Green Synthesis of Tin Based Nano Medicine: Assessment of Microstructure and Surface Property
American Journal of Nano Research and Applications
Volume 2, Issue 4, July 2014, Pages: 75-83
Received: Jun. 4, 2014;
Accepted: Jul. 22, 2014;
Published: Aug. 10, 2014
Views 3161 Downloads 250
Sethumadhavan Sudhaparimala, Department of Chemistry, Ethiraj College for Women (Autonomous), Chennai – 8, India
Arumugam Gnanamani A., Microbiology Division, Central Leather Research Institute (CSIR, New Delhi), Adyar, Chennai 20, India
Asit Baran Mandal, Chemical Laboratory, Central Leather Research Institute, Adyar, Chennai (Madras) 600020, India
The present study is about an eco-friendly and cost effective method of using five potent plant extracts and sunlight as the reaction medium and grinding as a nano technique to prepare nano composite of tin (IV) oxide from tin metal. The equivalent preparation is widely used as a drug formulation in the treatment of spectrum of infectious diseases. The intensive grinding and calcinations with the plant material lead to the formation of nano crystallite with a tetragonal phase with an average crystallite size of 27nm. The elements Ca, P, Na, Mg and Fe at the microscopic level identified at the surface of the nano crystallite by the X – ray Photo Electron Spectroscopy showed the uniqueness of the synthesis. The formation of spherical crystallites with good distribution of pores was indicated by the electron microscopic images and adsorption studies. The presence of oxygen deficiency arising due to nonstoichiometry in the crystal lattice was evident from the Electron paramagnetic Resonance study. The free radical equivalent of DPPH radical calculated for the final stage sample was suggestive of its anti-oxidant property and hence it’s biological activity. The overall research study provided an alternative route of preparing nontoxic nano tin (IV) oxide composite with good biological activity apart from its already proven catalytic and sensor applications.
Arumugam Gnanamani A.,
Asit Baran Mandal,
Green Synthesis of Tin Based Nano Medicine: Assessment of Microstructure and Surface Property, American Journal of Nano Research and Applications.
Vol. 2, No. 4,
2014, pp. 75-83.
Radha Narayanan, “Synthesis of green nanocatalysts and industrially important green reactions,” Green Chemistry Lett. and Rev. 5(4) : 707-725,2012..
S.R.Bonde, D.P.Rathod , A.P. Ingle, R.B. Ade, A.K. Gade , M.K. Rai, “.Murraya koenigii-mediated synthesis of silver nanoparticles and its activity against three human pathogenic bacteria, “ Nano Sci methods, 1(1)1:25-36, 2012.
K.S.Kavitha, S.Baker, D.Rakshith, H.U. Kavitha, B.P. Harini, & S.Satish, “Plants as Green Source towards Synthesis of Nanoparticles”. Int. Res.J. Biological Sci, 2(6), 66-7, 2013.
Feng Gu, Shu Fen Wang, Meng Kai Lu, Guang Jun Zhou, Dong Xu, Duo Rong Yuan, “Photoluminiscence properties of SnO2 Nano particles Synthesised by Sol – Gel Method, “ J.Phy. Chem. B 108, 8119-8123, 2004.
J.Trigilio, T.E.Antoine, I. Paulowicz , Y.K.Mishra, R.Adelung, “ Tin Oxide Nanowires Suppress Herpes Simplex Virus-1 Entry and Cell-to-Cell Membrane Fusion”. PLoS ONE 7(10), 2012.
S.S.Parimala, A.Gnanamani , A.B. Mandal, “ Bulk and surface properties of tin based herbal drug during its preparation: fingerprinting of the active pharmaceutical constituent,” Int. J. Pharm. Sci. and Res. 3(4): 1037-1042, 2012.
S.Sudhaparimala, A. Gnanamani, A.B.Mandal, “Egg shell powder as the Precursor for the Synthesis of nano crystalline Calcium Stannate (CaSnO3) with Orthorhombic Perovskite structure: Exploration on Phase, Morphology and Antioxidant property”. Che Sci Rev Lett , 2(5), 267–277, 2012.
