Palladium(II)-Catalyzed Oxidation of Pyrimidine Derivative by Hexacyanoferrate(III) in Aqueous Alkaline Medium: A Kinetic Study
American Journal of Chemical Engineering
Volume 4, Issue 2, March 2016, Pages: 38-45
Received: Mar. 10, 2016; Accepted: Mar. 18, 2016; Published: Mar. 31, 2016
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Authors
Ahmed Fawzy, Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia; Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt
Ishaq Zaafarany, Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia
Fahd Turkistani, Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia
Jabir Alfahemi, Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia
Moataz Morad, Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia
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Abstract
The of kinetics of oxidation of a pyrimidine derivative, N,N-dimethyl-N’-(pyrimidin-2-yl) formamidine (Pym-F), by hexacyanoferrate(III) (HCF) was studied in aqueous alkaline medium in the presence of palladium(II) catalyst. The reaction did not proceed in the absence of Pd(II) catalyst. The progress of the catalyzed reaction was followed spectrophotometrically. The reaction showed a first order kinetics in both [HCF] and [Pd(II)], and less than unit orders with respect to both [Pym-F] and [OH-]. Increasing ionic strength and dielectric constant of the medium increased the reaction rate. A mechanistic scheme for the catalyzed oxidation reaction has been proposed. The final oxidation products are identified as 2-aminopyrimidine, dimethylamine and carbon dioxide. The rate law expression associated with the reaction mechanism is derived and the reaction constants involved in the different steps of the mechanism are calculated. The activation parameters with respect to the rate-determining step have been computed and discussed.
Keywords
Pyrimidine Derivative, Oxidation, Kinetics, Mechanism, Palladium(III), Hexacyanoferrate(III)
To cite this article
Ahmed Fawzy, Ishaq Zaafarany, Fahd Turkistani, Jabir Alfahemi, Moataz Morad, Palladium(II)-Catalyzed Oxidation of Pyrimidine Derivative by Hexacyanoferrate(III) in Aqueous Alkaline Medium: A Kinetic Study, American Journal of Chemical Engineering. Vol. 4, No. 2, 2016, pp. 38-45. doi: 10.11648/j.ajche.20160402.12
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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