Clinical Differences Between Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis in Chinese Patients: A Retrospective Comparative Case Series Study

Jun Chen; Wanghua Zhao; Zacharia Ackbarkhan; Jianfeng He; Yi Du

doi:doi:10.11648/j.ijovs.20190401.12

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Clinical Differences Between Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis in Chinese Patients: A Retrospective Comparative Case Series Study

Jun Chen, Wanghua Zhao, Zacharia Ackbarkhan, Jianfeng He, Yi Du

Published in International Journal of Ophthalmology & Visual Science (Volume 4, Issue 1)

Received: 6 January 2019 Accepted: 30 January 2019 Published: 25 February 2019

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Abstract

The aim of this study is to compare the clinical features between nonarteritic anterior ischemic optic neuropathy (NAION) and optic neuritis (ON) in Chinese patients. The clinical features of 23 cases (23 eyes) of NAION and 62 cases (80 eyes) of ON, including their general conditions, manifestations, auxiliary examinations were retrospectively compared. Simultaneous onset of bilateral eye (29.03% vs. 0%, p=0.009) and pain on movement of the eyes (23.75% vs. 0%, p=0.022) were more common in ON patients in comparison to NAION patients. Ocular pain (32.5% vs. 4.35%, p=0.007) was higher in ON patients than that in NAION patients. Optic disc edema (100% vs. 62.5%, p<0.001), peripapillary hemorrhage (47.83% vs. 10%, p<0.001) and peripapillary hard exudates (17.39% vs. 1.25%, p=0.009) in NAION patients were more common compared to ON patients,. During fluorescein angiography, the rates of the partial or whole papillary hypofluorescent in early phase (65.21% vs. 22.86%, p<0.001), peripapillary choroidal filling delay (73.91% vs. 14.29%, p<0.001) and partial papillary hyperfluorescent in later phase (52.17% vs. 25.71%, p=0.019) were higher in NAION patients than those in ON patients. The clinical features of NAION and ON in Chinese patients reveal a surprising overlap and they still have some characteristic clinical features that can be utilized to differentiate the two diseases.

Published in	International Journal of Ophthalmology & Visual Science (Volume 4, Issue 1)
DOI	10.11648/j.ijovs.20190401.12
Page(s)	7-13
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Nonarteritic Anterior Ischemic Optic Neuropathy, Optic Neuritis, Retrospective Study, Chinese Patients, Distinct Features

References

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[17]	Kim MK, Kim US. Analysis of Fundus Photography and Fluorescein Angiography in Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis. Korean J Ophthalmol. 2016; 30(4): 289-94.
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APA Style

Jun Chen, Wanghua Zhao, Zacharia Ackbarkhan, Jianfeng He, Yi Du. (2019). Clinical Differences Between Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis in Chinese Patients: A Retrospective Comparative Case Series Study. International Journal of Ophthalmology & Visual Science, 4(1), 7-13. https://doi.org/10.11648/j.ijovs.20190401.12

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ACS Style

Jun Chen; Wanghua Zhao; Zacharia Ackbarkhan; Jianfeng He; Yi Du. Clinical Differences Between Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis in Chinese Patients: A Retrospective Comparative Case Series Study. Int. J. Ophthalmol. Vis. Sci. 2019, 4(1), 7-13. doi: 10.11648/j.ijovs.20190401.12

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AMA Style

Jun Chen, Wanghua Zhao, Zacharia Ackbarkhan, Jianfeng He, Yi Du. Clinical Differences Between Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis in Chinese Patients: A Retrospective Comparative Case Series Study. Int J Ophthalmol Vis Sci. 2019;4(1):7-13. doi: 10.11648/j.ijovs.20190401.12

