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Reactive Chromatography: A Review of Process Technology
American Journal of Chemical Engineering
Volume 7, Issue 1, January 2019, Pages: 1-6
Received: Dec. 6, 2018; Accepted: Jan. 29, 2019; Published: Feb. 21, 2019
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Rajendra Bhaskar Bhandare, Department of Chemical Engineering, Babasaheb Ambedkar Technological University, Lonere, India
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Chemical Industries are primarily intended for conversion of raw materials into desired products. It develops new products for human lives. The challenge for chemical companies is to cut their costs. The chemical industries have high rate of technological change. Chemical industries use separate processes for converting raw material into product. Now day’s the technology that is adopted is reactive separation. In this technology, the emphasis is given on combining separate units in one single unit. Advantageous of this technology is like reducing energy use, increase efficiency etc. Reactive separation uses different techniques like Reactive Chromatography, Reactive Distillation and Reactive Extraction, Reactive Membrane Separation, Reactive Crystallization. Out of this, Reactive chromatography is a attractive alternative since it employs differences in adsorption - desorption of chemical reagents on external solid phase, which can also act as catalyst. It is possible to obtain high purity of product from this process, also downstream purification is reduced or even eliminated. Fixed bed reactor or simulated bed reactors are mainly used for this purpose. Many researchers have studied reactive chromatography. This review is focused in development in reactive chromatography processes.
Reactive Separation, Reactive Chromatography, Fixed Bed Chromatography Reactor, Simulated Bed Chromatography Reactor
To cite this article
Rajendra Bhaskar Bhandare, Reactive Chromatography: A Review of Process Technology, American Journal of Chemical Engineering. Vol. 7, No. 1, 2019, pp. 1-6. doi: 10.11648/j.ajche.20190701.11
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
M. Malone, R. Huss, M. Doherty, “Green chemical engineering aspects of reactive Distillation”, Environmental Science & Technology, vol. 37, 2003, pp. 5325 – 5329.
S. Kulprathipanja, (2002) S. Ed., Reactive separation process, Taylor and Francis, New york, USA.
G. Agrawal, J. Oh, B. Sreedhar, S. Tie, M. Donaldson, T. Frank, A. Schultz, A. Bommarius, Y. Kawajiri, “Optimization of reactive simulated moving bed systems with modulation of feed concentration for production of glycol ether ester”, Journal of Chromatography A, vol.1360, 2014, pp. 196 – 208.
O. Jungmin, B. Sreedhar, M. Donaldson, T. Frank, “Transesterification of propylene glycol methyl ether in chromatographic reactors using anion exchange resin as a catalyst”, Journal of ChromatographyA, vol. 466, 2016, pp. 84 – 95.
Z. Erlangung des akademischen Grades,“Analysis of Heterogeneously Catalyzed Ester Hydrolysis Reactions in a Fixed-Bed Chromatographic Reactor”, PhD Thesis, 2007.
F. Lode, M. Houmard, C. Migliorini, M. Mazzotti, M. Morbidelli, “Continuous reactive chromatography”, Chemical Engineering Science,, vol. 56, 2001, pp.269 – 291.
K. Deshmukh, V. Ganyi, S. Mahajani, “Esterification of Butyl Cellosolve with Acetic Acid using Ion Exchange Resin in Fixed Bed Chromatographic Reactors”, International Journal of Chemical Reactor Engineering, vol. 7, 2009, pp.1 - 27.
E. Reed, J. Dranoff, “Ion exchange resin catalysis of sucrose inversion in fixed beds”, Industrial and Engineering Chemistry fundamentals, vol.3, no. 4, 1964, pp. 304 – 307.
M. Mazzotti, B. Neri, D. Gelosa, and M. Morbidelli, “Dynamics of a Chromatographic Reactor: Esterification Catalyzed by Acidic Resins”, Industrial & Engineering Chemistry Reserch, vol. 36, 1997, pp. 3163 – 3172.
