Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes
International Journal of Ophthalmology & Visual Science
Volume 1, Issue 1, November 2016, Pages: 1-7
Received: Aug. 19, 2016;
Accepted: Aug. 30, 2016;
Published: Sep. 13, 2016
Views 3630 Downloads 133
Elka Popova, Department of Physiology, Medical University of Sofia, Sofia, Bulgaria
Petia Kupenova, Department of Physiology, Medical University of Sofia, Sofia, Bulgaria
It is known that histamine is neurotransmitter of the retinopetal axons that originate from the tuberomamillary nucleus of the posterior hypothalamus, but its role in visual information processing in the retina is not well understood. The aim of this study was to give insight into the significance that histamine has for the distal retina function revealed by electroretinogram (ERG). The effect of 5 M histamine on the intensity – response function of the b-wave (ON response) and d-wave (OFF response) of ERG was investigated in dark adapted perfused frog eyecup preparations. Perfusion with histamine caused a significant enhancement of the amplitude of both the ON and OFF responses over the entire intensity range studied in comparison with corresponding values obtained in the control experiments. The enhancing effect of histamine was more pronounced upon the OFF than ON response in the lower intensity range, where the responses were mediated by rods. The reverse was true for the higher intensity range, where the responses were cone-dominated. The b-wave V – log I function had a steeper slope and narrower dynamic range during histamine treatment. Histamine did not alter significantly the relative sensitivity of the ON response, while it significantly increased the relative sensitivity of the OFF response. The present results clearly demonstrate that histamine has a significant effect on the intensity-response function of frog ERG b- and d-waves. This effect shows some ON/OFF asymmetries in dependence of the photoreceptor input.
Effects of Histamine on the Intensity-Response Function of the Electroretinographic b- and d-Waves in Dark Adapted Frog Eyes, International Journal of Ophthalmology & Visual Science.
Vol. 1, No. 1,
2016, pp. 1-7.
Airaksinen, and P. Panula, “The histaminergic system in the guinea pig central nervous system: an immunocytochemical mapping study using an antiserum against histamine,” J. Comp. Neurol. Vol. 273, pp. 163-186, 1988.
Greferath U, Kambourakis M, Barth C, Fletcher EL, Murphy M. Characterization of histamine projections and their potential cellular targets in the mouse retina. Neuroscience 2009; 158: 932-44.
Gastinger MJ, O'Brien JJ, Larsen NB, Marshak DW. Histamine immunoreactive axons in the macaque retina. Invest Ophthalmol Vis Sci. 1999; 40: 487-95.
Gastinger MJ, Barber AJ, Khin SA, McRill CS, Gardner TW, Marshak DW. Abnormal centrifugal axons in streptozotocin-diabetic rat retinas. Invest Ophthalmol Vis Sci. 2001; 42: 2679-85.
Yu YC, Satoh H, Wu SM, Marshak DW. Histamine enhances voltage-gated potassium currents of ON bipolar cells in macaque retina. Invest Ophthalmol Vis Sci. 2009; 50: 959-65.
Akimov NP, Marshak DW, Frishman LJ, Glickman RD, Yusupov RG. Histamine reduces flash sensitivity of on ganglion cells in the primate retina. Invest Ophthalmol Vis Sci. 2010; 51: 3825-34.
Gastinger MJ, Yusupov RG, Glickman RD, Marshak DW. The effects of histamine on rat and monkey retinal ganglion cells. Vis Neurosci. 2004; 21: 935-43.
Yu Y, Satoh H, Vila A, Wu SM, Marshak DW. Effects of histamine on light responses of amacrine cells in tiger salamander retina. Neurochem Res. 2011; 36: 645-54.
Vila A, Satoh H, Rangel C, Mills SL, Hoshi H, O'Brien J, Marshak DR, Macleish PR., Marshak DW. Histamine receptors of cones and horizontal cells in Old World monkey retinas. J Comp Neurol. 2012; 520: 528-43.
Greferath U, Vessey KA, Jobling AI, Mills SA, Bui BV, He Z, Nag N, Ohtsu H, Fletcher EL. The role of histamine in the retina: studies on the Hdc knockout mouse. PLoS One 2014; 9: e116025.
Popova E, Kupenova P. Effects of histamine on the ON and OFF responses of dark adapted frog electroretinogram. Compt Rend I'Acad Bulg Sci. 2016; 69: 755-60.
Frazão R, McMahon DG, Schunack W, Datta P, Heidelberger R, Marshak DW. Histamine elevates free intracellular calcium in mouse retinal dopaminergic cells via H1-receptors. Invest Ophthalmol Vis Sci. 2011; 52: 3083-88.
Popova E, Kupenova P Effects of dopamine D1 receptor blockade on the intensity-response function of ERG b- and d-waves under different conditions of light adaptation. Vision Res. 2011; 51: 1627-36.
Popova E, Kupenova P. Effects of dopamine receptor blockade on the intensity-response function of ERG b- and d-waves in dark adapted eyes. Vision Res. 2013; 88: 22-29.
Kupenova P, Popova E, Vitanova L. GABAa and GABAc receptor mediated influences on the intensity-response functions of the b- and d-wave in the frog ERG. Vision Res. 2008; 48: 882-92.
Naka KI, Rushton WAH. S-potentials from colour units in the retina of fish (Cyprinidae). J Physiol. 1966; 185: 536–55.
Kupenova TN. An inductive algorithm for smooth approximation of functions. Commun JINR 2011, Dubna: E11-2011-97.
Frishman LJ. Origins of the electroretinogram. In: Heckenlively JR, Arden GB, editors. Principles and Practice of Clinical Electrophysiology of Vision. 2nd ed. London: MIT Press; 2006. p. 139–183.
Frishman LJ. Electrogenesis of the electroretinogram. In: Ryan SJ, Hinton DR, Sadda SR, Schachat AP, Wilkinson CP, Wiedemann P, editors. Retina. 5th ed. Elsevier Health Sciences; 2013, volume 1, p. 177-201.
Weber B, Schlicker E. Modulation of dopamine release in the guinea-pig retina by G (i)- but not by G (s)- or G (q)-protein coupled receptors. Fundam Clin Pharmacol. 2001; 15: 393–400.
Brown RE, Stevens DR, Haas HL. The physiology of brain histamine. Prog Neurobiol. 2001; 63: 637–72.
Weiger T, Stevens DR, Wunder L, Haas HL. Histamine H1 receptors in C6 glial cells are coupled to calcium-dependent potassium channels via release of calcium from internal stores. Naunyn Schmiedebergs Arch. Pharmacol. 1997; 355: 559–65.