K.M. Nadkarni, “Indian Materia Medica,”. 3th edition. Mumbai: Popular Prakashan Ltd., 1062-1063, 1976.
Julio César Escalona-Arranz, Renato Pérez-Rosés, Irina Licea Jiménez, Jesús Rodríguez-Amado, Humberto Argota-Coello, Javier Cañizares-Lay, Humberto, “Chemical constituents of Tamarindus indica L. LEAVES,” J. Revista Cubana de Quimica,Morris-Quevedo, Gustavo Sierra-González XXII : 3, 2010.
Hassan Abdalla Almahy and Nafisa Ibrahim Alhassan, “Studies on the Chemical Constituents of the Leaves of Ficus Bengalensis and Their Antimicrobial Activity, “ J.Sc. Tech ـ 12(1), 2011.
Arumugam Kathirvel and Venugopal Sujatha, “Phytochemical analysis and antioxidant activity of barringtonia acutangula (l) gaertn. Leaves,” Int J Pharm Pharm Sci, 4(2), 277-281, 2012.
Neha Pandey, Dushyant Barve , “Phytochemical and Pharmacological Review on Annona squamosa Linn International Journal of Research in Pharmaceutical and Biomedical Sciences, “ Vol. 2(4) Oct - Dec 2011.
A.K. Chudiwal, D.P. Jain, R.S Somani, "Alpinia galanga Willd – An overview on phyto-pharmacological properties,” Indian J Nat Prod Resour. 1(2), 143-149,2010.
K.Nakamato, “Infrared and Raman spectra of inorganic and coordination compounds, “ New York: John Wiley and Sons, 1, 978-226, 1986.
M. Ristic, I.M., Popovic, S.Music, “Dependence of nano crystalline SnO2particle size on synthesis route”. J Non Crystalline Solid, 303, 270-280, 2002.
S.Chacko, N.S.Philip, K.G.Gophandran, P.Koshy, V.K. Vaidyan, “Nanostructural and surface morphological evolution of chemically sprayed SnO2 thin films,“ Appl. Surf. Sci. 254:2179-2186, 2008.
ICDD. Powder diffraction file, edited by S. Kabekkodu, International Centre for Diffraction Data, Newtown square, Pennsylvania, 21-1250 Tetragonal crystallographic system Space group P4 /mnm (136), 2009.
S.Sudhaparimala, Christina Selin, A.Gnanamani, A.B.Mandal, “Synthesis and characterisation of nano crystalline tin (IV) oxide from tin (II) chloride using combined microwave and traditional calcinations procedures”. J Cur Res. in Che.4: 60-67, 2012.
V.Thangadurai, A.K.Shukla, J.Gopalakrishnan, “Proton conduction in layered perovskite oxides,” Solid State Ionics , 73 (1-2) : 9-14, 1994. D.L.Ningthoujam, V.Sudarsan, H.K.Poswal, S.K.Kulshreshtha, S.M.Sharma, B.Bhushan, M.D.Sastry,” Nature of V n+ ions in SnO2 : EPR and Photoluminescence studies”. Mat Res Bul, 42,1293-1300, 2010.
Gabbott Paul, Principles and applications of thermal analysis. Blackwell Publishing Ltd. 2008.
D.H.Gracias, J. Tien, T.Breen, C. Hsu, G.M. Whitesides, “Forming electrical networks in threedimensions by self – assembly,” Science, 289,1170–1172, 2000.
Mariana Ionita, loan Vorl Branzoi, Laurentiu Popa, “Synthesis, physicochemical characterization, and preliminary molecular modelling studies on SnO2 nanoparticles,” Surf. Inter. Anal. 42, 983-986, 2009.
I.S.Mulla, V.J., Rao, H.S. Soni, S. Badrinarayanan, A.P.B. Sinha, A.P.B, “Electron spectroscopic studies on films of SnO2 and SnO2: Sb”, Surf. Coat Tech. 31, 77 – 88, 1987.
.R.Contreras, H. Sahlin, H, J.A.Frangos, “Titanate biomaterials with enhanced anti inflammatory properties,” J Biomed Mater Res A, 80A, 480-485, 2007.