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@article{10.11648/j.ijovs.20190401.12,
  author = {Jun Chen and Wanghua Zhao and Zacharia Ackbarkhan and Jianfeng He and Yi Du},
  title = {Clinical Differences Between Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis in Chinese Patients: A Retrospective Comparative Case Series Study},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {4},
  number = {1},
  pages = {7-13},
  doi = {10.11648/j.ijovs.20190401.12},
  url = {https://doi.org/10.11648/j.ijovs.20190401.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20190401.12},
  abstract = {The aim of this study is to compare the clinical features between nonarteritic anterior ischemic optic neuropathy (NAION) and optic neuritis (ON) in Chinese patients. The clinical features of 23 cases (23 eyes) of NAION and 62 cases (80 eyes) of ON, including their general conditions, manifestations, auxiliary examinations were retrospectively compared. Simultaneous onset of bilateral eye (29.03% vs. 0%, p=0.009) and pain on movement of the eyes (23.75% vs. 0%, p=0.022) were more common in ON patients in comparison to NAION patients. Ocular pain (32.5% vs. 4.35%, p=0.007) was higher in ON patients than that in NAION patients. Optic disc edema (100% vs. 62.5%, p<0.001), peripapillary hemorrhage (47.83% vs. 10%, p<0.001) and peripapillary hard exudates (17.39% vs. 1.25%, p=0.009) in NAION patients were more common compared to ON patients,. During fluorescein angiography, the rates of the partial or whole papillary hypofluorescent in early phase (65.21% vs. 22.86%, p<0.001), peripapillary choroidal filling delay (73.91% vs. 14.29%, p<0.001) and partial papillary hyperfluorescent in later phase (52.17% vs. 25.71%, p=0.019) were higher in NAION patients than those in ON patients. The clinical features of NAION and ON in Chinese patients reveal a surprising overlap and they still have some characteristic clinical features that can be utilized to differentiate the two diseases.},
 year = {2019}
}

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TY  - JOUR
T1  - Clinical Differences Between Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis in Chinese Patients: A Retrospective Comparative Case Series Study
AU  - Jun Chen
AU  - Wanghua Zhao
AU  - Zacharia Ackbarkhan
AU  - Jianfeng He
AU  - Yi Du
Y1  - 2019/02/25
PY  - 2019
N1  - https://doi.org/10.11648/j.ijovs.20190401.12
DO  - 10.11648/j.ijovs.20190401.12
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 7
EP  - 13
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20190401.12
AB  - The aim of this study is to compare the clinical features between nonarteritic anterior ischemic optic neuropathy (NAION) and optic neuritis (ON) in Chinese patients. The clinical features of 23 cases (23 eyes) of NAION and 62 cases (80 eyes) of ON, including their general conditions, manifestations, auxiliary examinations were retrospectively compared. Simultaneous onset of bilateral eye (29.03% vs. 0%, p=0.009) and pain on movement of the eyes (23.75% vs. 0%, p=0.022) were more common in ON patients in comparison to NAION patients. Ocular pain (32.5% vs. 4.35%, p=0.007) was higher in ON patients than that in NAION patients. Optic disc edema (100% vs. 62.5%, p<0.001), peripapillary hemorrhage (47.83% vs. 10%, p<0.001) and peripapillary hard exudates (17.39% vs. 1.25%, p=0.009) in NAION patients were more common compared to ON patients,. During fluorescein angiography, the rates of the partial or whole papillary hypofluorescent in early phase (65.21% vs. 22.86%, p<0.001), peripapillary choroidal filling delay (73.91% vs. 14.29%, p<0.001) and partial papillary hyperfluorescent in later phase (52.17% vs. 25.71%, p=0.019) were higher in NAION patients than those in ON patients. The clinical features of NAION and ON in Chinese patients reveal a surprising overlap and they still have some characteristic clinical features that can be utilized to differentiate the two diseases.
VL  - 4
IS  - 1
ER  -

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Author Information

Jun Chen

Department of Ophthalmology, First Affiliated Hospital of Guangxi Medical University, Nanning, China; Department of Ophthalmology, Affiliated Nanping First Hospital of Fujian Medical University, Nanping, China
Wanghua Zhao

Department of Ophthalmology, First Affiliated Hospital of Guangxi Medical University, Nanning, China
Zacharia Ackbarkhan

Department of Ophthalmology, First Affiliated Hospital of Guangxi Medical University, Nanning, China
Jianfeng He

Department of Ophthalmology, First Affiliated Hospital of Guangxi Medical University, Nanning, China
Yi Du

Department of Ophthalmology, First Affiliated Hospital of Guangxi Medical University, Nanning, China

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APA Style

Jun Chen, Wanghua Zhao, Zacharia Ackbarkhan, Jianfeng He, Yi Du. (2019). Clinical Differences Between Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis in Chinese Patients: A Retrospective Comparative Case Series Study. International Journal of Ophthalmology & Visual Science, 4(1), 7-13. https://doi.org/10.11648/j.ijovs.20190401.12

