A Combined Clinical and Langmuir Film Study of Natural Tear Films
International Journal of Ophthalmology & Visual Science
Volume 2, Issue 1, February 2017, Pages: 5-14
Received: Feb. 2, 2017; Accepted: Feb. 23, 2017; Published: Mar. 9, 2017
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Authors
Ester Guaus, Faculty of Optics and Optometry, Department of Chemical Engineering, Universitat Politècnica de Catalunya, C/ Violinista Vellsolà, Terrassa (Barcelona), Spain
Carla Fàbregas, Faculty of Optics and Optometry, Department of Chemical Engineering, Universitat Politècnica de Catalunya, C/ Violinista Vellsolà, Terrassa (Barcelona), Spain
Miriam Pérez, Faculty of Optics and Optometry, Department of Chemical Engineering, Universitat Politècnica de Catalunya, C/ Violinista Vellsolà, Terrassa (Barcelona), Spain
Juan Torrent-Burgués, Faculty of Optics and Optometry, Department of Chemical Engineering, Universitat Politècnica de Catalunya, C/ Violinista Vellsolà, Terrassa (Barcelona), Spain
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Abstract
The Langmuir technique has been applied to the study of natural tears and the results obtained from surface pressure-area isotherms have been correlated with those of clinical tests (the Schirmer and the TFBUT tests). The population studied only included people aged over 45. Natural tears were collected from Schirmer strips, which were placed in contact with the water subphase of a Langmuir trough for recording the surface pressure-area isotherms. These isotherms have been classified as good or weak according to the characteristics obtained. From the isotherms, characteristic values such as πlimit, CS-1max and πmax were also obtained. The analysis from the Chi-squared test indicates dependence between the Schirmer test and the type of isotherms (P<0.05). In the case of the TFBUT test and the type of isotherms the value of P>0.05 indicates that the independence cannot be discarded with the significance criteria imposed. Working with the same criteria of significance, we obtain moderate or good Pearson correlation coefficients with statistical significance (P<0.05) between the values of the Schirmer test and the πlimit, CS-1max and πmax values. On the other hand, we obtain low Pearson correlation coefficients with no statistical significance (P>0.05) between the values of the TFBUT test and the πlimit, CS-1max and πmax values.
Keywords
Natural Tears, Surface Pressure-Area Isotherm, Elastic Modulus, Schirmer Test, Tear Film Break-Up-Time (TFBUT)
To cite this article
Ester Guaus, Carla Fàbregas, Miriam Pérez, Juan Torrent-Burgués, A Combined Clinical and Langmuir Film Study of Natural Tear Films, International Journal of Ophthalmology & Visual Science. Vol. 2, No. 1, 2017, pp. 5-14. doi: 10.11648/j.ijovs.20170201.13
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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