D. Gelosa, M. Ramaioli, and G. Valente, “Chromatographic Reactors: Esterification of Glycerol with Acetic Acid Using Acidic Polymeric Resins”, Industrial Engineeering Chemistry Reserch, vol. 42, 2003, pp. 6536 – 6544.
T. Vu, S. Morgenstern, S. Gruner, and A. Kienle, “Analysis of Ester Hydrolysis Reactions in a Chromatographic Reactor Using Equilibrium Theory and a Rate Model”, Industrial & Engineering Chemistry Reserch, vol. 44, 2005, pp. 9565 – 9574.
G. Strohleina, Y. Assunçao, N. Dubeb, A. Bardowc, M. Mazzottid, M. Morbidellia, “Esterification of acrylic acid with methanol by reactive chromatography: Experiments and Simulations”, Chemical Engineering Science, vol. 61, 2006, pp.5296 – 5306.
S. Ali, “Kinetics of Catalytic Esterification of Propionic Acid with Different Alcohols over Amberlyst 15”, International Journal of Chemical Kinetics, vol. 41, no.6, 2008, pp. 432 – 448.
V. Gyani and S. Mahajani, “Reactive Chromatography for the Synthesis of 2 - Ethylhexyl Acetate”, Seperation Science and Technology, vol. 43, 2008, pp. 2245 – 2268.
C. Pereira, M. Zabka, V., Silva, A. Rodrigues, “A novel process for the ethyl lactate synthesis in a simulated moving bed reactor”, Chemical Engineering Science, vol. 64, 2009, pp. 3301 – 3310.
S. Dakdouki, D. Villemin, N. bar, “Solid‐Phase Reactive Chromatography (SPRC): A New Methodology for Wittig and Horner - Emmons Reactions on a Column under Microwave Irradiation”, Europan Journal of Orgnic Chemistry, vol. 2010, no.2, pp. 333 - 337.
D. Patel and. B. Saha, “Esterification reactions of acetic acid and n - hexanol were studied in batch and continuous chromatographic reactors in the presence of a gelular ion-exchange resin catalyst”, Industrial & Engineering Chemistry Reserch, vol. 51, no.37, 2012, pp. 11965 – 11974.
B. Reddy, V. Gyani, and S. Mahajani, “Simulated Moving Bed Reactor for the Synthesis of 2-Ethylhexyl Acetate. Part II: Simulation Based Design”, Industrial & Engineering Chemistry Reserch, vol. 53, 2014, pp. 15811 – 15823.
V. Gyani, B. Reddy, R. Bhat and S. Mahajani, “Simulated Moving Bed Reactor for the Synthesis of 2 - Ethylhexyl Acetate. Part I: Experiments and Simulations,” Industrial & Engineering Chemistry Reserch, vol. 53, 2014, pp. 15811 - 15823.
J. Oh. G. Agrawala, B. Sreedhara, M. Donaldsonb, A. Schultzb, T. Frank, A. Bommariusa, Y. Kawajiria, “Conversion Improvement for Catalytic Synthesis of Propylene Glycol Methyl Ether Acetate by Reactive Chromatography: Experiments and Parameter Estimation”, Chemical Engineering Journal, vol. 259, 2014, pp. 397 - 409.
P. Ghodke, V. Ch, A. Ganesha, S. Mahajani, “Stabilization of pyrolysis oil: Comparison of reactive distillation and reactive chromatography”, Chemical Engineering Processing:Process Intensification, vol. 95, 2015, pp. 327 - 338.
S. Bibi, S. Qamar, M. Seidel, “Irreversible and reversible reactive chromatography: analytical solutions and moment analysis for rectangular pulse injections”, Journal of Chromatography A, vol. 1385, 2015, pp. 49 – 62.
Yanhui Ma, Yanjun Ma, “Mathematical Simulation of Multiphase Reactive Chromatography Process”, Chemical Engineering Transactions, vol. 62, 2017, pp. 1099 – 1104.
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