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Bilateral Metastases of Colorectal Cancer to the Choroid and Optic Disc

Received: 28 February 2017    Accepted: 22 April 2017    Published: 12 June 2017
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Abstract

Introduction: Metastatic colorectal cancer is highly fatal disease. While metastases are usually found in the thoracic cavity in colorectal cancer, the choroid has been shown to harbor metastases. The retrobuorbital pathway, although rarely, has also demonstrated colorectal metastases. Case report: A 54-year-old male with a one-year history of disseminated colon cancer presented with vision loss in his right eye in October 2013. A choroidal metastasis was found extending from the optic disc toward the fovea, Initial treatment consisted of systemic chemotherapy, supplemented by External Beam Radiation Therapy to the right eye one year after diagnosis. Thirteen months later, the left eye was found to have a choroidal tumor surrounding the disc. The cancer progressed through both local and systemic treatment. Discussion: While the disease progressed through multiple rounds of chemotherapy, external beam radiation therapy was shown to be effective in regressing the tumors. Managing refractory metastatic disease presents unique challenges in properly prioritizing therapeutic routes.

Published in International Journal of Ophthalmology & Visual Science (Volume 2, Issue 3)
DOI 10.11648/j.ijovs.20170203.11
Page(s) 65-68
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Colorectal Cancer, Ocular Metastases, External Beam Radiation Therapy, Optic Disc Tumor

References
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[4] Arepalli, S. et al. “Choroidal Metastases: Origin, Features and Therapy” Indian J Ophthalmol. 63: 122-127. 2015.
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[7] Nelson CC “A Histopathologic Study of 716 Unselected Eyes in Patients with Cancer at the Time of Death” Am J of Ophthalmol 95: 788-793. 1983.
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[9] Shields J. et al. “Metastatic Neoplasms In The Optic Disc: The 1999 Bjerrum Lecture: Part 2”. Arch Ophthalmol. 118: 217-224. 2000.
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[11] Font RL, Ferry, AP. “Carcinoma Metastatic to the Eye and Orbit III. A Clinicopathologic Study Of Cases Metastatic To The Orbit”. Cancer. 28(3): 1326-35. 1976.
[12] Mack H. et al. “Isolated Metastases to the Retina or Optic Nerve” Int. Ophthalmol Clin. 37 (4): 251-260. 1997.
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[18] Rudoler, et al. “Functional Vision is improved in the Majority of Patients Treated with External-Beam Radiotherapy for Choroidal Metastases: A Multi-variate Analysis of 188 patients” Journal of Clinical Oncology. 15(3): 1244-51. 1997.
[19] Tsina EK, et al.“Treatment of Metastatic Tumors of the Choroid With Proton Beam Irradiation” Ophthalmology 112(2): 337-343.
[20] Marchini G, et al. “Stereotactic Radiosurgery of Uveal Melanomas: Preliminary Results with Gamma Knife Treatment” Stereotact Funct Neurogurg 65: 72-79. 1995.
[21] Daftari IK, et al. “A Noninvasive Eye Fixation Monitoring System For Cyberknife Radiotherapy of Choroidal and Orbital Tumors” Med Phys 36: 719-724. 2009.
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[23] Kuo, I. et al. Regression of a Subfoveal Choroidal Metastasis of Colorectal Carcinoma After Intravitreous Bevacizumab Treatment. Archives of Ophthalmology. 126 (9): 1311-1313. 2008.
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  • APA Style

    Caleb Roy Walker, David Alan Reichstein. (2017). Bilateral Metastases of Colorectal Cancer to the Choroid and Optic Disc. International Journal of Ophthalmology & Visual Science, 2(3), 65-68. https://doi.org/10.11648/j.ijovs.20170203.11

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    ACS Style

    Caleb Roy Walker; David Alan Reichstein. Bilateral Metastases of Colorectal Cancer to the Choroid and Optic Disc. Int. J. Ophthalmol. Vis. Sci. 2017, 2(3), 65-68. doi: 10.11648/j.ijovs.20170203.11

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    AMA Style

    Caleb Roy Walker, David Alan Reichstein. Bilateral Metastases of Colorectal Cancer to the Choroid and Optic Disc. Int J Ophthalmol Vis Sci. 2017;2(3):65-68. doi: 10.11648/j.ijovs.20170203.11

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  • @article{10.11648/j.ijovs.20170203.11,
      author = {Caleb Roy Walker and David Alan Reichstein},
      title = {Bilateral Metastases of Colorectal Cancer to the Choroid and Optic Disc},
      journal = {International Journal of Ophthalmology & Visual Science},
      volume = {2},
      number = {3},
      pages = {65-68},
      doi = {10.11648/j.ijovs.20170203.11},
      url = {https://doi.org/10.11648/j.ijovs.20170203.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20170203.11},
      abstract = {Introduction: Metastatic colorectal cancer is highly fatal disease. While metastases are usually found in the thoracic cavity in colorectal cancer, the choroid has been shown to harbor metastases. The retrobuorbital pathway, although rarely, has also demonstrated colorectal metastases. Case report: A 54-year-old male with a one-year history of disseminated colon cancer presented with vision loss in his right eye in October 2013. A choroidal metastasis was found extending from the optic disc toward the fovea, Initial treatment consisted of systemic chemotherapy, supplemented by External Beam Radiation Therapy to the right eye one year after diagnosis. Thirteen months later, the left eye was found to have a choroidal tumor surrounding the disc. The cancer progressed through both local and systemic treatment. Discussion: While the disease progressed through multiple rounds of chemotherapy, external beam radiation therapy was shown to be effective in regressing the tumors. Managing refractory metastatic disease presents unique challenges in properly prioritizing therapeutic routes.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Bilateral Metastases of Colorectal Cancer to the Choroid and Optic Disc
    AU  - Caleb Roy Walker
    AU  - David Alan Reichstein
    Y1  - 2017/06/12
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    T2  - International Journal of Ophthalmology & Visual Science
    JF  - International Journal of Ophthalmology & Visual Science
    JO  - International Journal of Ophthalmology & Visual Science
    SP  - 65
    EP  - 68
    PB  - Science Publishing Group
    SN  - 2637-3858
    UR  - https://doi.org/10.11648/j.ijovs.20170203.11
    AB  - Introduction: Metastatic colorectal cancer is highly fatal disease. While metastases are usually found in the thoracic cavity in colorectal cancer, the choroid has been shown to harbor metastases. The retrobuorbital pathway, although rarely, has also demonstrated colorectal metastases. Case report: A 54-year-old male with a one-year history of disseminated colon cancer presented with vision loss in his right eye in October 2013. A choroidal metastasis was found extending from the optic disc toward the fovea, Initial treatment consisted of systemic chemotherapy, supplemented by External Beam Radiation Therapy to the right eye one year after diagnosis. Thirteen months later, the left eye was found to have a choroidal tumor surrounding the disc. The cancer progressed through both local and systemic treatment. Discussion: While the disease progressed through multiple rounds of chemotherapy, external beam radiation therapy was shown to be effective in regressing the tumors. Managing refractory metastatic disease presents unique challenges in properly prioritizing therapeutic routes.
    VL  - 2
    IS  - 3
    ER  - 

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Author Information
  • Tennessee Retina, Nashville, USA

  • Tennessee Retina, Nashville, USA

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