.org/10.11648/j.ajche.20150303.12

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ACS Style

Daniel Antonio Shimizu Kitagawa; Sabrina Teixeira Martinez; Erick Braga Ferrao Galante; Tanos Celmar Costa Franca. Kinetic Parameters Survey for Manufacture of Pralidoxime. Am. J. Chem. Eng. 2015, 3(3), 39-51. doi: 10.11648/j.ajche.20150303.12

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AMA Style

Daniel Antonio Shimizu Kitagawa, Sabrina Teixeira Martinez, Erick Braga Ferrao Galante, Tanos Celmar Costa Franca. Kinetic Parameters Survey for Manufacture of Pralidoxime. Am J Chem Eng. 2015;3(3):39-51. doi: 10.11648/j.ajche.20150303.12

Copy | Download

@article{10.11648/j.ajche.20150303.12,
  author = {Daniel Antonio Shimizu Kitagawa and Sabrina Teixeira Martinez and Erick Braga Ferrao Galante and Tanos Celmar Costa Franca},
  title = {Kinetic Parameters Survey for Manufacture of Pralidoxime},
  journal = {American Journal of Chemical Engineering},
  volume = {3},
  number = {3},
  pages = {39-51},
  doi = {10.11648/j.ajche.20150303.12},
  url = {https://doi.org/10.11648/j.ajche.20150303.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajche.20150303.12},
  abstract = {Chemical agents represent a serious threat to the modern world. Among them, they stand out nerve agents because of its high lethality and dangerousness. They are typically organophosphate compounds, which act by inhibiting acetylcholinesterase, a key enzyme in the transmission of nerve impulses process. There are several forms of treatment for organophosphate poisoning, and pralidoxime (2-PAM) is the drug most used as reactivator of acetylcholinesterase. In this work, we developed the first three steps for the synthesis of 2-PAM, with the objective of obtaining data to calculate the kinetic parameters of these steps. These parameters may be used for the manufacture of 2-PAM in semi-pilot scale. Through the studies conducted it has been found that the preparation of the oxime has very rapid kinetics.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Kinetic Parameters Survey for Manufacture of Pralidoxime
AU  - Daniel Antonio Shimizu Kitagawa
AU  - Sabrina Teixeira Martinez
AU  - Erick Braga Ferrao Galante
AU  - Tanos Celmar Costa Franca
Y1  - 2015/07/14
PY  - 2015
N1  - https://doi.org/10.11648/j.ajche.20150303.12
DO  - 10.11648/j.ajche.20150303.12
T2  - American Journal of Chemical Engineering
JF  - American Journal of Chemical Engineering
JO  - American Journal of Chemical Engineering
SP  - 39
EP  - 51
PB  - Science Publishing Group
SN  - 2330-8613
UR  - https://doi.org/10.11648/j.ajche.20150303.12
AB  - Chemical agents represent a serious threat to the modern world. Among them, they stand out nerve agents because of its high lethality and dangerousness. They are typically organophosphate compounds, which act by inhibiting acetylcholinesterase, a key enzyme in the transmission of nerve impulses process. There are several forms of treatment for organophosphate poisoning, and pralidoxime (2-PAM) is the drug most used as reactivator of acetylcholinesterase. In this work, we developed the first three steps for the synthesis of 2-PAM, with the objective of obtaining data to calculate the kinetic parameters of these steps. These parameters may be used for the manufacture of 2-PAM in semi-pilot scale. Through the studies conducted it has been found that the preparation of the oxime has very rapid kinetics.
VL  - 3
IS  - 3
ER  -

Copy | Download