Hypothetical Formulation to Propel Pico-molecular Medicinal Dust: Application to Total Elevation of Therapeutic Efficiency Compare to Nano Entity
American Journal of Nano Research and Applications
Volume 5, Issue 6, December 2017, Pages: 91-101
Received: Oct. 15, 2017; Accepted: Oct. 25, 2017; Published: Dec. 22, 2017
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Rakesh Das, Department of Pharmaceutical Technology, Bioequivalence Study Center, Jadavpur University, Kolkata, India
Subhendu Chatterjee, Department of Biotechnology, IIT Karagpur, Kharagpur, WB, India
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Ongoing through all the applications of nano medicines through various sources, it has been understand that preparation of polymeric nanoparticle, liposomes, Dendrimers, Solid Lipid Nanoparticle (SLN) and polymeric micelles is useful for Drug delivery system. Also, helpful to repairs the DNA and treatment of many diseases by increase rate of toxin elimination. The nano medicines in various way initiate the proper biotransformation in livers and also give rise to effective pharmacodynamics profiles. It has been discovered that many nano molecules can be converted into picomolecular medicinal dust (pMMD) entities on lowering the molecular weight, reducing the bond length and shortening the molecular length. This (pMMD) is basically useful in respiratory system treatment, Skin targeted penetration and ophthalmic disorders ramification to ensure hypothetical probability to facilitate Pico-molecular dust involvement as medicinal propeller. Because, it acquires the finest position to receptors less than nano receptors, nano enzymes, nano amino acids chain/polymers, nano pores, nano-microelements, DNA and other nano bio-molecules etc., where nano molecular modules are not effectives. The pico dust will acquires its position into the more specified pico-receptors where nano molecules cannot penetrate or lodge. Pico medicine spray could be implicated superficially over the skin surface at high pressure. So, that it get penetrate upto the subcutaneous and intradermal skin layers with 100% inoculation easily. In ophthalmic preparation, the pico-molecular drugs spray will help to open the drainage area stimulating the receptor on the iris edge corner for dilation of path openings and constriction of circular muscles of eye to create pressure for fluid ejaculation.
Nano-Molecular Medicines, Pico-Molecular Medicinal Dust, High Pressure Propeller, Respiratory Treatment, Skin and Ophthalmic Remedies
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Rakesh Das, Subhendu Chatterjee, Hypothetical Formulation to Propel Pico-molecular Medicinal Dust: Application to Total Elevation of Therapeutic Efficiency Compare to Nano Entity, American Journal of Nano Research and Applications. Vol. 5, No. 6, 2017, pp. 91-101. doi: 10.11648/j.nano.20170506.13
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