Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder
American Journal of Applied Chemistry
Volume 2, Issue 6, December 2014, Pages: 96-104
Received: Nov. 12, 2013; Accepted: Nov. 28, 2014; Published: Nov. 27, 2014
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Authors
Xiaoyuan Niu, The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Ying Xu, The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Qiaoling Yang, The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Xiaowen Tang, The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Li Yang, The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Center for Chinese Medical Therapy and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Zhengtao Wang, The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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Abstract
Bile acids as characteristic compounds of human and animal bile are major endogenous products of cholesterol and play very important roles in cholesterol homeostasis, lipid absorption and production of bile flow. At present, bile acids are useful biomarkers and signaling molecules for the diagnosis or treatment of many diseases in clinic. Various analytical methods, from overall to individual, qualitative to quantitative, have been developed for the determination of bile acids in biomedical samples and even bile-based medicinal materials. The most precious and commonly-used bile-based traditional animal medicines are cow-bezoar (CB) and bear bile powder (BBP), which regard bile acids as the main bioactive constituents and have extensive use for treating many diseases since thousands of years ago. However, extensive consumption of CB and BBP make their natural resource scarcity and price valuableness. Currently, artificial, in-vitro cultured substitutes and even worse adulterants or counterfeits mix in the medicine market and they have seriously compromised the therapeutic effects of these two traditional medicines. To guarantee the long-term development of ethnodrugs, many analytical approaches have been utilized in quality control of CB and BBP. In this paper, various analytical methods of bile acids are summarized and compared with each other.
Keywords
Bile Acids, Analytical Methods, Cow-Bezoar, Bear Bile Powder, Quality Control
To cite this article
Xiaoyuan Niu, Ying Xu, Qiaoling Yang, Xiaowen Tang, Li Yang, Zhengtao Wang, Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder, American Journal of Applied Chemistry. Vol. 2, No. 6, 2014, pp. 96-104. doi: 10.11648/j.ajac.20140206.11
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