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ACS Style

Jun Chen; Wanghua Zhao; Zacharia Ackbarkhan; Jianfeng He; Yi Du. Clinical Differences Between Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis in Chinese Patients: A Retrospective Comparative Case Series Study. Int. J. Ophthalmol. Vis. Sci. 2019, 4(1), 7-13. doi: 10.11648/j.ijovs.20190401.12

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AMA Style

Jun Chen, Wanghua Zhao, Zacharia Ackbarkhan, Jianfeng He, Yi Du. Clinical Differences Between Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis in Chinese Patients: A Retrospective Comparative Case Series Study. Int J Ophthalmol Vis Sci. 2019;4(1):7-13. doi: 10.11648/j.ijovs.20190401.12

Copy | Download

@article{10.11648/j.ijovs.20190401.12,
  author = {Jun Chen and Wanghua Zhao and Zacharia Ackbarkhan and Jianfeng He and Yi Du},
  title = {Clinical Differences Between Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis in Chinese Patients: A Retrospective Comparative Case Series Study},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {4},
  number = {1},
  pages = {7-13},
  doi = {10.11648/j.ijovs.20190401.12},
  url = {https://doi.org/10.11648/j.ijovs.20190401.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20190401.12},
  abstract = {The aim of this study is to compare the clinical features between nonarteritic anterior ischemic optic neuropathy (NAION) and optic neuritis (ON) in Chinese patients. The clinical features of 23 cases (23 eyes) of NAION and 62 cases (80 eyes) of ON, including their general conditions, manifestations, auxiliary examinations were retrospectively compared. Simultaneous onset of bilateral eye (29.03% vs. 0%, p=0.009) and pain on movement of the eyes (23.75% vs. 0%, p=0.022) were more common in ON patients in comparison to NAION patients. Ocular pain (32.5% vs. 4.35%, p=0.007) was higher in ON patients than that in NAION patients. Optic disc edema (100% vs. 62.5%, p<0.001), peripapillary hemorrhage (47.83% vs. 10%, p<0.001) and peripapillary hard exudates (17.39% vs. 1.25%, p=0.009) in NAION patients were more common compared to ON patients,. During fluorescein angiography, the rates of the partial or whole papillary hypofluorescent in early phase (65.21% vs. 22.86%, p<0.001), peripapillary choroidal filling delay (73.91% vs. 14.29%, p<0.001) and partial papillary hyperfluorescent in later phase (52.17% vs. 25.71%, p=0.019) were higher in NAION patients than those in ON patients. The clinical features of NAION and ON in Chinese patients reveal a surprising overlap and they still have some characteristic clinical features that can be utilized to differentiate the two diseases.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Clinical Differences Between Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis in Chinese Patients: A Retrospective Comparative Case Series Study
AU  - Jun Chen
AU  - Wanghua Zhao
AU  - Zacharia Ackbarkhan
AU  - Jianfeng He
AU  - Yi Du
Y1  - 2019/02/25
PY  - 2019
N1  - https://doi.org/10.11648/j.ijovs.20190401.12
DO  - 10.11648/j.ijovs.20190401.12
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 7
EP  - 13
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20190401.12
AB  - The aim of this study is to compare the clinical features between nonarteritic anterior ischemic optic neuropathy (NAION) and optic neuritis (ON) in Chinese patients. The clinical features of 23 cases (23 eyes) of NAION and 62 cases (80 eyes) of ON, including their general conditions, manifestations, auxiliary examinations were retrospectively compared. Simultaneous onset of bilateral eye (29.03% vs. 0%, p=0.009) and pain on movement of the eyes (23.75% vs. 0%, p=0.022) were more common in ON patients in comparison to NAION patients. Ocular pain (32.5% vs. 4.35%, p=0.007) was higher in ON patients than that in NAION patients. Optic disc edema (100% vs. 62.5%, p<0.001), peripapillary hemorrhage (47.83% vs. 10%, p<0.001) and peripapillary hard exudates (17.39% vs. 1.25%, p=0.009) in NAION patients were more common compared to ON patients,. During fluorescein angiography, the rates of the partial or whole papillary hypofluorescent in early phase (65.21% vs. 22.86%, p<0.001), peripapillary choroidal filling delay (73.91% vs. 14.29%, p<0.001) and partial papillary hyperfluorescent in later phase (52.17% vs. 25.71%, p=0.019) were higher in NAION patients than those in ON patients. The clinical features of NAION and ON in Chinese patients reveal a surprising overlap and they still have some characteristic clinical features that can be utilized to differentiate the two diseases.
VL  - 4
IS  - 1
ER  -

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